CAS 988-75-0

N-[(Fenilmetoxi)carbonil]-L-α-glutamil-L-tirosina

Descrição:

N-[(Fenilmetoxi)carbonil]-L-α-glutamil-L-tirosina, com o número CAS 988-75-0, é um composto sintético que pertence à classe de derivados de aminoácidos. Esta substância apresenta um grupo fenilmetoxicarbonila ligado à porção de ácido glutâmico, que está ainda ligado ao aminoácido tirosina. A presença do grupo fenilmetoxi aumenta sua lipofilicidade, potencialmente influenciando sua atividade biológica e solubilidade em solventes orgânicos. O composto é caracterizado por sua estrutura semelhante a um peptídeo, que pode exibir interações específicas com alvos biológicos, tornando-o de interesse na química medicinal e no design de fármacos. Sua estrutura molecular sugere aplicações potenciais em produtos farmacêuticos, particularmente no desenvolvimento de pró-fármacos ou compostos com melhor biodisponibilidade. Além disso, a presença de funcionalidades ácidas (do ácido glutâmico) e aromáticas (da tirosina) pode contribuir para sua reatividade e interação com vários sistemas biológicos. Assim como muitos derivados de aminoácidos, também pode exibir propriedades estereoespecíficas que podem afetar sua função biológica.

Fórmula: C₂₂H₂₄N₂O₈

InChI: InChI=1S/C22H24N2O8/c25-16-8-6-14(7-9-16)12-18(21(29)30)23-20(28)17(10-11-19(26)27)24-22(31)32-13-15-4-2-1-3-5-15/h1-9,17-18,25H,10-13H2,(H,23,28)(H,24,31)(H,26,27)(H,29,30)/t17-,18-/m0/s1

Chave InChI: InChIKey=XLUMOZQZGPJGTL-ROUUACIJSA-N

SMILES: C([C@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)CCC(O)=O)=O)C(O)=O)C2=CC=C(O)C=C2

Sinónimos:

• <span class="text-smallcaps">L</smallcap>-Tyrosine, N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-α-glutamyl-
• <span class="text-smallcaps">L</smallcap>-Tyrosine, N-[N-[(phenylmethoxy)carbonyl]-<smallcap>L</span>-α-glutamyl]-
• Benzyloxycarbonyl-<span class="text-smallcaps">L</smallcap>-glutamyl-<smallcap>L</span>-tyrosine
• N-Benzyloxycarbonyl-<span class="text-smallcaps">L</smallcap>-glutamyl-<smallcap>L</span>-tyrosine
• N-Carbobenzoxy-<span class="text-smallcaps">L</smallcap>-glutamyl-<smallcap>L</span>-tyrosine
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</smallcap>-α-glutamyl-<smallcap>L</span>-tyrosine
• NSC 89651
• Tyrosine, N-(N-carboxy-<span class="text-smallcaps">L</smallcap>-α-glutamyl)-, N-benzyl ester, <smallcap>L</span>-
• Z-Glu-Tyr-Oh
• Tyrosine, N-(N-carboxy-L-α-glutamyl)-, N-benzyl ester, L-
• N-[(Phenylmethoxy)carbonyl]-L-α-glutamyl-L-tyrosine
• n-Carbobenzoxy-L-glutamyl-L-tyrosine
• L-Tyrosine, N-[(phenylmethoxy)carbonyl]-L-α-glutamyl-

Z-Glu-Tyr-OH

CAS: 988-75-0

Substrate for porcine cathepsin A and acid carboxypeptidases from A. niger.and A. kawachii.

Fórmula: C₂₂H₂₄N₂O₈

Pureza: > 99%

Cor e Forma: White Powder

Peso molecular: 444.44

Ref: 01-4001669

Z-Glu-Tyr-OH

CAS: 988-75-0

Z-Glu-Tyr-OH

Ref: 54-OR1076717

Z-Glu-Tyr

CAS: 988-75-0

Z-Glu-Tyr is a synthetic substrate of the enzyme cathepsin B. The amino acid sequence of Z-Glu-Tyr has been shown to be identical to the sequence of the natural substrate, L-glutaminyl-L-tyrosine. The activity of the enzyme cathepsin B can be inhibited by Z-Glu-Tyr due to its ability to form a covalent bond with cysteine residues in the active site. This inhibition prevents cleavage of peptide bonds and synthesis of polypeptides, which are necessary for cell growth and division. Z-Glu-Tyr is also an inhibitor of thiol proteases, such as papain and subtilisin, which are enzymes that hydrolyze peptide bonds in proteins.

Fórmula: C₂₂H₂₄N₂O₈

Pureza: Min. 95%

Peso molecular: 444.43 g/mol

Ref: 3D-SEY-3018

Z-Glu-Tyr-OH

CAS: 988-75-0

Z-Glu-Tyr-OH is a disulfide bond with a cavity. It is soluble in acidic solutions and has a cationic surface. Z-Glu-Tyr-OH is an enzyme inhibitor that blocks the activity of α subunit of protein kinase C, which is involved in intracellular signal transduction pathways. The inhibition of this enzyme may lead to apoptosis, or programmed cell death. Z-Glu-Tyr-OH also inhibits fatty acid synthesis by blocking the activity of hydroxylase enzymes, such as 3β-hydroxysteroid dehydrogenase and 17α-hydroxylase. This compound has been shown to inhibit indole-3-propionic acid production by inhibiting the kinetic and sephadex g-100 activities of the enzyme indoleamine 2,3 dioxygenase.

Fórmula: C₂₂H₂₄N₂O₈

Pureza: Min. 95%

Peso molecular: 444.43 g/mol

Ref: 3D-FG110840