TNF
Gli inibitori del fattore di necrosi tumorale (TNF) sono composti che bloccano l'attività del TNF, una citochina coinvolta nell'infiammazione e nella regolazione dell'apoptosi. Il TNF può indurre l'apoptosi in alcuni tipi di cellule mentre promuove la sopravvivenza e l'infiammazione in altri. L'inibizione del TNF è cruciale nel trattamento delle malattie autoimmuni, delle condizioni infiammatorie croniche e di alcuni tipi di cancro. Gli inibitori del TNF aiutano a modulare la risposta immunitaria e a ridurre i danni ai tessuti causati da un'infiammazione eccessiva. Presso CymitQuimica, offriamo una vasta gamma di inibitori del TNF di alta qualità per supportare la tua ricerca in immunologia, infiammazione e apoptosi.
Foram encontrados 89 produtos de "TNF"
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Dacetuzumab
CAS:<p>Dacetuzumab (SGN 40) is a humanized anti-CD40 monoclonal antibody with antitumor activity for the study of recurrent diffuse large B-cell lymphoma.</p>Pureza:95.4% (SDS-PAGE); 99.1% (SEC-HPLC) - 95.4% (SDS-PAGE); 99.1% (SEC-HPLC)Cor e Forma:LiquidConatumumab
CAS:<p>Conatumumab (AMG 655) targets DR5 to induce apoptosis in tumors, with Kd of 1 nM (long DR5) and 0.8 nM (short DR5).</p>Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:145 kDa (average)(S,S)-TAPI-1 FA
(S,S)-TAPI-1 FA is a TNF-α processing inhibitor with potential anti-inflammatory effects, blocks TACE, and can inhibit TNF-α signaling can be used to study Staphylococcus aureus arthritis.Fórmula:C27H39N5O7Pureza:97.61% - 99.72%Cor e Forma:SolidPeso molecular:545.63Utomilumab
CAS:Utomilumab, a humanized IgG2 against T-cell receptor 4-1BB/CD137, shows antitumor effects in advanced cancers.Fórmula:C17H24N8O3Pureza:95% - 95.1% (SDS-PAGE); 98.5% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:142.77 kDaUCB-9260
CAS:<p>UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.</p>Fórmula:C26H25N5OPureza:98.39% - 99.24%Cor e Forma:SolidPeso molecular:423.51Certolizumab pegol
CAS:<p>Certolizumab pegol (Certolizumab) is a polyethylene glycolized and humanized anti-TNF-α monoclonal antibody.</p>Pureza:95% - 98.2% (SDS-PAGE); 99.1% (SEC-HPLC)Cor e Forma:LiquidEnavatuzumab
CAS:Enavatuzumab (PDL192) is a humanized monoclonal antibody targeting TWEAK receptor with anti-tumor activity.Pureza:>95%Cor e Forma:LiquidIscalimab
CAS:<p>Iscalimab (CFZ-533) is a humanized monoclonal antibody targeting CD40, used in research on myasthenia gravis and Sjögren’s syndrome.</p>Pureza:>95%Cor e Forma:LiquidRuplizumab
CAS:<p>PF-03732010 is a humanized antibody targeting P-calmodulin with antitumor and antimetastatic activity.</p>Pureza:98.5% (SDS-PAGE); 98.7% (SEC-HPLC) - 98.5% (SDS-PAGE); 98.7% (SEC-HPLC)Cor e Forma:LiquidLucatumumab
CAS:<p>Lucatumumab (HCD122) is a fully human anti-CD40 monoclonal antibody with anti-tumor activity for the study of multiple myeloma.</p>Pureza:95.5% (SDS-PAGE); 98.4% (SEC-HPLC) - 95.5% (SDS-PAGE); 98.4% (SEC-HPLC)Cor e Forma:LiquidOzoralizumab
CAS:<p>Ozoralizumab (ATN-103) is a humanized anti-TNFα antibody and a novel TNFα inhibitor.</p>Pureza:SDS-PAGE:> 95%;SEC-HPLC:95.6%Cor e Forma:LiquidPeso molecular:38.44 kDaTeneliximab
CAS:<p>Teneliximab (BMS 224819) is a chimeric monoclonal antibody that blocks CD40-CD40L interactions.Cost-effective and quality-assured.</p>Pureza:95.00% - 99.19% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:146.06 kDaLenercept
CAS:<p>Lenercept (Ro 45-2081) is a recombinant fusion protein combining the soluble TNF-receptor (p55) with the Fc portion of human IgG1 [1].</p>Cor e Forma:LiquidSotigalimab
CAS:Sotigalimab (APX 005) is a monoclonal antibody targeting CD40 with anticancer activity for the study of metastatic pancreatic cancer.Pureza:98.50% - 98.50%Cor e Forma:LiquidDSTYSLSSTLTLSK TFA
DSTYSLSSTLTLSK TFA detects infliximab, a chimeric IgG1 antibody targeting TNF-α.Fórmula:C66H108F3N15O28Cor e Forma:SolidPeso molecular:1616.64TNF-α (46-65), human
CAS:Human TNF alpha (46-65) peptide.Fórmula:C110H172N24O30Pureza:98%Cor e Forma:SolidPeso molecular:2310.69Zigakibart
CAS:<p>Zigakibart (BION-1301) is a humanized monoclonal antibody targeting TNFSF13 with anti-inflammatory activity for the study of immunoglobulin A nephropathy (IgAN)</p>Pureza:95.8% (SDS-PAGE); 99.8% (SEC-HPLC) - 95.8% (SDS-PAGE); 99.8% (SEC-HPLC)Cor e Forma:LiquidRagifilimab
CAS:<p>Ragifilimab (INCAGN-1876), a GITR-targeting agonist antibody, may treat advanced solid tumors.</p>Pureza:SDS-PAGE:95% SEC-HPLC:99.99%Cor e Forma:LiquidPeso molecular:146.46 kDaVarlilumab
CAS:<p>Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.</p>Pureza:SDS-PAGE:95% SEC-HPLC:98.65%Cor e Forma:LiquidPeso molecular:146 kDaTNF-α-IN-9
CAS:TNF-α-IN-9 is an NDM-1 inhibitor-3 analog and is a TNF-α inhibitor.TNF-α-IN-9 shows low inhibitory activity.Fórmula:C17H14O4Pureza:99.21%Cor e Forma:SoildPeso molecular:282.29Anti-Mouse TNF α Antibody (TN3-19.12)
<p>Anti-Mouse TNF alpha Antibody is a rat-derived IgG inhibitor targeting mouse TNF alpha.</p>Pureza:95% - ＞10mg/mlCor e Forma:Odour LiquidRO7567132
RO7567132 is a bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, inducing the formation of local TLS.Cor e Forma:Odour LiquidPamlectabart
Pamlectabart is a humanised antibody targeting TNFRSF17/BCMA, (ADC) Pamlectabart tismanitin multiple myeloma.Pureza:95%Cor e Forma:Odour LiquidRanevetmab
CAS:Ranevetmab (NV-01), a caninized anti-NGF mAb, relieves pain in DJD research.Cor e Forma:LiquidGiloralimab
CAS:Giloralimab (ABBV-927) is a antibody targeting CD40 with anticancer activity for the study of triple-negative breast cancer and non-small cell lung cancer.Pureza:95.6% (SDS-PAGE); 95.1% (SEC-HPLC) - 95.6% (SDS-PAGE); 95.1% (SEC-HPLC)Cor e Forma:LiquidAtibuclimab
CAS:<p>Atibuclimab is a chimeric monoclonal antibody targeting CD14, consisting of a mouse variable region and a human IgG4 Fc region.</p>Pureza:> 95% - > 95%Cor e Forma:LiquidPeso molecular:145.28 kDaSym029
Sym029 is a human IgG monoclonal antibody (mAb) that targets TNFRSF5/CD40. It is applicable for cancer research. The suggested isotype control is Human IgG1 kappa, Isotype Control.BIIB023
BIIB023 is a human monoclonal antibody (mAb) that targets TNFRSF12A/TWEAKR/CD266. It is applicable for research in lupus nephritis and rheumatoid arthritis.Cor e Forma:Odour LiquidDazodalibep
CAS:Dazodalibep (MEDI 4920; VIB 4920) is a monoclonal antibody that specifically targets CD40LG/TNFSF5 and is fused to human serum albumin (ALB/HSA) [1].Cor e Forma:LiquidTNF-α Antagonist
CAS:<p>TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with</p>Fórmula:C58H71N11O15S2Cor e Forma:SolidPeso molecular:1226.39Tilogotamab
CAS:Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).Pureza:95%Cor e Forma:LiquidOnfekafusp alfa
CAS:<p>Onfekafusp alfa (L19TNF), a trimeric fusion of L19 scFv and human TNF, targets malignant glioma.</p>Cor e Forma:LiquidTengonermin
CAS:Tengonermin (ARENEGYR), a vascular agent, is TNF-α fused with CNGRCG peptide, enhancing chemo and T-cell access in tumors.Cor e Forma:LiquidPegsunercept
CAS:<p>Pegsunercept (PEG sTNF-RI), a pegylated monoclonal antibody, selectively binds to TNFA, incorporating a polyethylene glycol (pegol) moiety [1].</p>Cor e Forma:LiquidNerelimomab
CAS:Nerelimomab (BAYX1351), an anti-TNF-α antibody, is utilized in sepsis research [1] [2].Cor e Forma:LiquidEJMC-1
CAS:<p>EJMC-1 is an inhibitor of TNF-α with an IC50 value of 42 μM and can be used in studies about auto-inflammatory diseases.</p>Fórmula:C17H11ClN2O4SPureza:98.38%Cor e Forma:SolidPeso molecular:374.8HS-243
CAS:<p>HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.</p>Fórmula:C17H16N4O3Pureza:98.62%Cor e Forma:SolidPeso molecular:324.33Asunercept
CAS:<p>Asunercept (APG101/CAN008) is a CD95-Fc protein targeting CD95L, used in GBM, MDS, and GvHD research.</p>Cor e Forma:LiquidDapirolizumab
<p>Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.</p>Pureza:>95%Cor e Forma:LiquidPeso molecular:145.5 kDaBMS-986156
BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody that targets the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR). It binds to GITR and enhances the activation of T effector cells while deactivating T regulatory cells. BMS-986156 is applicable for research in advanced solid tumors.Tanfanercept
CAS:<p>Tanfanercept (HL036337) is an anti-TNF-α antibody, improving corneal erosions in dry eye mice.</p>Cor e Forma:LiquidPlaculumab
CAS:Placulumab (ART621), an anti-TNF α monoclonal antibody, targets inflammation, potentially aiding arthritis treatment.Cor e Forma:LiquidTNF α Protein, Human, Recombinant (aa 77-233, His)
TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E.Pureza:Greater than 95% as determined by reducing SDS-PAGE - SDS-PAGE: 99.66%; SEC-HPLC: 96.3%Cor e Forma:Lyophilized PowderPeso molecular:16 KDa (reducing condition)TNF α Protein, Rabbit, Recombinant
<p>Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily.</p>Pureza:98% - > 99.9%Cor e Forma:Lyophilized PowderPeso molecular:18 KDa (reducing condition)TNF α Protein, Ferret, Recombinant (His)
TNF alpha Protein, Ferret, Recombinant (His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:18.88 kDa (predicted) same as Tris-Bis PAGE result.TNF α Protein, Human, Recombinant (His & Avi)
TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Cor e Forma:Lyophilized PowderPeso molecular:20.3 kDa (predicted). Due to glycosylation, the protein migrates to 21-25 kDa based on Tris-Bis PAGE result.TNF α Protein, Human, Recombinant (His & Avi), Biotinylated
<p>TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.</p>Cor e Forma:Lyophilized PowderPeso molecular:20.3 kDa (predicted). Due to glycosylation, the protein migrates to 21-24 kDa based on Tris-Bis PAGE result.TNF α Protein, Cynomolgus, Recombinant (His)
TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag.Cor e Forma:Lyophilized PowderPeso molecular:18.35 kDa (predicted). Due to glycosylation, the protein migrates to 19-25 kDa based on Tris-Bis PAGE result.TNF α Protein, Human, Recombinant (aa 57-233, His)
TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E.Cor e Forma:Lyophilized PowderPeso molecular:18 KDa (reducing condition)LASSBio-1135
CAS:LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.Fórmula:C18H14N4Pureza:99.09%Cor e Forma:SolidPeso molecular:286.33R-7050
CAS:<p>R-7050 (TNF-α Antagonist III), a tumor necrosis factor receptor (TNFR) antagonist, exhibits heightened selectivity for TNFα.</p>Fórmula:C16H8ClF3N4SPureza:98.64% - 99.8%Cor e Forma:SolidPeso molecular:380.77(Rac)-Benpyrine
CAS:(Rac)-Benpyrine is a potent and orally active inhibitor of TNF-α.Fórmula:C16H16N6OPureza:98.44%Cor e Forma:SolidPeso molecular:308.34Hispidol
CAS:<p>Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon</p>Fórmula:C15H10O4Pureza:97.86% - 98.45%Cor e Forma:SolidPeso molecular:254.24STING-IN-2
CAS:STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. STING-IN-2 can be used for autoinflammatory disease research.Fórmula:C15H16N2O4Pureza:98.61%Cor e Forma:SolidPeso molecular:288.3Roquinimex
CAS:Roquinimex (FCF89) (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis andFórmula:C18H16N2O3Pureza:97.69%Cor e Forma:SolidPeso molecular:308.33C25-140
CAS:<p>C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.</p>Fórmula:C26H31N7OPureza:98.81%Cor e Forma:SolidPeso molecular:457.57Resatorvid
CAS:<p>Resatorvid (TAK-242) inhibits TLR4, with IC50s for IL-6, TNF-R, NO at 1.3, 1.9, 1.8 nM respectively.</p>Fórmula:C15H17ClFNO4SPureza:99.31% - >99.99%Cor e Forma:SolidPeso molecular:361.82UTL-5g
CAS:<p>UTL-5g is a chemoprotective TNF-α inhibitor reducing cisplatin side effects and toxicity in liver, kidneys, and blood.</p>Fórmula:C11H8Cl2N2O2Pureza:99.83%Cor e Forma:SolidPeso molecular:271.1Tulisokibart
CAS:<p>Tulisokibart (PRA023) is a humanized anti-TNFSF15 monoclonal antibody used to study colon cancer.</p>Pureza:98.38% (SEC-HPLC) - > 95%Cor e Forma:LiquidDalnicastobart
CAS:Dalnicastobart (LVGN-7409) is a humanized monoclonal antibody targeting CD40/TNFRSF5 with agonist activity, immunostimulatory and antitumor.Pureza:95% - 97.4% (SDS-PAGE); 97.8% (SEC-HPLC)Cor e Forma:LiquidCifurtilimab
CAS:<p>Cifurtilimab (SEA-CD40) is a humanised monoclonal antibody acting as a CD40 agonist. It enhances binding to activated FcγRIIIa, anticancer.</p>Pureza:95%Cor e Forma:LiquidAfimkibart
CAS:Afimkibart (PF06480605) is a humanised monoclonal antibody targeting TL1A (TNF-like Ligand 1A), which blocks TL1A-DR3 (death domain receptor 3) signalling on restrictive immune cells and fibroblasts. It can be used for inflammatory bowel disease and ulcerative colitis.Pureza:95% - 99.2% (SDS-PAGE); 95.3% (SEC-HPLC)Cor e Forma:SoildToralizumab
CAS:<p>Toralizumab: humanized mAb targeting CD40L to curb T cell signaling and explore SLE treatment.</p>Cor e Forma:LiquidPeso molecular:148.43 (kD)Ravagalimab
CAS:Ravagalimab (ABBV-323) is a CD40 antagonist monoclonal antibody, investigated for Crohn’s disease and Sjögren’s syndrome to evaluate immune modulation.Pureza:95% - 96.9% (SDS-PAGE); 99.5% (SEC-HPLC)Cor e Forma:LiquidIvuxolimab
CAS:<p>Ivuxolimab is a human IgG2 antibody that acts as an OX40 agonist, promoting T cell responses for anti-tumor immunity research.</p>Pureza:95% - 95%Cor e Forma:LiquidIratumumab
CAS:Iratumumab (MDX-060), a human IgG1κ anti-CD30 monoclonal antibody, halts CD30+ tumor growth, used in HL and ALCL research.Cor e Forma:LiquidBleselumab
CAS:Bleselumab (ASKP 1240) is a humanised monoclonal antibody targeting CD40, inhibiting immune responses, organ transplant rejection.Pureza:95%Cor e Forma:LiquidTabalumab
CAS:Tabalumab (LY2127399) is a humanised monoclonal antibody targeting BAFF that neutralises both soluble and membrane-bound forms of BLyS , autoimmune diseases.Pureza:95%Cor e Forma:LiquidLicaminlimab
<p>Licaminlimab (OCS-02) is a single-chain antibody fragment targeting TNF alpha, an inflammatory cytokine.</p>Cor e Forma:Odour LiquidAnti-Mouse TNFR2 Antibody (TR75-54.7)
Anti-Mouse TNFR2 Antibody is an Armenian Hamster-derived IgG inhibitor specifically targeting mouse TNFR2.Cor e Forma:Odour LiquidTecaginlimab
CAS:Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, targets CD40/4-1BB to boost tumor immunity.Cor e Forma:LiquidAfelimomab
CAS:<p>Afelimomab (MAK 195F), a F(ab')2 fragment of an anti-tumor necrosis factor monoclonal antibody, is utilized in sepsis research [1].</p>Cor e Forma:LiquidFrexalimab
CAS:Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1].Pureza:95% - 95%Cor e Forma:LiquidSelicrelumab
CAS:Selicrelumab (RG-7876) is an antibody targeting CD40 with potential anti-tumor activity for the study of pancreatic cancer.Pureza:98.7% (SDS-PAGE); 95.2% (SEC-HPLC) - 98.7% (SDS-PAGE); 95.2% (SEC-HPLC)Cor e Forma:LiquidVU0285655-1
CAS:<p>VU0285655-1, a PLD2 inhibitor, halts PLD2-deficient cell growth and protects against high glucose-induced cell death. Used in diabetic retinopathy research.</p>Fórmula:C25H27N5O2Pureza:99.73%Cor e Forma:SolidPeso molecular:429.51TNF-α-IN-1
CAS:TNF-α-IN-1 is a TNF-α inhibitor.Fórmula:C16H14ClN3O5Pureza:98.82%Cor e Forma:SolidPeso molecular:363.75UCB-5307
CAS:UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.Fórmula:C22H21N3OPureza:98.76%Cor e Forma:SolidPeso molecular:343.42SPD304 dihydrochloride
CAS:<p>SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.</p>Fórmula:C32H34Cl2F3N3O2Pureza:99.25%Cor e Forma:SolidPeso molecular:620.53Mitazalimab
CAS:<p>Mitazalimab (ADC-1013/JNJ-64457107) is a CD40 agonist that stimulates T cells to attack tumors and remodels the tumor microenvironment.</p>Pureza:95.1% (SDS-PAGE); 98.7% (SEC-HPLC) - 95.1% (SDS-PAGE); 98.7% (SEC-HPLC)Cor e Forma:LiquidTrovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.46BMS-561392
CAS:BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.Fórmula:C27H32N4O4Pureza:99.16%Cor e Forma:SolidPeso molecular:476.57Boserolimab
CAS:<p>Boserolimab (MK-5890) is a chimeric, humanized IgG1κ antibody that targets the signaling regulatory protein CD27 in mice.</p>Cor e Forma:LiquidC 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Fórmula:C24H15ClN6O3SPureza:≥98%Cor e Forma:SolidPeso molecular:502.93PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Fórmula:C22H24N4O3SPureza:98.09% - 99.64%Cor e Forma:SolidPeso molecular:424.52CDC801
CAS:<p>CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.</p>Fórmula:C23H24N2O5Pureza:99.61%Cor e Forma:SolidPeso molecular:408.45TNF-α-IN-14
CAS:TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].Fórmula:C22H26O6Cor e Forma:SolidPeso molecular:386.44TNF-α-IN-2
CAS:TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.Fórmula:C25H21ClF2N6OPureza:99.92%Cor e Forma:SolidPeso molecular:494.92TNF-α-IN-12
CAS:<p>TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].</p>Fórmula:C21H22O6Cor e Forma:SolidPeso molecular:370.4
