Bcr-Abl
Os inibidores de Bcr-Abl são terapias direcionadas que inibem a proteína de fusão Bcr-Abl, que é formada devido à translocação do cromossomo Filadélfia e é um dos principais fatores da leucemia mieloide crônica (LMC). Essa proteína também influencia a angiogênese, contribuindo para a progressão do tumor. Os inibidores de Bcr-Abl são essenciais no tratamento da LMC e estão sendo explorados por seu potencial em inibir a angiogênese em vários tipos de câncer. Na CymitQuimica, oferecemos inibidores de Bcr-Abl de alta qualidade para apoiar sua pesquisa em biologia do câncer, angiogênese e terapias direcionadas.
Foram encontrados 119 produtos para "Bcr-Abl".
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Imatinib Mesylate
CAS:Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR,Fórmula:C29H31N7O·CH4SO3Pureza:98% - >99.99%Cor e Forma:White SolidPeso molecular:589.71Dasatinib
CAS:Dasatinib (BMS-354825) is a tyrosine kinase inhibitor that inhibits Src and Bcr-Abl (Ki=16/30 pM) and is orally active and ATP-competitive.Fórmula:C22H26ClN7O2SPureza:99.59% - 99.86%Cor e Forma:Pale-Yellow SolidPeso molecular:488.01Lyn-IN-1
CAS:Lyn-IN-1 (Bafetinib analog) is a selective and potent dual inhibitor of Bcr-Abl and LynFórmula:C30H31F3N8OPureza:97% - 98.02%Cor e Forma:SolidPeso molecular:576.62Ref: TM-T11916
1mg38,00€2mg50,00€5mg79,00€1mL*10mM (DMSO)92,00€10mg117,00€25mg236,00€50mg371,00€100mg530,00€200mg770,00€Imatinib impurities3
CAS:Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.Fórmula:C24H20ClN5OPureza:98.63%Cor e Forma:SolidPeso molecular:429.9N-Desmethyl imatinib
CAS:N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.Fórmula:C28H29N7OPureza:98.60%Cor e Forma:SolidPeso molecular:479.58Ref: TM-T11641
1mg87,00€5mg166,00€1mL*10mM (DMSO)170,00€10mg303,00€25mg512,00€50mg737,00€100mg1.018,00€LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Fórmula:C25H25F3N4O4Pureza:98.30% - 99.92%Cor e Forma:White SolidPeso molecular:502.49Ref: TM-T11898
1mg50,00€5mg115,00€1mL*10mM (DMSO)128,00€10mg175,00€25mg344,00€50mg537,00€100mg653,00€200mg898,00€500mg1.369,00€Bosutinib
CAS:Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.Fórmula:C26H29Cl2N5O3Pureza:98.98% - 99.9%Cor e Forma:Yellow SolidPeso molecular:530.45Dasatinib monohydrate
CAS:Dasatinib monohydrate, an oral SRC-kinase inhibitor, counters imatinib-resistant chronic myeloid leukemia.Fórmula:C22H28ClN7O3SPureza:99.68% - >99.99%Cor e Forma:White SolidPeso molecular:506.03Nilotinib
CAS:Nilotinib (AMN107) is a Bcr-Abl tyrosine kinase inhibitor. Nilotinib has antitumor activity and may be used in CML. Cost-effective and quality-assured.Fórmula:C28H22F3N7OPureza:99.89% - >99.99%Cor e Forma:SolidPeso molecular:529.52AKE-72
CAS:AKE-72 is a Pan-BCR-ABL inhibitor with anti-leukemic activity.AKE-72 inhibits the proliferation of Ba/F3 cells expressing natural BCR-ABL or its T315I mutant.Fórmula:C30H29F3N6OPureza:99.91%Cor e Forma:SolidPeso molecular:546.59Ref: TM-T80676
1mg88,00€2mg129,00€5mg212,00€10mg310,00€25mg479,00€50mg642,00€100mg880,00€200mg1.161,00€SNIPER(ABL)-015
SNIPER(ABL)-015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5Fórmula:C58H70F3N9O9Pureza:98%Cor e Forma:SolidPeso molecular:1094.23SNIPER(ABL)-058
CAS:SNIPER(ABL)-058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL proteinFórmula:C62H75N11O9SPureza:98%Cor e Forma:SolidPeso molecular:1150.39PROTAC BCR-ABL Degrader-1
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1), featuring a 2-oxoethyl linker, promotes Bcr-Abl degradation through the ubiquitin-proteasome pathway andFórmula:C43H40N10O6Pureza:98%Cor e Forma:SolidPeso molecular:792.84ML 2-23
ML 2-23 is a potent BCR-ABL degrader operating as a PROTAC, exhibiting selective proteasome-dependent degradation of BCR-ABL within leukemia cells [1].Fórmula:C47H53BrCl2N10O7SPureza:98%Cor e Forma:SolidPeso molecular:1052.86Abl Cytosolic Substrate
CAS:Abl Cytosolic Substrate is a substrate for Abelson tyrosine kinase (Abl ).Fórmula:C64H101N15O16Pureza:98%Cor e Forma:SolidPeso molecular:1336.58DPH
CAS:DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation.Fórmula:C18H13FN4O2Pureza:99.65%Cor e Forma:SolidPeso molecular:336.32SNIPER(ABL)-050
SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.Fórmula:C68H84N12O9Pureza:98%Cor e Forma:SolidPeso molecular:1213.47Tyrosine Kinase Inhibitor Library
A unique collection of 1016 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase relatedCor e Forma:Odour SolidRef: TM-L2200
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRef: TM-L1600
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarSNIPER(ABL)-019
SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting aFórmula:C60H77ClN12O9SPureza:98%Cor e Forma:SolidPeso molecular:1177.85
