CAS 98603-84-0

Sialil-Lewis X

Descrição:

Sialil-Lewis X, também conhecido como Lewis X sialilado, é uma estrutura de carboidrato que desempenha um papel significativo nos processos de adesão e reconhecimento celular, particularmente no contexto das respostas imunes e da metástase do câncer. É um glicano, especificamente um oligosacarídeo fucosilado sialilado, o que significa que contém resíduos de ácido siálico e fucose. Este composto é frequentemente encontrado na superfície de glicoproteínas e glicolípidos, contribuindo para a formação de ligantes de selectina que mediam o tráfego de leucócitos e a inflamação. A presença de ácido siálico confere uma carga negativa, influenciando suas interações com proteínas e outras biomoléculas. Sialil-Lewis X também é de interesse na pesquisa biomédica e aplicações terapêuticas, pois pode estar envolvido na modulação das respostas imunes e tem implicações potenciais em sistemas de entrega de medicamentos direcionados. Sua complexidade estrutural e importância biológica fazem dele um tema de estudo na glicobiologia e campos relacionados.

Fórmula: C₃₁H₅₂N₂O₂₃

InChI: InChI=1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1

Chave InChI: InChIKey=LAQPKDLYOBZWBT-NYLDSJSYSA-N

SMILES: O([C@@]1(C(O)=O)O[C@@]([C@@H]([C@@H](CO)O)O)([C@H](NC(C)=O)[C@@H](O)C1)[H])[C@@H]2[C@@H](O)[C@H](O[C@@H]([C@H](O[C@H]3[C@@H](O)[C@H](O)[C@H](O)[C@H](C)O3)[C@@H](NC(C)=O)C=O)[C@@H](CO)O)O[C@H](CO)[C@@H]2O

Sinónimos:

• 3′-Sialyl-Lewis X
• 5-(acetylamino)-3,5-dideoxy-D-erythro-non-2-ulopyranonosyl-(2->3)hexopyranosyl-(1->4)-[6-deoxyhexopyranosyl-(1->3)]-2-(acetylamino)-2-deoxyhexopyranose
• 5-(acetylamino)-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-[6-deoxy-alpha-L-galactopyranosyl-(1->3)]-2-(acetylamino)-2-deoxy-D-glucose
• <span class="text-smallcaps">D</smallcap>-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→4)-O-[6-deoxy-α-<smallcap>L</span>-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-
• O-(N-Acetyl-α-neuraminosyl)-(2→3)-O-β-<span class="text-smallcaps">D</smallcap>-galactopyranosyl-(1→4)-O-[6-deoxy-α-<smallcap>L</smallcap>-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-<smallcap>D</span>-glucose
• SLe^x
• Sialyl Le^x tri
• Sialyl Lewis X
• Ssea 1
• SLex
• D-Glucose, O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-O-[6-deoxy-α-L-galactopyranosyl-(1→3)]-2-(acetylamino)-2-deoxy-

Sialyl-Lewis X

CAS: 98603-84-0

Fórmula: C₃₁H₅₂N₂O₂₃

Pureza: 98%

Cor e Forma: Solid

Peso molecular: 820.7442

Ref: IN-DA01E70Y

Sialyl-Lewis X

CAS: 98603-84-0

sLeX: sialylated, fucosylated tetrasaccharide, ligand for selectins, inhibits neutrophil recruitment.

Fórmula: C₃₁H₅₂N₂O₂₃

Cor e Forma: Solid

Peso molecular: 820.748

Ref: TM-T35884

(2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3R,4R,5R)-5-acetamido-1,2-dihydroxy-6-oxo-4-(((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexan-3-yl)oxy)-3,5-dihydrox

CAS: 98603-84-0

(2S,4S,5R,6R)-5-Acetamido-2-(((2S,3R,4S,5S,6R)-2-(((2R,3R,4R,5R)-5-acetamido-1,2-dihydroxy-6-oxo-4-(((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)hexan-3-yl)oxy)-3,5-dihydrox

Pureza: 98%

Peso molecular: 820.75g/mol

Ref: 54-OR1067114

3′-Sialyl-Lewis-X tetrasaccharide

CAS: 98603-84-0

Fórmula: C₃₁H₅₁N₂NaO₂₃

Pureza: ≥ 85%

Cor e Forma: White to pale brown solid

Peso molecular: 842.73

Ref: 7W-GC9537

3'-Sialyl Lewis X, sodium salt

CAS: 98603-84-0

Sialyl Lewis X (SLeX) is a carbohydrate antigen, related to cell adhesion and it has been shown that inhibition of SLeX synthesis leads to decreased adhesion of trophoblast cells to endometrial epithelial cells (Collins, 2006). Sialyl Lewis X is displayed on the terminus of glycolipids that are present on the surface of white blood cells and it has been shown that SLeX has an important role in inflamation processes. The inital adhesion of white blood cells to a site of injury is mediated by E-selectins which are specific for SLeX. Cell-cell recognition between leukocytes and endothelial cells in blood is believed to occur in part through interactions between lectins and oligosaccharide ligands. SLeX is frequently expressed in human cancer cells and primary tumors. It has been demonstrated that SLeX was involved in the adhesion of tumor cells to vascular endothelium. The potential role of SLeX in the tumor metastatic process has been supported by several clinical studies (Liang, 2016).

Fórmula: C₃₁H₅₁N₂NaO₂₃

Pureza: Min. 95%

Cor e Forma: White Powder

Peso molecular: 842.73 g/mol

Ref: 3D-OS04058

3'-Sialyl Lewis X

CAS: 98603-84-0

Please enquire for more information about 3'-Sialyl Lewis X including the price, delivery time and more detailed product information at the technical inquiry form on this page

Fórmula: C₃₁H₅₂N₂O₂₃

Pureza: Min. 95%

Cor e Forma: Powder

Peso molecular: 820.75 g/mol

Ref: 3D-OS183415

Sialyl Lewis X

Produto Controlado

CAS: 98603-84-0

Applications Antigen which binds to endothelial adhesion molecule, E-selectin.
References Fukushima, K., et al.: Cancer Research, 44, 5279 (1984), Zein, N., et al.: Science, 240, 1198 (1988), Phillips, M.L., et al.: Science, 250, 1130 (1990), Walz, G., et al.: P.N.A.S. U.S.A., 88, 6224 (1991), Walker, S., et al.: P.N.A.S. U.S.A., 89, 4608 (1992)

Fórmula: C₃₁H₅₂N₂O₂₃

Cor e Forma: Off White Solid

Peso molecular: 820.74

Ref: TR-S410000