CAS 983-85-7

Penamecilina

Descrição:

Penamecilina é um antibiótico semissintético pertencente à classe das penicilinas, utilizado principalmente por suas propriedades antibacterianas. É caracterizado por sua capacidade de inibir a síntese da parede celular bacteriana, que é um mecanismo crucial para combater infecções bacterianas. Penamecilina é eficaz contra uma variedade de bactérias Gram-positivas e alguns organismos Gram-negativos, tornando-o valioso no tratamento de várias infecções. O composto apresenta um anel beta-lactâmico, um motivo estrutural comum nas penicilinas, que é essencial para sua atividade antimicrobiana. Sua estrutura química inclui um anel de tiazolidina e uma cadeia lateral que contribui para seu espectro de atividade e propriedades farmacocinéticas. Penamecilina é tipicamente administrado por injeção, pois não é bem absorvido quando tomado por via oral. Assim como outros antibióticos, é importante usar Penamecilina de forma judiciosa para prevenir o desenvolvimento de resistência a antibióticos. Efeitos colaterais potenciais podem incluir reações alérgicas, distúrbios gastrointestinais e interações com outros medicamentos. No geral, Penamecilina representa uma ferramenta importante no arsenal contra infecções bacterianas.

Fórmula: C₁₉H₂₂N₂O₆S

InChI: InChI=1S/C19H22N2O6S/c1-11(22)26-10-27-18(25)15-19(2,3)28-17-14(16(24)21(15)17)20-13(23)9-12-7-5-4-6-8-12/h4-8,14-15,17H,9-10H2,1-3H3,(H,20,23)/t14-,15+,17-/m1/s1

Chave InChI: InChIKey=NLOOMWLTUVBWAW-HLLBOEOZSA-N

SMILES: C(OCOC(C)=O)(=O)[C@@H]1N2[C@@]([C@H](NC(CC3=CC=CC=C3)=O)C2=O)(SC1(C)C)[H]

Sinónimos:

• (Acetyloxy)Methyl 3,3-Dimethyl-7-Oxo-6-[(Phenylacetyl)Amino]-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate
• (acetyloxy)methyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-(2S-(2alpha,5alpha,6beta))-, (acetyloxy)methyl ester
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, hydroxymethyl ester acetate (ester)
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, (acetyloxy)methyl ester
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, (acetyloxy)methyl ester
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2α,5α,6β)]-, (acetyloxy)methyl ester
• Acetoxymethyl benzylpenicillanate
• Acetoxymethyl benzylpenicillinate
• Benzylpenicillin acetoxymethyl ester
• Havapen
• Hydroxymethyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate, acetate (ester)
• Methanediol, acetate 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• Penamecilina
• Penamecilina [INN-Spanish]
• Penamecillin [USAN:INN:BAN]
• Penamecillina
• Penamecillina [DCIT]
• Penamecilline
• Penamecilline [INN-French]
• Penamecillinum
• Penamecillinum [INN-Latin]
• Penicillin G hydromethyl ester acetate
• Penicillin G, hydroxymethyl ester, acetate
• Wy 20,788

Penamecillin

Produto Controlado

CAS: 983-85-7

Applications Penamecillin is an ambulatory antibiotic used in the treatment of community-acquired pneumonia in adults. An antimicrobial agent also used in pharmacokinetics.
References Matuz, M., et al.: Basic Clin. Pharmacol. Toxicol., 117, 330 (2015), Chen, Z., et al.: Zhongguo Yiyuan Yaoxue Zazhi, 27, 220 (2007), Kovacs, I., et al.: Acta Pharmaceutica , 48, 54 (1978), Modr, Z., et al.: Farmakoterapeuticke Zpravy, 25, 199 (1979)

Fórmula: C₁₉H₂₂N₂O₆S

Cor e Forma: Neat

Peso molecular: 406.453

Ref: TR-P220230

Penamecillin

CAS: 983-85-7

Penamecillin is a broad-spectrum antibiotic, classified as a penicillin derivative. It is a biosynthetic product originating from the modification of naturally occurring penicillin, designed to enhance activity and bioavailability. The mode of action of Penamecillin involves the inhibition of bacterial cell wall synthesis. It effectively targets the penicillin-binding proteins (PBPs) within bacteria, leading to the interruption of peptidoglycan cross-linking, which is essential for bacterial cell wall structural integrity. This ultimately results in the bactericidal effect against susceptible bacterial strains.

Fórmula: C₁₉H₂₂N₂O₆S

Pureza: Min. 95%

Peso molecular: 406.5 g/mol

Ref: 3D-AAA98385

Penamecillin

CAS: 983-85-7

Penamecillin (Wy 20788) is an orally active antibacterial agent.

Fórmula: C₁₉H₂₂N₂O₆S

Cor e Forma: Solid

Peso molecular: 406.45

Ref: TM-T62023