EGFR
Os inibidores do receptor do fator de crescimento epidérmico (EGFR) são compostos que bloqueiam a sinalização do EGFR, um receptor frequentemente superexpresso em vários tipos de câncer e que desempenha um papel crucial na angiogênese. Os inibidores de EGFR são usados para prevenir o crescimento e a metástase de tumores, interrompendo as vias que promovem a formação de vasos sanguíneos nos tumores. Esses inibidores são amplamente utilizados na pesquisa e terapia do câncer. Na CymitQuimica, oferecemos uma seleção diversificada de inibidores de EGFR de alta qualidade para apoiar sua pesquisa em oncologia e angiogênese.
Foram encontrados 594 produtos de "EGFR"
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Sapitinib
CAS:Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib orFórmula:C23H25ClFN5O3Pureza:98.89% - 99.83%Cor e Forma:SolidPeso molecular:473.93Olmutinib
CAS:Olmutinib is an oral mutant-specific EGFR inhibitor for cancer treatment with potential lower toxicity.Fórmula:C26H26N6O2SPureza:99.14% - 99.63%Cor e Forma:SolidPeso molecular:486.59Cyasterone
CAS:Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promisingFórmula:C29H44O8Pureza:99.32% - 99.70%Cor e Forma:SolidPeso molecular:520.65Leptomycin B
CAS:Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.Fórmula:C33H48O6Pureza:97.10% - 99.04%Cor e Forma:White Crystalline SolidPeso molecular:540.73Genistein
CAS:<p>Genistein (NPI 031L) is a natural soy isoflavone, a multi-targeted tyrosine kinase inhibitor. Genistein has antitumor effects. Cost effective and quality assured.</p>Fórmula:C15H10O5Pureza:98.22% - 99.64%Cor e Forma:Rectangular Or Six-Sided Rods From 60% Alcohol Dendritic Needles From Ether SolidPeso molecular:270.24Rostafuroxin
CAS:Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.Fórmula:C23H34O4Pureza:98.24% - >99.99%Cor e Forma:SolidPeso molecular:374.51Almonertinib mesylate
CAS:Almonertinib mesylate: EGFR tyrosine kinase inhibitor, targets EGFR-mutant non-small cell lung cancer.Fórmula:C31H39N7O5SPureza:99.92%Cor e Forma:SolidPeso molecular:621.75(Rac)-JBJ-04-125-02
CAS:(Rac)-JBJ-04-125-02 (JBJ-04-125-02) is effective as a single agent in both in vitro and in vivo models of EGFR-mutant lung cancer.Fórmula:C29H26FN5O3SPureza:97.57%Cor e Forma:SolidPeso molecular:543.61Mobocertinib
CAS:Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agentFórmula:C32H39N7O4Pureza:99.47% - 99.97%Cor e Forma:SolidPeso molecular:585.7CUDC-101
CAS:CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.Fórmula:C24H26N4O4Pureza:95.76% - 99.17%Cor e Forma:SolidPeso molecular:434.49Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.9%Cor e Forma:Off-White SolidPeso molecular:485.94PD153035
CAS:PD153035 (NSC-669364) hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR,Fórmula:C16H14BrN3O2Pureza:98.47% - 99.29%Cor e Forma:SolidPeso molecular:360.21Nazartinib
CAS:Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (Fórmula:C26H31ClN6O2Pureza:98.63% - ≥95%Cor e Forma:Solid PowderPeso molecular:495.02PD-089828
CAS:<p>PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).</p>Fórmula:C18H18Cl2N6OPureza:97.39%Cor e Forma:SolidPeso molecular:405.28Gefitinib hydrochloride
CAS:Obtustatin triacetate is an integrin derived from the venom of Vipera lebetina obtusa and is an α1β1 integrin and in vivo angiogenesis inhibitor.Fórmula:C22H25Cl2FN4O3Pureza:99.8%Cor e Forma:SolidPeso molecular:483.36Cavutilide
CAS:<p>Cavutilide has antiarrhythmic activity, inhibits hERG K(+) channels, and can be used to study heart failure and persistent atrial fibrillation.</p>Fórmula:C22H26FN3O3Pureza:99.82% - 99.85%Cor e Forma:SolidPeso molecular:399.458Naquotinib mesylate
CAS:Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFRFórmula:C31H46N8O6SPureza:98%Cor e Forma:SolidPeso molecular:658.81BMS-690514
CAS:BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.Fórmula:C19H24N6O2Pureza:99.08%Cor e Forma:SolidPeso molecular:368.43Almonertinib hydrochloride
CAS:<p>Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation.</p>Fórmula:C30H36ClN7O2Pureza:98.01% - 98.12%Cor e Forma:SolidPeso molecular:562.1Canertinib dihydrochloride
CAS:Canertinib dihydrochloride (PD-183805 dihydrochloride) is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic andFórmula:C24H27Cl3FN5O3Pureza:99.13% - >99.99%Cor e Forma:SolidPeso molecular:558.86
