EGFR
Os inibidores do receptor do fator de crescimento epidérmico (EGFR) são compostos que bloqueiam a sinalização do EGFR, um receptor frequentemente superexpresso em vários tipos de câncer e que desempenha um papel crucial na angiogênese. Os inibidores de EGFR são usados para prevenir o crescimento e a metástase de tumores, interrompendo as vias que promovem a formação de vasos sanguíneos nos tumores. Esses inibidores são amplamente utilizados na pesquisa e terapia do câncer. Na CymitQuimica, oferecemos uma seleção diversificada de inibidores de EGFR de alta qualidade para apoiar sua pesquisa em oncologia e angiogênese.
Foram encontrados 598 produtos de "EGFR"
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Tyrphostin AG 879
CAS:Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Fórmula:C18H24N2OSPureza:99.05%Cor e Forma:SolidPeso molecular:316.46Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14NS309
CAS:NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.Fórmula:C8H4Cl2N2O2Pureza:97.55%Cor e Forma:SolidPeso molecular:231.04Cetuximab
CAS:Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM).Fórmula:C107H179N35O36S7Pureza:95 - 98.60%Cor e Forma:LiquidPeso molecular:152 kDaEndoxifen (Z-isomer)
CAS:Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.Fórmula:C25H27NO2Pureza:99.19% - 99.81%Cor e Forma:SolidPeso molecular:373.49Mubritinib
CAS:Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.Fórmula:C25H23F3N4O2Pureza:98.61% - 99.85%Cor e Forma:SolidPeso molecular:468.47Epitinib
CAS:<p>Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI).</p>Fórmula:C24H26N6O2Cor e Forma:SolidPeso molecular:430.5AG1557
CAS:<p>AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).</p>Fórmula:C16H14IN3O2Pureza:98.61% - 99.23%Cor e Forma:SolidPeso molecular:407.21E-4031 dihydrochloride
CAS:E-4031 dihydrochloride is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)Fórmula:C21H29Cl2N3O3SPureza:99.31% - 99.87%Cor e Forma:SolidPeso molecular:474.44Derazantinib dihydrochloride
CAS:Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.Fórmula:C29H31Cl2FN4OCor e Forma:SolidPeso molecular:541.49Tyrphostin AG 528
CAS:Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50: 4.9 μM) and ErbB2 (IC50: 2.1 μM).Fórmula:C18H14N2O3Pureza:99.64%Cor e Forma:SolidPeso molecular:306.32AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Fórmula:C16H18N2OPureza:98.12%Cor e Forma:SolidPeso molecular:254.33TAS0728
CAS:TAS0728 is a HER2 inhibitor, with antitumor activityFórmula:C26H32N8O3Pureza:97.78%Cor e Forma:SolidPeso molecular:504.58NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Fórmula:C24H26N4O3Pureza:99.90%Cor e Forma:SolidPeso molecular:418.49Theliatinib
CAS:<p>Theliatinib: potent, selective EGFR inhibitor, anti-tumor; Ki=0.05 nM (EGFR), IC50=3 nM (EGFR), 22 nM (T790M/L858R).</p>Fórmula:C25H26N6O2Pureza:99.67%Cor e Forma:SolidPeso molecular:442.51(E)-AG 99
CAS:(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).Fórmula:C10H8N2O3Pureza:99.23%Cor e Forma:SolidPeso molecular:204.18JCN037
CAS:JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).Fórmula:C16H11BrFN3O2Pureza:99.5%Cor e Forma:SolidPeso molecular:376.18PKI-166 hydrochloride
CAS:EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.Fórmula:C20H19ClN4OCor e Forma:SolidPeso molecular:366.85SU 4313
CAS:SU 4313 is a bioactive chemical.Fórmula:C18H17NOPureza:99.51% - 99.89%Cor e Forma:SolidPeso molecular:263.33EGFR/ErbB-2/ErbB-4 inhibitor-2
CAS:EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)Fórmula:C23H21N3O3Pureza:99.55%Cor e Forma:SolidPeso molecular:387.43
