CAS 96736-12-8

L-Leucinamida, D-arginil-L-prolil-L-lisil-L-prolil-D-fenilalanil-L-glutaminil-D-triptofanil-L-fenilalanil-D-triptofanil-L-leucil-

Descrição:

L-Leucinamida, D-arginil-L-prolil-L-lisil-L-prolil-D-fenilalanina-L-glutamina-D-triptofano-L-fenilalanina-D-triptofano-L-leucina é um peptídeo complexo composto por vários aminoácidos, incluindo tanto enantiômeros L quanto D. Esta estrutura sugere que pode exibir propriedades biológicas únicas devido à presença de ambas as formas de aminoácidos, que podem influenciar suas interações com sistemas biológicos. A presença de múltiplos resíduos de prolina pode contribuir para sua estabilidade estrutural e potencial para formar conformações específicas. A sequência do peptídeo indica um papel potencial em processos biológicos, possivelmente relacionado a funções de sinalização ou estruturais em proteínas. Seu número CAS, 96736-12-8, permite uma identificação precisa em bancos de dados químicos. No entanto, informações detalhadas sobre sua solubilidade, estabilidade e atividades biológicas específicas exigiriam estudos empíricos, uma vez que essas características podem variar significativamente com base na conformação e no ambiente do peptídeo. No geral, este composto representa uma área fascinante de estudo em química de peptídeos e bioquímica.

Fórmula: C₇₉H₁₀₉N₁₉O₁₂

Sinónimos:

• SubstanceP,1-D-arginine-5-D-phenylalanine-7-D-tryptophan-9-D-tryptophan-11-L-leucinamide-
• L 756867
• [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P
• D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-Nh2

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P

CAS: 96736-12-8

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P initially described as a low potency ghrelin receptor antagonist has surprisingly been found to be a full inverse agonist (EC₅₀ = 5.2 nM). In COS-7 cells transiently transfected with the ghrelin receptor the substance P analog rPKPfQwFwLL decreased the constitutive signaling down to levels observed in untransfected cells. Assuming that constitutive signaling of the ghrelin receptor is of physiological relevance in the regulation of appetite control, inverse agonists of the ghrelin receptor could be interesting for the treatment of obesity. So, Asakawa et al. found that peripherally administered H-6395 decreased food intake in lean mice, in mice with diet induced obesity, and in ob/ob obese mice.

Fórmula: C₇₉H₁₀₉N₁₉O₁₂

Pureza: 98.2%

Cor e Forma: White Lyophilisate

Peso molecular: 1516.86

Ref: 01-4013823

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

CAS: 96736-12-8

Broad-spectrum inverse agonist; potent at ghrelin receptor (EC50=5.2 nM); blocks other neuropeptide receptors; induces apoptosis; inhibits tumor growth.

Fórmula: C₇₉H₁₀₉N₁₉O₁₂

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 1516.85

Ref: TM-TP1931

[D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P

CAS: 96736-12-8

Fórmula: C₇₉H₁₀₉N₁₉O₁₂

Pureza: ≥ 95.0%

Cor e Forma: White powder

Peso molecular: 1516.83

Ref: 7W-GL9471

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

CAS: 96736-12-8

Substance P is a neuropeptide that belongs to the Feeding Regulatory Peptides family. It is synthesized in the hypothalamus and secreted by neurons in the spinal cord, brainstem, and gut. Substance P has been shown to regulate feeding behavior through its interaction with opioid receptors and the release of other neurotransmitters. The synthetic form of this peptide has been shown to reduce body fat in animal models and increased sensitivity to insulin in diabetic patients. This peptide also reduces camp levels in rats, which may be due to its ability to stimulate secretion of camp from pancreatic cells.

Fórmula: C₇₉H₁₀₉N₁₉O₁₂

Pureza: Min. 95%

Peso molecular: 1,516.87 g/mol

Ref: 3D-PGH-3652-PI

(D-Arg1,D-Phe5,D-Trp7·9,Leu11)-Substance P

CAS: 96736-12-8

Substance P is a neuropeptide that binds to the tachykinin receptor NK1. It has potent anti-inflammatory and mitogenic activities, which are mediated through its binding to the NK1 receptor. Substance P can stimulate lung cancer cells to proliferate and inhibit their apoptosis, which may be due to an autocrine mechanism. In addition, it has been shown that substance P can potentiate the growth of some cancers such as colon cancer in vitro and in vivo by increasing DNA synthesis and cell proliferation. This peptide also has a dose-dependent effect on cell growth, with high doses inhibiting cell proliferation at higher levels than low doses.

Fórmula: C₇₉H₁₀₉N₁₉O₁₂

Pureza: Min. 95%

Peso molecular: 1,516.83 g/mol

Ref: 3D-FA109992