Integrinas
Os inibidores de integrinas têm como alvo as integrinas, uma família de receptores de superfície celular que desempenham um papel crucial na adesão celular, migração e transdução de sinais. As integrinas estão envolvidas na regulação do ciclo celular, particularmente em processos como divisão e diferenciação celular. Inibir integrinas pode interromper esses processos, levando à parada do ciclo celular e apoptose, tornando esses inibidores valiosos na pesquisa do câncer e no estudo da metástase. Na CymitQuimica, oferecemos uma ampla gama de inibidores de integrinas de alta qualidade para apoiar sua pesquisa em regulação do ciclo celular, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 256 produtos de "Integrinas"
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Sibrafiban
CAS:Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Fórmula:C20H28N4O6Cor e Forma:SolidPeso molecular:420.46GSK-3008348
CAS:GSK-3008348 is an antagonist of integrin alpha(v)beta6.Fórmula:C29H37N5O2Pureza:99.547%Cor e Forma:SolidPeso molecular:487.64RUC-1
CAS:RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.Fórmula:C11H15N5OSPureza:98%Cor e Forma:SolidPeso molecular:265.33Valategrast
CAS:Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.Fórmula:C30H32Cl3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:604.95Integrin-IN-2
CAS:Integrin-IN-2, an oral αv integrin blocker, enhances αvβ6/3/5/8 affinities with pIC50s: 7.8/8.4/8.4/7.4.Fórmula:C27H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:458.55IS-741 calcium
CAS:IS-741 calcium is a phospholipase A2 inhibitor.Fórmula:C30H38CaF6N6O6S2Cor e Forma:SolidPeso molecular:796.86BMS-688521
CAS:BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Fórmula:C26H19Cl2N5O4Pureza:98.87%Cor e Forma:SolidPeso molecular:536.37CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Fórmula:C19H17N3O4Pureza:99.89%Cor e Forma:SolidPeso molecular:351.36Integrin modulator 1
CAS:Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.Fórmula:C13H14N2O4Pureza:99.61%Cor e Forma:SolidPeso molecular:262.26Valategrast hydrochloride
CAS:Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Fórmula:C30H33Cl4N3O4Pureza:98%Cor e Forma:SolidPeso molecular:641.41TCS 2314
CAS:TCS 2314 is an orally active and selective very late antigen-4 antagonist (IC50: 4.4 nM).Fórmula:C28H34N4O6Pureza:98%Cor e Forma:SolidPeso molecular:522.59Zaurategrast ethyl ester sulfate
CAS:Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.Fórmula:C56H60Br2N8O10SPureza:98%Cor e Forma:SolidPeso molecular:1197.01Zaurategrast ethyl ester
CAS:Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.Fórmula:C28H29BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.46IMB-10
CAS:IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.Fórmula:C19H15NOS2Cor e Forma:SolidPeso molecular:337.46Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFórmula:C27H27F2NO6Pureza:99.67%Cor e Forma:SolidPeso molecular:499.5Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Fórmula:C22H32N4O4Pureza:98.76%Cor e Forma:SolidPeso molecular:416.51αvβ1 integrin-IN-2
CAS:<p>αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.</p>Fórmula:C29H38N4O4Pureza:98%Cor e Forma:SolidPeso molecular:506.64Bexotegrast HCl
CAS:Bexotegrast (PLN-74809) inhibits αVβ1/αVβ6 integrins, preventing TGF-β1 activation to treat IPF and PSC.Fórmula:C27H38Cl2N6O3Cor e Forma:SolidPeso molecular:565.543-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFórmula:C13H8O3Pureza:98%Cor e Forma:SolidPeso molecular:212.2ICAM-1-IN-1
CAS:<p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>Fórmula:C15H11BrN2O2SPureza:99.67%Cor e Forma:SolidPeso molecular:363.23TAK 029
CAS:TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Fórmula:C19H23N5O7Cor e Forma:SolidPeso molecular:433.42Lamifiban
CAS:Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.Fórmula:C24H28N4O6Pureza:98%Cor e Forma:SolidPeso molecular:468.5SC-52012
CAS:<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Fórmula:C25H30N4O6Pureza:97.20%Cor e Forma:SolidPeso molecular:482.53L 738167
CAS:L 738167 is a potent antagonist of the long-acting fibrinogen receptor.Fórmula:C25H34N6O6SCor e Forma:SolidPeso molecular:546.64α7β1 integrin modulator-1
CAS:α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Fórmula:C23H29N3O6SPureza:98%Cor e Forma:SolidPeso molecular:475.56JNJ-26076713
CAS:JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Fórmula:C29H38N4O3Pureza:98%Cor e Forma:SolidPeso molecular:490.64SB-267268
CAS:SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).Fórmula:C22H24F3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:451.44Zaurategrast
CAS:Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.Fórmula:C26H25BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:521.41Carotegrast
CAS:Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.Fórmula:C27H24Cl2N4O5Cor e Forma:SolidPeso molecular:555.41Tirofiban HCl
CAS:<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Fórmula:C22H37ClN2O5SPureza:98%Cor e Forma:SolidPeso molecular:477.06Integrin Antagonists 27
CAS:Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Fórmula:C24H20N4O5Cor e Forma:SolidPeso molecular:444.44αvβ6 integrin inhibitor 2
CAS:αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.Fórmula:C21H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:386.49Synstatin (92-119)
CAS:Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFórmula:C133H207N35O46Pureza:98%Cor e Forma:SolidPeso molecular:3032.27L-739758
CAS:L-739758 is a glycoprotein IIb/IIIa inhibitor.Fórmula:C22H26N4O5S3Cor e Forma:SolidPeso molecular:522.66TC-I 15
CAS:α2β1 integrin inhibitorFórmula:C23H28N4O6S2Pureza:98%Cor e Forma:SolidPeso molecular:520.62BIO-7662
CAS:BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.Fórmula:C38H48N6O8SPureza:98%Cor e Forma:SolidPeso molecular:748.89Gly-Arg-Gly-Asp-Ser TFA
CAS:Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.Fórmula:C19H31F3N8O11Cor e Forma:SolidPeso molecular:604.49Solitomab
CAS:Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.Pureza:95%Cor e Forma:LiquidLotrafiban
CAS:Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.Fórmula:C23H32N4O4Cor e Forma:SolidPeso molecular:428.52Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Pureza:95%Cor e Forma:LiquidLotrafiban hydrochloride
CAS:Lotrafiban hydrochloride is an platelet glycoprotein IIb/IIIa blocker with oral activity.Fórmula:C23H33ClN4O4Cor e Forma:SolidPeso molecular:464.99BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Fórmula:C32H26Cl2FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:646.5ATN-161
CAS:ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Fórmula:C23H35N9O8SPureza:98%Cor e Forma:SolidPeso molecular:597.64αvβ1 integrin-IN-1
CAS:<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Fórmula:C26H34N6O6SPureza:99.74% - >99.99%Cor e Forma:SolidPeso molecular:558.65Roxifiban acetate
CAS:Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFórmula:C23H33N5O8Pureza:97.91% - 98.36%Cor e Forma:SolidPeso molecular:507.54L 734217
CAS:L 734217 is an antagonist of the fibrinogen receptor.Fórmula:C18H31N3O4Pureza:98%Cor e Forma:SolidPeso molecular:353.46Des-ethyl-carafiban
CAS:Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.Fórmula:C22H23N5O5Cor e Forma:SolidPeso molecular:437.4486-B345TTQ
CAS:6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.Fórmula:C22H20BrNO4Cor e Forma:SolidPeso molecular:442.303α5β1 integrin agonist-1
CAS:α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.Fórmula:C24H26FN5O9Cor e Forma:SolidPeso molecular:547.49SF0166
CAS:SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.Fórmula:C23H27F2N5O4Cor e Forma:SolidPeso molecular:475.49Zalunfiban dihydrochloride
Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.Fórmula:C16H20Cl2N8O2SCor e Forma:SolidPeso molecular:459.35OPN expression inhibitor 1
CAS:OPN expression inhibitor 1 is an osteopontin expression inhibitor used in the study of breast cancer metastasis.Fórmula:C25H33N3O5Pureza:99.78%Cor e Forma:SolidPeso molecular:455.55Fradafiban
CAS:Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.Fórmula:C20H21N3O4Pureza:98%Cor e Forma:SolidPeso molecular:367.40GSK3335103
CAS:GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Fórmula:C27H36FN3O4Cor e Forma:SolidPeso molecular:485.59SR121566A
CAS:SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).Fórmula:C20H25N5O4SPureza:98%Cor e Forma:SolidPeso molecular:431.51GR 83895
CAS:GR 83895 is an antagonist of prototype fibrinogen receptor.Fórmula:C29H39N9O8SPureza:98%Cor e Forma:SolidPeso molecular:673.74
