TNF
Gli inibitori del fattore di necrosi tumorale (TNF) sono composti che bloccano l'attività del TNF, una citochina coinvolta nell'infiammazione e nella regolazione dell'apoptosi. Il TNF può indurre l'apoptosi in alcuni tipi di cellule mentre promuove la sopravvivenza e l'infiammazione in altri. L'inibizione del TNF è cruciale nel trattamento delle malattie autoimmuni, delle condizioni infiammatorie croniche e di alcuni tipi di cancro. Gli inibitori del TNF aiutano a modulare la risposta immunitaria e a ridurre i danni ai tessuti causati da un'infiammazione eccessiva. Presso CymitQuimica, offriamo una vasta gamma di inibitori del TNF di alta qualità per supportare la tua ricerca in immunologia, infiammazione e apoptosi.
Foram encontrados 144 produtos para "TNF".
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MK-4166
MK-4166 is a humanized IgG1 agonistic monoclonal antibody targeting GITR. It is capable of enhancing the proliferation of both naive T lymphocytes and tumor-infiltrating T lymphocytes.Cor e Forma:Odour LiquidTulinercept
CAS:Tulinercept (OPRX-106), a monoclonal antibody, may be utilized in a range of biochemical research applications [1].Cor e Forma:LiquidTQB2916
TQB2916 is a humanized IgG2 monoclonal antibody agonist that targets CD40. It exhibits significant antitumor activity by occupying CD40 and activating immune function. TQB2916 is applicable for research in advanced solid tumors and lymphomas.Cor e Forma:Odour LiquidXmAb-2513
XmAb-2513 is a humanized monoclonal antibody inhibitor targeting CD30. It demonstrates significant anti-proliferative activity along with excellent antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). XmAb-2513 is applicable in research on hematological malignancies such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL).Cor e Forma:Odour LiquidMK-1248
MK-1248 is a human IgG4 monoclonal antibody (mAb) targeting TNFSF18. It enhances the proliferative response of tumor-infiltrating lymphocytes to anti-CD3 stimulation and promotes the production of anti-tumor associated regulatory cytokines. MK-1248 is utilized in research on solid tumors.Cor e Forma:Odour LiquidGSK2800528
GSK2800528 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa, utilized for research related to inflammation and psoriasis.Cor e Forma:Odour LiquidGB-223
GB-223 is a human monoclonal antibody (mAb) that targets TNFSF11/RANKL/CD254. It is applicable in the study of giant cell tumors of bone and postmenopausal osteoporosis.Cor e Forma:Odour LiquidIBI356
IBI356 is a humanized monoclonal antibody inhibitor that targets OX40L/CD134L/CD252. It can be utilized in the study of chronic inflammatory skin diseases, such as atopic dermatitis.Cor e Forma:Odour LiquidMitazalimab
CAS:Mitazalimab (ADC-1013/JNJ-64457107) is a CD40 agonist that stimulates T cells to attack tumors and remodels the tumor microenvironment.Pureza:95.1% (SDS-PAGE); 98.7% (SEC-HPLC) - 95.1% (SDS-PAGE); 98.7% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:143.42 kDa (Predicted)SPD304 dihydrochloride
CAS:SPD304 dihydrochloride is a selective inhibitor of TNF-α with an IC50 of 22 µM. SPD304 dihydrochloride promotes dissociation of TNF trimers.Fórmula:C32H34Cl2F3N3O2Pureza:99.25%Cor e Forma:SolidPeso molecular:620.53UCB-5307
CAS:UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.Fórmula:C22H21N3OPureza:98.76%Cor e Forma:White SolidPeso molecular:343.4216Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.46PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Fórmula:C22H24N4O3SPureza:98.09% - 99.64%Cor e Forma:SolidPeso molecular:424.516C 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Fórmula:C24H15ClN6O3SPureza:≥98%Cor e Forma:Orange SolidPeso molecular:502.932Certolizumab pegol
CAS:Certolizumab pegol (Certolizumab) is a polyethylene glycolized and humanized anti-TNF-α monoclonal antibody.Pureza:96.7% (SDS-PAGE); 96.5% (SEC-HPLC) - 99%Cor e Forma:Transparent LiquidPeso molecular:47.74 kDa (Predicted)TNF-α-IN-2
CAS:TNF-α-IN-2 is orally active TNFα inhibitor that distorts the TNFα trimer, causing abnormal signal transduction when it binds to TNFR1, rheumatoid arthritis.Fórmula:C25H21ClF2N6OPureza:99.92%Cor e Forma:Pink SolidPeso molecular:494.924TNF-α-IN-14
CAS:TNF-α-IN-14, a potent TNFα inhibitor, exhibits a selective inhibition profile with an IC50 of 1.1 µM and demonstrates antiinflammatory properties (WO2001072735A2; compound 12) [1].Fórmula:C22H26O6Cor e Forma:SolidPeso molecular:386.44Balinatunfib
CAS:Balinatunfib (SAR-441566) is an orally active and highly selective inhibitor of TNFR1 signaling that exerts its mechanism of action by binding to the central pocket of the soluble TNFα (sTNFα) trimer, stabilizing an asymmetric and inactive conformation that selectively blocks interaction with TNFR1 without affecting TNFR2, Balinatunfib suppresses downstream proinflammatory signaling cascades and demonstrating robust anti-inflammatory activity suitable for mechanistic and translational research in autoimmune and inflammatory diseases.Fórmula:C27H24F2N6O2Pureza:99.20%Cor e Forma:Orange SolidPeso molecular:502.52BMS-561392
CAS:BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.Fórmula:C27H32N4O4Pureza:99.16%Cor e Forma:SolidPeso molecular:476.57TNF-α-IN-12
CAS:TNF-α-IN-12, a TNF-α inhibitor with an IC50 of 0.1 μM, can reduce TNF-α blood levels [1].Fórmula:C21H22O6Cor e Forma:SolidPeso molecular:370.4
