CAS 936563-96-1

1-((3r)-3-(4-amino-3-(4-fenoxifenil)-1h-pirazolo(3,4-d)pirimidin-1-il)-1-piperidinil)-2-propen-1-ona

Descrição:

A substância química conhecida como 1-((3r)-3-(4-amino-3-(4-fenoxifenil)-1h-pirazolo(3,4-d)pirimidin-1-il)-1-piperidinil)-2-propen-1-ona, com o número CAS 936563-96-1, é um composto orgânico complexo caracterizado por sua estrutura multifuncional. Apresenta um núcleo de pirazolo-pirimidina, conhecido por sua atividade biológica, particularmente em química medicinal. A presença de um grupo amino e um moiety de fenoxifenila sugere interações potenciais com alvos biológicos, tornando-o um candidato para aplicações farmacêuticas. O anel de piperidina contribui para sua basicidade e pode influenciar suas propriedades farmacocinéticas. Além disso, o grupo carbonila α,β-insaturado (2-propen-1-ona) é significativo para a reatividade, permitindo potencialmente modificações químicas adicionais. No geral, a estrutura intrincada deste composto indica um potencial para diversas atividades biológicas, justificando uma investigação mais aprofundada no desenvolvimento de medicamentos e aplicações terapêuticas.

Fórmula: C₂₅H₂₄N₆O₂

InChI: InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)/t18-/m1/s1

Chave InChI: InChIKey=XYFPWWZEPKGCCK-GOSISDBHSA-N

SMILES: NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(C=C)=O)CCC5)=NC=N1

Sinónimos:

• (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-propenone
• 2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-
• Cra 032765
• Ibrutinib
• Imbruvica
• Jnj 02
• Pci 32765-00
• Pci-32765
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• 1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl)pyrazolo[3, 4-d]pyriMidin-1-yl]piperidin-1-yl]prop-2-en-1-one
• PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
• PCI-32765 (Ibrutinib)
• Ibrutinib (PCI-32765)
• 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one

1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

CAS: 936563-96-1

Fórmula: C₂₅H₂₄N₆O₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 440.4971

Ref: IN-DA003620

Ibrutinib

CAS: 936563-96-1

Ibrutinib

Pureza: 98%

Peso molecular: 440.5g/mol

Ref: 54-OR1029554

Ibrutinib (PCI-32765)

CAS: 936563-96-1

Fórmula: C₂₅H₂₄N₆O₂

Cor e Forma: White To Off-White Solid

Peso molecular: 440.51

Ref: 4Z-I-061003

Ibrutinib

CAS: 936563-96-1

Ibrutinib

Pureza: ≥98%

Peso molecular: 440.5g/mol

Ref: 54-BUP15079

Ibrutinib

CAS: 936563-96-1

Fórmula: C₂₅H₂₄N₆O₂

Pureza: ≥ 98.0%

Cor e Forma: White or almost white powder

Peso molecular: 440.50

Ref: 7W-GP8742

Ibrutinib

Produto Controlado

CAS: 936563-96-1

Fórmula: C₂₅H₂₄N₆O₂

Cor e Forma: Neat

Peso molecular: 440.50

Ref: 86-MM3746.00

Ibrutinib

CAS: 936563-96-1

Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.

Fórmula: C₂₅H₂₄N₆O₂

Pureza: 98% - 99.93%

Cor e Forma: Solid

Peso molecular: 440.5

Ref: TM-T1835

Ibrutinib

Produto Controlado

CAS: 936563-96-1

Applications Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Fórmula: C₂₅H₂₄N₆O₂

Cor e Forma: Off-White

Peso molecular: 440.50

Ref: TR-I124970

Ibrutinib-d4 (Major)

Produto Controlado

CAS: 936563-96-1

Applications Ibrutinib-d4 is the labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Fórmula: C₂₅H₂₀D₄N₆O₂

Cor e Forma: Neat

Peso molecular: 444.52

Ref: TR-I124971

Ibrutinib

CAS: 936563-96-1

Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase, a crucial enzyme to the B-cell receptor pathway. Bruton’s tyrosine kinase becomes continuously activated in B-cell cancers and therefore promotes the survival of tumor cells. Ibrutinib binds irreversibly and covalently to a cysteine residue within the ATP-binding site of the enzyme, thus preventing ATP binding and downstream signal transduction. The ability of Ibrutinib to inhibit Bruton’s tyrosin kinase and hence the B-cell receptor pathway it can be used in the treatment of some B cell cancers such as diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL).

Fórmula: C₂₅H₂₄O₂N₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 440.5 g/mol

Ref: 3D-FA34130

Ibrutinib - Bio-X ™

CAS: 936563-96-1

Ibrutinib is a small-molecule inhibitor of Bruton’s tyrosine kinase, a crucial enzyme to the B-cell receptor pathway. Bruton’s tyrosine kinase becomes continuously activated in B-cell cancers and therefore promotes the survival of tumor cells. Ibrutinib binds irreversibly and covalently to a cysteine residue within the ATP-binding site of the enzyme, thus preventing ATP binding and downstream signal transduction. The ability of Ibrutinib to inhibit Bruton’s tyrosin kinase and hence the B-cell receptor pathway it can be used in the treatment of some B cell cancers such as diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL).

Fórmula: C₂₅H₂₄O₂N₆

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 440.5 g/mol

Ref: 3D-BI164531

Ibrutinib

CAS: 936563-96-1

Pureza: 99%

Peso molecular: 440.51

Ref: 10-F799864