BCL
Os inibidores de BCL são compostos que têm como alvo a família de proteínas BCL-2, que desempenham um papel fundamental na regulação da apoptose. A família BCL-2 inclui membros pró-apoptóticos e anti-apoptóticos que controlam a via mitocondrial da apoptose. Inibir proteínas BCL-2 anti-apoptóticas pode promover a morte celular em células cancerígenas, tornando os inibidores de BCL cruciais na pesquisa de terapias contra o câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de BCL de alta qualidade para apoiar sua pesquisa em câncer, apoptose e biologia celular.
Foram encontrados 11 produtos de "BCL"
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BM 957
CAS:<p>BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).</p>Fórmula:C52H56ClF3N6O7S3Pureza:98%Cor e Forma:SolidPeso molecular:1065.68Mcl-1 inhibitor 3
CAS:<p>Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate</p>Fórmula:C40H52ClF2N5O7SPureza:98%Cor e Forma:SolidPeso molecular:820.39PROTAC Bcl2 degrader-1
CAS:<p>PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).</p>Fórmula:C45H45BrN6O10SPureza:98%Cor e Forma:SolidPeso molecular:941.84Mcl1-IN-12
CAS:<p>Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.</p>Fórmula:C45H46N4O6S2Pureza:98%Cor e Forma:SolidPeso molecular:803Pyridoclax
CAS:<p>Pyridoclax is an inhibitor of potential Mcl-1.</p>Fórmula:C29H22N4Pureza:98%Cor e Forma:SolidPeso molecular:426.51S55746 hydrochloride
CAS:<p>S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.</p>Fórmula:C43H43ClN4O6Pureza:98%Cor e Forma:SolidPeso molecular:747.28Tapotoclax
CAS:<p>Tapotoclax (AMG-176) is an orally active MCL1 inhibitor for the study of myeloid leukemia.</p>Fórmula:C33H41ClN2O5SPureza:98.8%Cor e Forma:SolidPeso molecular:613.21MCL-1/BCL-2-IN-1
CAS:<p>MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].</p>Fórmula:C31H27BrN2O3SPureza:98%Cor e Forma:SolidPeso molecular:587.53Mcl1-IN-11
CAS:<p>Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.</p>Fórmula:C38H41N3O5S2Pureza:98%Cor e Forma:SolidPeso molecular:683.88Mcl1-IN-9
CAS:<p>Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.</p>Fórmula:C37H39ClN4O4Pureza:98%Cor e Forma:SolidPeso molecular:639.18WEHI-539 hydrochloride
CAS:<p>WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.</p>Fórmula:C31H30ClN5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:620.18
