CAS 92921-24-9

Sulfo-SMCC sódio

Descrição:

Sulfo-SMCC sódio, com o número CAS 92921-24-9, é um composto químico comumente utilizado como agente de reticulação em bioconjugação e química de proteínas. É um reagente solúvel em água que facilita a formação de ligações covalentes estáveis entre proteínas, peptídeos e outras biomoléculas, tornando-o valioso em várias aplicações, como desenvolvimento de medicamentos, diagnósticos e a criação de conjugados de anticorpos e medicamentos. O composto apresenta um grupo sulfonato, que melhora sua solubilidade em soluções aquosas, e uma parte de maleimida que reage seletivamente com grupos tiol em resíduos de cisteína de proteínas. Essa especificidade permite modificações precisas de biomoléculas, permitindo que os pesquisadores estudem interações, estabilidade e função de proteínas. Além disso, Sulfo-SMCC sódio é caracterizado por suas condições de reação suaves, tornando-o adequado para uso com moléculas biológicas sensíveis. Devem ser observadas precauções de segurança ao manusear este reagente, assim como com qualquer químico, para minimizar a exposição e garantir práticas laboratoriais adequadas.

Fórmula: C₁₆H₁₇N₂NaO₉S

InChI: InChI=1/C16H18N2O9S.Na/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26;/h5-6,9-11H,1-4,7-8H2,(H,24,25,26);/q;+1/p-1/rC16H17N2NaO9S/c19-28-29(25,26)11-7-14(22)18(15(11)23)27-16(24)10-3-1-9(2-4-10)8-17-12(20)5-6-13(17)21/h5-6,9-11H,1-4,7-8H2

Chave InChI: InChIKey=VRMVBDHSLMDJAD-UHFFFAOYSA-N

SMILES: O(C(=O)C1CCC(CN2C(=O)C=CC2=O)CC1)N3C(=O)C(S(=O)(=O)O)CC3=O.[Na]

Sinónimos:

• 3-Pyrrolidinesulfonic acid, 1-[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]oxy]-2,5-dioxo-, sodium salt
• Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester, sodium salt (1:1)
• SMCC, Water-Soluble
• Sulfo-SMCC sodium
• Sulfo-Smcc
• Sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate
• Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt
• [1-[4-[(2,5-Dioxopyrrol-1-Yl)Methyl]Cyclohexanecarbonyl]Oxy-2,5-Dioxo-Pyrrolidin-3-Yl]Sulfonyloxysodium
• SULFO-SMCC SulfosucciniMidyl-trans-4-(n-MaleiMidoMethyl)cyclohexane-1-carboxylate
• Sulfo-N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate
• 3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt
• 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysucciniMide ester sodiuM salt, 98+%
• 4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-Cyclohexanecarboxylic acid 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester sodium salt (1:1)
• 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester
• SULFOSUCCINIMIDYL-TRANS-4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
• Sulpho SMCC sodium salt
• SULFO SUCCINIMIDYL-4-(N-MALEIMIDO METHYL) CYCLOHEXANE-1-CARBOXYLATE
• Sulfo-SMCCSulfosucciniMidyl-trans-4-(n-MaleiMidoMethyl)
• Sodium 1-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarbonyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate
• 3-Sulfo-N-succiniMidyl 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate SodiuM Salt
• 4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLIC ACID 3-SULFO-N-HYDROXYSUCCINIMIDE ESTER SODIUM SALT
• Sulfo-N-Succinimidyl-4-(malemidonethyl)cyclohexane-1-carboxylate,sodium salt
• Sulfo-SMCC SodiuM Salt
• 4-(MaleiMidoMethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysucciniMide ester sodiuM salt, 98+%
• 4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)Methyl]cyclohexanecarboxylic Acid 2,5-Dioxo-3-sulfo-1-pyrrolidinyl Ester, SodiuM Salt
• SULFO-N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE, SODIUM SALT
• Sulfo-SMCC Crosslinker
• SulfosucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate(Sulfo-SMCC)

3-Sulfo-N-succinimidyl 4-(N-Maleimidomethyl)cyclohexane-1-carboxylate Sodium Salt

CAS: 92921-24-9

Fórmula: C₁₆H₁₇N₂NaO₉S

Pureza: >97.0%(qNMR)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 436.37

Ref: 3B-S0883

3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt, 97+%

CAS: 92921-24-9

3-Sulfo-N-succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate sodium salt is a cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second co

Fórmula: C₁₆H₁₇N₂NaO₉S

Pureza: 97+%

Cor e Forma: Off-white to white, Solid

Peso molecular: 436.37

Ref: 02-H54807

Sulfo-N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate, Sodium Salt

CAS: 92921-24-9

Fórmula: C₁₆H₁₇N₂NaO₉S

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 436.3689

Ref: IN-DA006K94

Sodium 1-((4-((2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Methyl)Cyclohexanecarbonyl)Oxy)-2,5-DioxoPyrrolidine-3-Sulfonate

CAS: 92921-24-9

Sodium 1-((4-((2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-yl)Methyl)Cyclohexanecarbonyl)Oxy)-2,5-DioxoPyrrolidine-3-Sulfonate

Pureza: 95%

Peso molecular: 436.37g/mol

Ref: 54-OR1030515

Sulfo-SMCC sodium

CAS: 92921-24-9

Sulfo-SMCC sodium

Pureza: ≥98%

Peso molecular: 436.37g/mol

Ref: 54-BUP11004

Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt

CAS: 92921-24-9

Sulphosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt

Fórmula: C₁₆H₁₇N₂O₉S·Na

Pureza: 98% (Typical Value in Batch COA)

Cor e Forma: white solid

Peso molecular: 436.37g/mol

Ref: 54-BICL207

Sulfo-SMCC sodium

CAS: 92921-24-9

Sulfo-SMCC sodium: hetero-bifunctional ADC crosslinker with NHS ester and maleimide for amines and sulfhydryls.

Fórmula: C₁₆H₁₇N₂NaO₉S

Pureza: 98.07% - 99.9%

Cor e Forma: Solid

Peso molecular: 436.37

Ref: TM-T18728

Sulfo-SMCC sodium

CAS: 92921-24-9

Crosslinker reacting rapidly with primary amines.  It is used as a protein crosslinker where it reacts with cysteine to yield specific conjugates.  The cyclohexane bridge confers added stability to the maleimide group making it ideal for maleimide activation of proteins.  It is soluble in water and many other aqueous buffers although it is less stable then in DMSO or DMF.

Fórmula: C₁₆H₁₇N₂O₉SNa

Pureza: Min. 95 Area-%

Cor e Forma: White Off-White Powder

Peso molecular: 436.37 g/mol

Ref: 3D-FS27953

Sulfo-SMCC sodium

CAS: 92921-24-9

Pureza: 96%

Peso molecular: 436.3699951

Ref: 10-F869416