CAS 96829-58-2

Tetra-hidrolipstatina

Descrição:

Tetra-hidrolipstatina, também conhecido como orlistato, é um potente inibidor de lipase usado principalmente no manejo da obesidade. Funciona inibindo a lipase pancreática, uma enzima responsável pela decomposição das gorduras dietéticas em ácidos graxos livres absorvíveis. Essa inibição leva a uma redução na absorção de gordura do trato gastrointestinal, promovendo a perda de peso. Tetra-hidrolipstatina é um pó branco a off-white que é praticamente insolúvel em água, mas solúvel em solventes orgânicos. Sua estrutura molecular inclui um anel de lactona e uma longa cadeia de ácidos graxos, contribuindo para sua natureza lipofílica. O composto é tipicamente administrado em forma de cápsula e é frequentemente usado em conjunto com uma dieta de calorias reduzidas e exercícios para um gerenciamento eficaz do peso. Os efeitos colaterais podem incluir desconforto gastrointestinal, como fezes oleosas e flatulência, devido às gorduras não absorvidas. No geral, Tetra-hidrolipstatina representa uma abordagem única para a perda de peso, visando a absorção de gordura em vez da supressão do apetite.

Fórmula: C₂₉H₅₃NO₅

InChI: InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1

Chave InChI: InChIKey=AHLBNYSZXLDEJQ-FWEHEUNISA-N

SMILES: C([C@@H](OC([C@H](CC(C)C)NC=O)=O)CCCCCCCCCCC)[C@H]1[C@H](CCCCCC)C(=O)O1

Sinónimos:

• (-)-Tetrahydrolipstatin
• (1S)-1-{[(2R,3S)-3-hexyl-4-oxooxetan-2-yl]methyl}dodecyl N-formyl-D-leucinate
• (S)-2-Formylamino-4-Methyl-Pentanoic Acid (S)-1-[[(2S,3S)-3-Hexyl-4-Oxo-2-Oxetanyl]Methyl]-Dodecyl Ester
• <span class="text-smallcaps">L</span>-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
• <span class="text-smallcaps">L</span>-Leucine, N-formyl-, 1-[(3-hexyl-4-oxo-2-oxetanyl)methyl]dodecyl ester, [2S-[2α(R*),3β]]-
• Listata
• N-Formyl-L-Leucine (1S)-1-[[(2S,3S)-3-Hexyl-4-Oxo-2-Oxetanyl]Methyl]Dodecyl Ester
• Orlipastat
• Ro 18-0647/002
• Ro-18-0647
• Xenical
• [(1S)-1-[[(2S)-3-hexyl-4-oxo-oxetan-2-yl]methyl]dodecyl] (2S)-2-formamido-4-methyl-pentanoate
• L-Leucine, N-formyl-, 1-[(3-hexyl-4-oxo-2-oxetanyl)methyl]dodecyl ester, [2S-[2α(R*),3β]]-

Orlistat

CAS: 96829-58-2

Fórmula: C₂₉H₅₃NO₅

Pureza: >97.0%(HPLC)(N)

Cor e Forma: White to Almost white powder to crystal

Peso molecular: 495.75

Ref: 3B-O0381

Orlistat, 98%

CAS: 96829-58-2

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL

Fórmula: C₂₉H₅₃NO₅

Pureza: 98%

Peso molecular: 495.73

Ref: 02-J62999

Orlistat

CAS: 96829-58-2

Lactones, nesoi

Fórmula: C₂₉H₅₃NO₅

Cor e Forma: White Powder

Peso molecular: 495.39237

Ref: 45-1478800

Orlistat

CAS: 96829-58-2

Orlistat (Tetrahydrolipstatin) is a lipase inhibitor and a FASN inhibitor. Orlistat has been shown to promote weight loss. Cost effective and quality assured.

Fórmula: C₂₉H₅₃NO₅

Pureza: 99.58% - >99.99%

Cor e Forma: White Crystalline Powder

Peso molecular: 495.73

Ref: TM-T0686

(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate

CAS: 96829-58-2

Fórmula: C₂₉H₅₃NO₅

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 495.7348

Ref: IN-DA0035FN

Orlistat Powder

CAS: 96829-58-2

Orlistat Powder

Pureza: 98%

Peso molecular: 495.73g/mol

Ref: 54-OR1029653

Orlistat

CAS: 96829-58-2

Orlistat

Pureza: ≥98%

Peso molecular: 495.73g/mol

Ref: 54-BUP17083

Orlistat

CAS: 96829-58-2

Fórmula: C₂₉H₅₃NO₅

Pureza: ≥ 97.0%

Cor e Forma: White to almost white powder or solid

Peso molecular: 495.73

Ref: 7W-GP9255

Orlistat

CAS: 96829-58-2

Fórmula: C₂₉H₅₃NO₅

Cor e Forma: White To Off-White Solid

Peso molecular: 495.75

Ref: 4Z-O-183

Orlistat

CAS: 96829-58-2

Fórmula: C₂₉H₅₃NO₅

Cor e Forma: Neat

Peso molecular: 495.73

Ref: 04-C15744000

Orlistat

CAS: 96829-58-2

Fórmula: C₂₉H₅₃NO₅

Cor e Forma: Neat

Peso molecular: 495.73

Ref: 86-MM1219.00

Orlistat-d7

CAS: 96829-58-2

Fórmula: C₂₉H₄₆D₇NO₅

Peso molecular: 502.79

Ref: 4Z-O-01827

Orlistat

Produto Controlado

CAS: 96829-58-2

Applications Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.
References Borgstrom, B., et al.: Biochim. Biophys. Acta, 962, 308 (1988), Hauptman, J.B., et al.: Am. J. Clin. Nutr., 55, 309S (1992), McNeely, W., et al.: Drugs, 56, 241 (1998), Hauptman, J. B., et al.: Arch. Fam. Med., 9, 160 (2000),

Fórmula: C₂₉H₅₃NO₅

Cor e Forma: White To Off-White

Peso molecular: 495.73

Ref: TR-O686500

Orlistat - Bio-X ™

CAS: 96829-58-2

Orlistat is a drug that has been approved for the treatment of obesity. It inhibits gastric and pancreatic lipases, which are enzymes that break down dietary fats into smaller molecules to facilitate absorption. Orlistat has been shown to reduce coronary heart disease in patients with type 2 diabetes. Orlistat has also been shown to have a significant upregulation of gene expression associated with disease activity when injected into the skin of patients with primary pulmonary hypertension.
Orlistat is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™  products are in stock across our global warehouses for rapid delivery and ease of use.

Fórmula: C₂₉H₅₃NO₅

Cor e Forma: Powder

Peso molecular: 495.73 g/mol

Ref: 3D-BO164179

Orlistat

CAS: 96829-58-2

Lipase inhibitor; semisynthetic derivative of lipstatin

Fórmula: C₂₉H₅₃NO₅

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 495.74 g/mol

Ref: 3D-FO26582

Orlistat

CAS: 96829-58-2

Cor e Forma: Neat

Ref: 61-FOR1219.00