Integrinas
Os inibidores de integrinas têm como alvo as integrinas, uma família de receptores de superfície celular que desempenham um papel crucial na adesão celular, migração e transdução de sinais. As integrinas estão envolvidas na regulação do ciclo celular, particularmente em processos como divisão e diferenciação celular. Inibir integrinas pode interromper esses processos, levando à parada do ciclo celular e apoptose, tornando esses inibidores valiosos na pesquisa do câncer e no estudo da metástase. Na CymitQuimica, oferecemos uma ampla gama de inibidores de integrinas de alta qualidade para apoiar sua pesquisa em regulação do ciclo celular, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 289 produtos para "Integrinas".
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ATN-161 acetate
CAS:ATN-161 acetate, a pentapeptide compound derived from the synergistic region of fibronectin, is an integrin-alpha5 antagonist with antitumor activity.Fórmula:C25H39N9O10SPureza:98.27%Cor e Forma:White SolidPeso molecular:657.7Vedolizumab
CAS:Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.Pureza:SDS-PAGE:98.4%;SEC-HPLC:99.1%Cor e Forma:LiquidPeso molecular:146.80 kDaBersanlimab
CAS:Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties.Pureza:> 95% - > 95%Cor e Forma:Transparent LiquidPeso molecular:144.22 kDaFuzapladib
CAS:Fuzapladib (IS-741) is a PLA2 inhibitor that reduces Mac-1 expression to prevent inflammation and pancreatitis.Fórmula:C15H20F3N3O3SPureza:99.87%Cor e Forma:SolidPeso molecular:379.4Ref: TM-T67749
1mg60,00€5mg138,00€1mL*10mM (DMSO)177,00€10mg200,00€25mg424,00€50mg618,00€100mg802,00€ATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Fórmula:C25H36F3N9O10SPureza:98% - 99.98%Cor e Forma:White SolidPeso molecular:711.67Tadocizumab
CAS:Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Pureza:97.1% (SDS-PAGE); 97.2% (SEC-HPLC) - 97.1% (SDS-PAGE); 97.2% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:47.59 kDaForalumab
CAS:Foralumab (NI-0401) is a human anti-CD3 monoclonal antibody for the study of COVID-19 infection.Pureza:96.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 96.4% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:146.59 kDaTidutamab
CAS:Tidutamab (XmAb-18087) is a humanized bispecific antibody targeting the growth inhibitory receptor 2 (SSTR2) and T cell binding domain (CD3).Pureza:97.9% (SDS-PAGE); 97.8% (SEC-HPLC) - 97.9% (SDS-PAGE); 97.8% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:197.74 kDaTeplizumab
CAS:Teplizumab (MGA-031) is a humanized monoclonal antibody against CD3 that slows the loss of beta cell function.Teplizumab is used to treat type 1 diabetes.Pureza:SDS-PAGE:95.8%;SEC-HPLC:99.7%Cor e Forma:LiquidPeso molecular:145.79 kDaAbciximab
CAS:Abciximab: chimeric antibody, anti-platelet, blocks glycoprotein IIb/IIIa, vitronectin, Mac-1.Pureza:SDS-PAGE:95.2%;SEC-HPLC:95.9%Cor e Forma:Transparent LiquidPeso molecular:95.18 kDaCibisatamab
CAS:Cibisatamab, a T-cell bispecific antibody, targets CEA on cancer cells and CD3 on T-cells, inducing T-cell-mediated tumor cell killing.Pureza:SDS-PAGE:99.1%;SEC-HPLC:96.5%Cor e Forma:Transparent LiquidPeso molecular:191.1 kDaK34c hydrochloride
CAS:K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.Fórmula:C26H30ClN3O4Pureza:99.76% - 99.89%Cor e Forma:White SolidPeso molecular:483.99Otelixizumab
CAS:Otelixizumab (ChAglyCD3) is a chimeric monoclonal antibody targeting CD3, used in research on Type 1 diabetes and autoimmune diseases.Pureza:>95%Cor e Forma:Transparent LiquidPeso molecular:144.58 kDaArg-Gly-Asp-Ser acetate
Arg-Gly-Asp-Ser acetate targets integrin, binding pro-caspase-8, -9, -3, but not -1; inhibits receptor function.Fórmula:C17H31N7O10Pureza:99.92%Cor e Forma:SolidPeso molecular:493.47RWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Fórmula:C18H17F3N4O2SPureza:99.09%Cor e Forma:White SolidPeso molecular:410.41Ref: TM-T12783
1mg120,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg447,00€25mg707,00€50mg964,00€100mg1.243,00€200mg1.693,00€Abituzumab
CAS:Abituzumab (DI17E6) is a humanized monoclonal antibody targeting integrin alphaV, exhibiting anti-cancer activity and can be used in prostate cancer research.Pureza:>95%Cor e Forma:Transparent LiquidPeso molecular:144.58 kDaAbrilumab
CAS:Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.Pureza:98.5% (SDS-PAGE); 99% (SEC-HPLC) - 98.5% (SDS-PAGE); 99% (SEC-HPLC)Cor e Forma:Transparent LiquidPeso molecular:143.80 kDaEfalizumab
CAS:Efalizumab: humanized monoclonal antibody CD11a; modulates T cell activation/adhesion; for plaque psoriasis, psoriatic arthritis research.Pureza:SDS-PAGE:95% SEC-HPLC:98.77%Cor e Forma:Transparent LiquidPeso molecular:146.14 kDaOrbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFórmula:C19H24F3N5O6Pureza:97.21% - 99.23%Cor e Forma:SolidPeso molecular:475.42Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Fórmula:C26H34F6N4O8Pureza:98.48%Cor e Forma:SolidPeso molecular:644.56GRGDSPK TFA
GRGDSPK TFA is an RGD peptide, competitive inhibitor of integrin-fibronectin, used to research integrins in bone dynamics.Fórmula:C30H50F3N11O13Cor e Forma:SolidPeso molecular:829.78LDV FITC
CAS:fluorescent ligand that binds to the α4β1 integrin (VLA-4)Fórmula:C69H81N11O17SPureza:98%Cor e Forma:SolidPeso molecular:1368.53MINT1526A
MINT1526A (RG-7594) is a humanized IgG1 monoclonal antibody inhibitor targeting α5β1 integrin, exhibiting significant anti-angiogenic activity. This compound is applicable in cancer research.KGDS
CAS:KGDS is a synthetic peptide that targets the integrin GPIIb-IIIa on the membrane of activated human platelets, with the amino acid sequence Lys-Gly-Asp-Ser [1].Fórmula:C15H27N5O8Cor e Forma:SolidPeso molecular:405.4αvβ6-BP
αvβ6-BP is a selective αvβ6-binding peptide, useful for research in molecular imaging.Fórmula:C93H164N34O27Peso molecular:2189.25052Lys-Gln-Ala-Gly-Asp-Val
CAS:KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.Fórmula:C25H44N8O10Cor e Forma:SolidPeso molecular:616.66LXY3
CAS:LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.Fórmula:C32H43N11O15S2Cor e Forma:SolidPeso molecular:885.88STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.12 kDaLT25
CAS:LT25 (compound 17) acts as an agonist for the α5β1 integrin, exhibiting an EC50 value of 9.9 nM.Fórmula:C15H17N3O5Cor e Forma:SolidPeso molecular:319.31BGC0222
BGC0222 is a novel Irinotecan prodrug. As a PEG-cRGD conjugated derivative of Irinotecan, BGC0222 enables the slow and steady release of Irinotecan. It binds to the αVβ3 target with an IC50 of 4.25 μM and has an IC50 of 58.7 μM for αVβ5. BGC0222 can induce angiogenesis and demonstrates significant antitumor activity in various tumors.Fórmula:C1241H2276N64O552Cor e Forma:SolidPeso molecular:26927.36Integrin Binding Peptide
CAS:Integrin Binding Peptide, derived from fibronectin, holds the potential as an essential component for preparing PEG hydrogels.Fórmula:C42H63N15O16SCor e Forma:SolidPeso molecular:1066.12RTDLDSLRTYTL
CAS:RTDLDSLRTYTL is a high-affinity and specific inhibitor of Alpha (v) beta (6) integrin (avb6). By binding to the avb6 integrin, this peptide sequence activates T cell cytotoxicity and cytokine production, such as interferon-γ. Through the design of chimeric T cell antigen receptors (CAR), RTDLDSLRTYTL enables T cells to be redirected, allowing them to specifically recognize and attack tumor cells. It is used in research for cancer immunotherapy and the development of targeted drugs.Fórmula:C62H104N18O22Cor e Forma:SolidPeso molecular:1453.60HSDVHK-NH2 TFA
HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [Fórmula:C32H49F3N12O11Cor e Forma:SolidPeso molecular:834.8Echistatin TFA
Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.Cor e Forma:Odour SolidOrbofiban acetate
CAS:Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administeredFórmula:C19H27N5O6Cor e Forma:SolidPeso molecular:421.45R-BC154 acetate
R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.Fórmula:C56H65N9O14S3Cor e Forma:SolidPeso molecular:1184.36c(phg-isoDGR-(NMe)k) TFA
C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].Fórmula:C29H42F3N9O9Cor e Forma:SolidPeso molecular:717.69Bimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Fórmula:C46H54O16Pureza:98%Cor e Forma:SolidPeso molecular:862.91TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Fórmula:C37H50F2N12O13Cor e Forma:SolidPeso molecular:908.86α2β1 Integrin Ligand Peptide TFA
α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is aFórmula:C16H23F3N4O11Pureza:98%Cor e Forma:SolidPeso molecular:504.37AFM15
AFM15 is a humanized monoclonal antibody inhibitor that targets CD3E. It is useful for researching metabolic and immune system disorders, including type 1 diabetes and inflammatory bowel disease (IBD).Cor e Forma:Odour LiquidhuATN-658
huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.Cor e Forma:Odour LiquidAB-3PRGD2
CAS:AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.Fórmula:C137H215IN30O45SCor e Forma:SolidPeso molecular:3161.32Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SCor e Forma:SolidPeso molecular:655.727Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a mAb targeting CD147 used to study the inhibition mechanisms of viral infection by blocking receptor binding to viralCor e Forma:Odour LiquidMumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.Fórmula:C12H12O9Cor e Forma:SolidPeso molecular:300.22EMD527040
CAS:EMD527040 is a potent αvβ6 antagonist with antifibrotic effects, used in carcinoma and liver fibrosis research.Fórmula:C29H32Cl2N4O5Cor e Forma:SolidPeso molecular:587.5BIO5192 hydrate
BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.Cor e Forma:SolidαVβ8-IN-1
CAS:αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Fórmula:C25H32ClN5O4Cor e Forma:White SolidPeso molecular:502.01Fradafiban hydrochloride
Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.Fórmula:C20H22ClN3O4Cor e Forma:SolidPeso molecular:403.86
