CAS 979-92-0

L-Homocisteína, S-(5'-desoxiadenosina-5'-il)-

Descrição:

L-Homocisteína, S-(5'-desoxiadenosina-5'-il)-, também conhecido pelo seu número CAS 979-92-0, é um derivado de aminoácido que contém enxofre e desempenha um papel significativo em vários processos bioquímicos, particularmente no metabolismo da homocisteína. Este composto é caracterizado pela presença de uma estrutura de homocisteína ligada a um grupo de 5'-deoxiadenosina, que é crucial para sua atividade biológica. Normalmente, está envolvido em reações de metilação e é um intermediário chave na via de transulfuração, influenciando a síntese de cisteína e outras biomoléculas importantes. O composto é solúvel em água e exibe características polares devido à presença de grupos funcionais amino e carboxila. Sua importância biológica é sublinhada por sua participação na saúde cardiovascular, uma vez que níveis elevados de homocisteína estão associados a um maior risco de doenças cardiovasculares. Além disso, os derivados de L-homocisteína são estudados por seus papéis potenciais na sinalização celular e como biomarcadores para várias condições de saúde.

Fórmula: C₁₄H₂₀N₆O₅S

InChI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1

Chave InChI: InChIKey=ZJUKTBDSGOFHSH-WFMPWKQPSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CSCC[C@@H](C(O)=O)N)[C@H]1O

Sinónimos:

• (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosin
• (S)-5'-(S)-(3-amino-3-carboxipropil)-5'-tioadenosina
• (S)-5'-(S)-(3-amino-3-carboxypropyl)-5'-thioadenosine
• <span class="text-smallcaps">L</span>-Homocysteine, S-(5′-deoxyadenosin-5′-yl)-
• <span class="text-smallcaps">L</span>-S-Adenosylhomocysteine
• Adenosine, 5'-S-(3-amino-3-carboxypropyl)-5'-thio-, L-
• Adenosine, 5′-S-(3-amino-3-carboxypropyl)-5′-thio-, <span class="text-smallcaps">L</span>-
• Adenosyl-<span class="text-smallcaps">L</span>-homocysteine
• Adenosyl-L-homocysteine
• Adenosylhomocysteine
• Homocysteine, S-adenosyl-, <span class="text-smallcaps">L</span>-
• Homocysteine, S-adenosyl-, L-
• L-S-Adenosylhomocysteine
• S-(5'-Adenosyl)-L-homocysteine
• S-(5′-Adenosyl)-<span class="text-smallcaps">L</span>-homocysteine
• S-(5′-Deoxyadenosin-5′-yl)-<span class="text-smallcaps">L</span>-homocysteine
• S-Adenosyl-<span class="text-smallcaps">L</span>-homocysteine
• S-Adenosyl-L-homocysteine
• S-Adenosylhomocysteine
• SAH (S-Adenosylhomocysteine)
• L-Homocysteine, S-(5′-deoxyadenosin-5′-yl)-
• S-(5′-Deoxyadenosin-5′-yl)-L-homocysteine
• (2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid (non-preferred name)
• 2-amino-4-({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}sulfanyl)butanoic acid (non-preferred name)
• L-Homocysteine, S-(5'-deoxyadenosin-5'-yl)-
• 5'-Deoxy-s-adenosyl-L-homocysteine
• S-Adenosyl-L-homocystein
• AdenosylhoMocysteine-13C5
• S-(5'-Deoxyadenosin-5'-yl)-L-hoMocysteine-13C5
• 5μ-Deoxy-S-adenosyl-L-homocysteine, AdoHcy, S-(5μ-Deoxyadenosine-5μ)-L-homocysteine
• Adenosyl-L-hoMocysteine-13C5
• S-(5′
• (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid
• S-Adenosyl-L-Homocysteine (50 mg)
• L-5'-S-(3-AMino-3-carboxypropyl)-
• (2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methylsulfanyl]butanoic acid
• ADOHCY
• S-(5'-DEOXYADENOSINE-5')-L-HOMOCYSTEINE
• L
• S-(5'-deoxyadenosin-5'-yl)
• -homocysteine
• 5'-thioadenosine-13C5
• L-S-AdenosylhoMocysteine-13C5
• -Adenosyl)-
• hpce
• S-(5′-Adenosyl)-L-homocysteine,5′-Deoxy-S-adenosyl-L-homocysteine, AdoHcy, S-(5′-Deoxyadenosine-5′)-L-homocysteine
• S-ADENOSYL-L-HOMOCYSTEINE (ADENOSINE-13C10, 98%)
• ( 35 ) -5-( 3-AMINO.-3 CARBOXYPROPYL) THIO ) -5-DEOXYADENOSINE
• 5'-DEOXY-S-ADENOSYL-
• S-(5'-Deoxyadenosine)-L-homocysteine
• S-(5'-Adenosyl)-L-homocysteine dihydrate
• S-(5'-Adenosyl)-L-homocysteine;AdoHcy;S-(5'-Deoxyadenosine)-L-homocysteine
• 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE USP/EP/BP
• HOMOCYSTEINE, S-ADENOSYL
• 5'-thioadenosine
• Ademetionine 1,4-Butanedisulfonate Impurity 1

S-Adenosyl-L-Homocysteine

CAS: 979-92-0

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₄H₂₀N₆O₅S

Cor e Forma: White Crystalline Powder

Peso molecular: 384.12159

Ref: 45-1012112

S-Adenosyl-L-homocysteine

CAS: 979-92-0

Fórmula: C₁₄H₂₀N₆O₅S

Pureza: 97%

Cor e Forma: Solid

Peso molecular: 384.4108

Ref: IN-DA006AE7

S-Adenosyl-L-Homocysteine

CAS: 979-92-0

Fórmula: C₁₄H₂₀N₆O₅S

Peso molecular: 384.41

Ref: 4Z-C-7727

S-Adenosylhomocysteine

CAS: 979-92-0

S-Adenosylhomocysteine

Pureza: 98%

Peso molecular: 384.41g/mol

Ref: 54-OR1014905

S-(5''-Adenosyl)-L-homocysteine

CAS: 979-92-0

Fórmula: C₁₄H₂₀N₆O₅S

Pureza: (HPLC) ≥ 98.0%

Cor e Forma: White to almost white powder

Peso molecular: 384.41

Ref: 7W-GN9993

SAH

CAS: 979-92-0

SAH

Pureza: ≥98%

Peso molecular: 384.41g/mol

Ref: 54-BUP06704

SAH

CAS: 979-92-0

SAH (SAH (S-Adenosylhomocysteine)) is an inhibitor for the METTL3-METTL14 heterodimer complex (METTL3-14, IC50: 0.9 μM).

Fórmula: C₁₄H₂₀N₆O₅S

Pureza: 98.45% - >99.99%

Cor e Forma: Solid

Peso molecular: 384.41

Ref: TM-TQ0208

S-Adenosyl-L-Homocysteine-15N4

CAS: 979-92-0

Fórmula: C₁₄H₂₀N₂₁₅N₄O₅S

Peso molecular: 388.38

Ref: 4Z-C-7728

S-(5'-Adenosyl)-L-homocysteine-d4

Produto Controlado

CAS: 979-92-0

Applications S-(5'-Adenosyl)-L-homocysteine-d4 is labelled S-(5'-Adenosyl)-L-homocysteine (A291500), a novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder.
References Chamberlin, M., et al.: J. Clin. Invest., 98, 1021 (1996); Zoccolella, S., et al.: Neurology, 70, 222 (2008)

Fórmula: C₁₄D₄H₁₆N₆O₅S

Cor e Forma: Neat

Peso molecular: 388.44

Ref: TR-A291501

S-Adenosyl-L-Homocysteine

CAS: 979-92-0

Fórmula: C₁₄H₂₀N₆O₅S

Peso molecular: 384.41

Ref: ST-EA-CP-A88015

S-(5'-Adenosyl)-L-homocysteine dihydrate

CAS: 979-92-0

S-(5'-Adenosyl)-L-homocysteine dihydrate is the active form of homocysteine. It has been shown to inhibit the growth of HL-60 cells and induce apoptosis in these cells. S-(5'-Adenosyl)-L-homocysteine dihydrate binds to dsDNA as a methyltransferase inhibitor, which leads to DNA methylation and inhibits DNA binding. The inhibition of DNA binding prevents transcription, leading to cell death. This drug has also been shown to have an anti-atherosclerotic effect in a model system by inhibiting the adenosine receptor.

Fórmula: C₁₄H₂₀N₆O₅S•(H₂O)₂

Pureza: Min. 98 Area-%

Cor e Forma: Powder

Peso molecular: 420.44 g/mol

Ref: 3D-NA17223

S-(5′-deoxyadenosin-5′-yl)-L-Homocysteine

CAS: 979-92-0

Fórmula: C₁₄H₂₀N₆O₅S

Pureza: 97%

Peso molecular: 384.41

Ref: 10-F448169

S-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl-2,3,4,5-13C4)methyl-13C)-L-homocysteine

CAS: 979-92-0

Fórmula: C₉₁₃C₅H₂₀N₆O₅S

Cor e Forma: Neat

Peso molecular: 389.37

Ref: TR-A291502

S-(5-Adenosyl)-L-Homocysteine extrapure, 99%

CAS: 979-92-0

Fórmula: C₁₄H₂₀N₆O₅S

Pureza: min.99%

Cor e Forma: White, Crystalline powder

Peso molecular: 384.41

Ref: SR-46600

S-(5'-Adenosyl)-L-homocysteine

CAS: 979-92-0

Fórmula: C₁₄H₂₀N₆O₅S

Cor e Forma: Neat

Peso molecular: 384.41

Ref: TR-A291500

S-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl-13C5)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-L-homocysteine

Produto Controlado

CAS: 979-92-0

Fórmula: C₉₁₃C₅H₂₀N₆O₅S

Cor e Forma: Neat

Peso molecular: 389.37

Ref: TR-A291504

S-(((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl-13C)-L-homocysteine-13C4

Produto Controlado

CAS: 979-92-0

Fórmula: C₉₁₃C₅H₂₀N₆O₅S

Cor e Forma: Neat

Peso molecular: 389.37

Ref: TR-A291507