CAS 92309-29-0

Mistura de imipenem-cilastatina

Descrição:

Imipenem-cilastatina é um antibiótico combinado usado principalmente para o tratamento de infecções bacterianas graves. O imipenem é um antibiótico de amplo espectro da classe dos carbapenêmicos, eficaz contra uma ampla gama de bactérias Gram-positivas e Gram-negativas, incluindo muitas cepas resistentes. A cilastatina é um inibidor da dehidropeptidase renal que previne a degradação do imipenem nos rins, aumentando assim sua eficácia e reduzindo a nefrotoxicidade. A combinação é particularmente útil no tratamento de infecções causadas por organismos multirresistentes. O imipenem-cilastatina é tipicamente administrado por via intravenosa e é indicado para condições como pneumonia, infecções intra-abdominais e infecções do trato urinário. A farmacocinética dessa mistura envolve rápida distribuição nos tecidos do corpo, com uma meia-vida relativamente curta, necessitando de múltiplas doses para níveis terapêuticos sustentados. Os efeitos adversos podem incluir distúrbios gastrointestinais, reações alérgicas e, menos comumente, convulsões, particularmente em pacientes com comprometimento renal. No geral, o imipenem-cilastatina é uma opção crítica no arsenal de antibióticos, especialmente para infecções graves onde outros tratamentos podem falhar.

Fórmula: C₂₈H₄₃N₅O₉S₂

InChI: InChI=1/C16H26N2O5S.C12H17N3O4S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19)/b12-6-;/t10-,11-;6-,7-,9-/m11/s1

Chave InChI: InChIKey=NCCJWSXETVVUHK-ZYSAIPPVSA-N

SMILES: C(N/C(=C\CCCCSC[C@@H](C(O)=O)N)/C(O)=O)(=O)[C@@H]1C(C)(C)C1.C(O)(=O)C=1N2[C@@]([C@@]([C@@H](C)O)(C2=O)[H])(CC1SCCNC=N)[H]

Sinónimos:

• (2Z)-7-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid - (5R,6S)-3-[(2-{[(1E)-aminomethylidene]amino}ethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (1:1)
• (2Z)-7-{[(2S)-2-amino-2-carboxyethyl]sulfanyl}-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid - (5R,6S)-3-[(2-{[(E)-aminomethylidene]amino}ethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate (1:1:1)
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, [5R-[5α,6α(R*)]]-, mixt. with [R-[R*,S*-(Z)]]-7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid
• 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-, (5R,6S)-, mixt. with (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
• 2-Heptenoic acid, 7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-, [R-[R*,S*-(Z)]]-, mixt. contg.
• 2-Heptenoic acid, 7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-, (2Z)-, mixt. contg.
• Cilastatin-imipenem mixt.
• Imipenem-cilastatin mixt.
• Primaxin
• Primaxin IV
• Sodium (Z)-7-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate (5R,6S)-3-[2-(aminomethylideneamino)ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid hydrate
• Tainem
• Tienam 500
• 7-[(2S)-2-amino-2-carboxy-ethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopro panecarbonyl]amino]hept-2-enoic acid: (5R)-3-[2-(aminomethylideneamino )ethylsulfanyl]-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene -2-carboxylic acid
• Mk 787-mk 791 mixture
• Mk 0787-mk 0791 mixture
• IMipeneM and Cilastatin SodiuM with SodiuM Bicarbonate
• 85960-17-4 (Hydrochloride salt)
• 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, (5R-(5alpha,6alpha(R*)))-, mixt. with (R-(R*,S*-(Z)))-7-((2-amino-2-carboxyethyl)thio)-2-(((2,2-dimethylcyclopropyl)carbonyl)amino)-2-heptanoic acid
• Thienam
• Imipenem-Cilastatin sodium hydrate USP/EP/BP

Imipenem-cilastatin sodium hydrate, Antibiotic for Culture Media Use Only

CAS: 92309-29-0

Imipenem-cilastatin sodium hydrate is a fine chemical that belongs to the category of research chemicals. It is a complex compound and versatile building block with a wide range of applications in research, development, and production of pharmaceuticals. Imipenem-cilastatin sodium hydrate has been used as a reagent for the synthesis of other compounds, as well as an intermediate for various reactions or as a scaffold for drug discovery. It is also useful in the preparation of high quality speciality chemicals.

Fórmula: C₂₈H₄₄N₅NaO₁₀S₂

Pureza: 40 To 60 Area-%

Cor e Forma: White Powder

Peso molecular: 697.8 g/mol

Ref: 3D-FI148817