Derivados de Aminoácidos

Fmoc-NH-PEG6-alcohol, a cleavable ADC linker, is employed in the synthesis of antibody-drug conjugates (ADCs) [1].

(R)-2-formamido-4-methylpentanoic acid is a derivative of leucine.

L-Phenylalanyl-L-threonine is a dipeptide composed of phenylalanine and threonine, which can be utilized in the synthesis of the cyclic hexapeptide [Banyascyclamide A].

Erizepine, an octopamine receptor 3 (OAR3) antagonist, exhibits a Ki value of 474 nM. This compound is utilized in insect research.

D-allo-Threoninol is a conformational analogue of threonine. It has been shown to inhibit the growth of Escherichia coli, Bacillus subtilis, and Staphylococcus aureus in vitro. D-allo-Threoninol binds to the enzyme methionine adenosyltransferase (MAT) by forming hydrogen bonds with its amino acid side chains. This binding prevents the formation of the MAT-coenzyme A complex, inhibiting protein synthesis and cell division.

<p>The peptide RVL-psi[CH2NH]FEA-Nle-amide containing a reduced peptide bond was found to be a competitive inhibitor of the HIV-1 protease (Ki = 50 nM).</p>

<p>Bachem ID: 4012218.</p>

<p>Cyclolinopeptide B has been isolated from the seeds of Linum usitatissimum. It showed potent immunosuppressive activity comparable with that of cyclosporin A.</p>

<p>Bachem ID: 4030725.</p>

<p>Bachem ID: 4041119.</p>

<p>Bachem ID: 4097932.</p>

<p>This 25 residue peptide was completely resistant to proteolysis by cathepsin B even after incubation overnight. It inhibited human cathepsin B with Ki = 2.8 µM and rat cathepsin B with Ki = 2 µM.</p>

<p>Main degradation product of NPY in serum and Y2/Y5 receptor agonist.</p>

<p>Bachem ID: 4099858.</p>

<p>Bachem ID: 4007396.</p>

<p>The lipopeptide FSL-1, synthesized on the basis of the N-terminal structure of a M. salivarium lipoprotein, is capable of inducing the cell surface expression of ICAM-1 in human gingival fibroblasts. It furthermore revealed an activity to induce production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. FSL-1 also activated macrophages to produce tumor necrosis factor alpha. Overall, results by Okusawa and coworkers suggest that the diacylglyceryl and the peptide portions of FSL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6. Furthermore, the same authors conclude that the recognition of FSL-1 by Toll-like receptors 2 and 6 apparently is hydrophobic.</p>

<p>Bachem ID: 4097460.</p>

<p>The TNF-α antagonist WP9QY inhibited TNF-α mediated apoptosis and exhibited an IC₅₀ of 5 µM in the binding assay. YCWSQYLCY is the smallest peptidomimetic developed to date that might be used as a lead compound for the next generation of non-peptidic inhibitors. The name WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor(I) complex designated WP9 and the introduction of the amino acids Gln and Tyr.</p>

<p>Phe-CMK, inhibitor of gramicidin S synthetase 2.</p>