Integrinas
Os inibidores de integrinas têm como alvo as integrinas, uma família de receptores de superfície celular que desempenham um papel crucial na adesão celular, migração e transdução de sinais. As integrinas estão envolvidas na regulação do ciclo celular, particularmente em processos como divisão e diferenciação celular. Inibir integrinas pode interromper esses processos, levando à parada do ciclo celular e apoptose, tornando esses inibidores valiosos na pesquisa do câncer e no estudo da metástase. Na CymitQuimica, oferecemos uma ampla gama de inibidores de integrinas de alta qualidade para apoiar sua pesquisa em regulação do ciclo celular, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 275 produtos para "Integrinas".
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AFM15
AFM15 is a humanized monoclonal antibody inhibitor that targets CD3E. It is useful for researching metabolic and immune system disorders, including type 1 diabetes and inflammatory bowel disease (IBD).Cor e Forma:Odour LiquidMLN2201
MLN2201 is a humanized monoclonal antibody inhibitor that targets Integrinβ2. It can inhibit reperfusion injury following a stroke and is applicable for researching inflammatory conditions such as ischemic stroke.Cor e Forma:Odour LiquidNelvutamig
CAS:Nelvutamig is a humanized immunoglobulin antibody (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3) designed to target ENPP3/CD203c and CD3E. The corresponding isotype control is Human immunoglobulin (H-gamma1_L-kappa)_scFvkh-G1(h-CH2-CH3).Cor e Forma:LiquidOrbofiban acetate
CAS:Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administeredFórmula:C19H27N5O6Cor e Forma:SolidPeso molecular:421.45huATN-658
huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.Cor e Forma:Odour Liquidc(phg-isoDGR-(NMe)k) TFA
C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].Fórmula:C29H42F3N9O9Cor e Forma:SolidPeso molecular:717.69LT25
CAS:LT25 (compound 17) acts as an agonist for the α5β1 integrin, exhibiting an EC50 value of 9.9 nM.Fórmula:C15H17N3O5Cor e Forma:SolidPeso molecular:319.31RTDLDSLRTYTL
CAS:RTDLDSLRTYTL is a high-affinity and specific inhibitor of Alpha (v) beta (6) integrin (avb6). By binding to the avb6 integrin, this peptide sequence activates T cell cytotoxicity and cytokine production, such as interferon-γ. Through the design of chimeric T cell antigen receptors (CAR), RTDLDSLRTYTL enables T cells to be redirected, allowing them to specifically recognize and attack tumor cells. It is used in research for cancer immunotherapy and the development of targeted drugs.Fórmula:C62H104N18O22Cor e Forma:SolidPeso molecular:1453.60LXY3
CAS:LXY3 (LXY2) is a VLA-3 blocking peptide that inhibits the interaction of neutrophil surface integrin α3β1 (VLA-3) with laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is employed to block the neutrophil-mediated release of nanoparticles from the perivascular pool into the tumor stroma and is frequently used for targeted imaging in breast cancer.Fórmula:C32H43N11O15S2Cor e Forma:SolidPeso molecular:885.88BGC0222
BGC0222 is a novel Irinotecan prodrug. As a PEG-cRGD conjugated derivative of Irinotecan, BGC0222 enables the slow and steady release of Irinotecan. It binds to the αVβ3 target with an IC50 of 4.25 μM and has an IC50 of 58.7 μM for αVβ5. BGC0222 can induce angiogenesis and demonstrates significant antitumor activity in various tumors.Fórmula:C1241H2276N64O552Cor e Forma:SolidPeso molecular:26927.36STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Pureza:97.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 97.3% (SDS-PAGE); 97.5% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:145.12 kDaGantofiban
CAS:Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.Fórmula:C21H29N5O6Pureza:99.57%Cor e Forma:SolidPeso molecular:447.48YRGDS Fibronectin Fragment
CAS:This is a fibronectin fragment, an adhesion peptide that displays strong binding affinity to thrombin-stimulated platelets. It is RGD consisting of sequence.Fórmula:C24H36N8O10Pureza:98%Cor e Forma:SolidPeso molecular:596.59αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Fórmula:C25H30F3N3O3Cor e Forma:SolidPeso molecular:477.52ASP5094
ASP5094 is a humanized anti-integrin α9 monoclonal antibody. It exhibits excellent safety and tolerability. ASP5094 can be utilized in the research of diseases such as rheumatoid arthritis.Cor e Forma:Odour LiquidGamgertamig
CAS:Gamgertamig is a humanized bispecific antibody of the IgG4 type that targets TNFRSF17 and CD3E.Cor e Forma:LiquidBRM/BRG1 ligand 3
CAS:BRM/BRG1 ligand 3 is a target protein ligand utilized in the synthesis of PROTAC BRM/BRG1 degrader-3.Fórmula:C19H24N6OCor e Forma:SolidPeso molecular:352.43Dentonin TFA
Dentonin TFA (AC-100 TFA) is a short peptide fragment derived from MEPE. It enhances osteogenesis by promoting the adhesion of osteoprogenitor cells and supports the survival of immature adherent cells. Dentonin TFA does not have a significant effect on mature osteoblasts and can be utilized in studies of phosphate homeostasis and bone metabolism.Fórmula:C109H161F3N30O44Peso molecular:2651.1235PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Fórmula:C17H12F3NO2Cor e Forma:SolidPeso molecular:319.278Bimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Fórmula:C46H54O16Pureza:98%Cor e Forma:SolidPeso molecular:862.91EMD527040 hydrochloride
EMD527040 (hydrochloride) is a potent and selective αvβ6 antagonist with antifibrotic properties. It is applicable in research related to liver cancer and hepatic fibrosis.Cor e Forma:Odour SolidG-Pen-GRGDSPCA TFA
G-Pen-GRGDSPCA TFA is an αvβ3 inhibitory RGD peptide. It inhibits neointimal hyperplasia and luminal narrowing following vascular injury and regulates the migration and proliferation of smooth muscle cells. This compound can be utilized in studies related to mechanisms of vascular injury repair.Cor e Forma:Odour SolidEchistatin TFA
Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.Cor e Forma:Odour SolidBimosiamose disodium
CAS:Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Fórmula:C46H52Na2O16Pureza:98%Cor e Forma:SolidPeso molecular:906.88TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Fórmula:C37H50F2N12O13Cor e Forma:SolidPeso molecular:908.86Batifiban
CAS:Batifiban, a glycoprotein IIb/IIIa antagonist, is used potentially for the treatment of coronary artery disease.Fórmula:C34H47N11O9S2Cor e Forma:SolidPeso molecular:817.93HSDVHK-NH2
CAS:Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.Fórmula:C30H48N12O9Pureza:98%Cor e Forma:SolidPeso molecular:720.78P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Fórmula:C53H81N13O11Pureza:98.39%Cor e Forma:SolidPeso molecular:1076.29c(avb6)-DOTA TFA
c(avb6)-DOTA TFA is a conjugate formed by the coupling of a selective αvβ6 integrin cyclic peptide and a DPTA chelating agent. The Lu (III) complex of c(avb6)-DOTA TFA exhibits considerable affinity for αvβ6 integrin (IC50=0.8 nM), making it suitable for tumor diagnostics.Fórmula:C69H102F3N17O20Cor e Forma:SolidPeso molecular:1546.65Emaretamig
CAS:Emaretamig is a humanized IgG1κ monoclonal antibody inhibitor that targets CLDN18 and CD3E. Abdakibart is applicable for cancer research related to gastric and pancreatic cancers.Cor e Forma:LiquidGly-Arg-Gly-Asp-Ser
CAS:Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.Fórmula:C17H30N8O9Pureza:98%Cor e Forma:SolidPeso molecular:490.47R-BC154 acetate
R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.Fórmula:C56H65N9O14S3Cor e Forma:SolidPeso molecular:1184.36AB-3PRGD2
CAS:AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.Fórmula:C137H215IN30O45SCor e Forma:SolidPeso molecular:3161.32α2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFórmula:C14H22N4O9Pureza:98%Cor e Forma:SolidPeso molecular:390.35Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SCor e Forma:SolidPeso molecular:655.727EMD527040
CAS:EMD527040 is a potent αvβ6 antagonist with antifibrotic effects, used in carcinoma and liver fibrosis research.Fórmula:C29H32Cl2N4O5Cor e Forma:SolidPeso molecular:587.5Lys-Gln-Ala-Gly-Asp-Val
CAS:KQAGDV is a fibrinogen γ-chain cell adhesion peptide, targeting α2bβ3 integrin, and binds SMCs.Fórmula:C25H44N8O10Cor e Forma:SolidPeso molecular:616.66Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a mAb targeting CD147 used to study the inhibition mechanisms of viral infection by blocking receptor binding to viralCor e Forma:Odour LiquidFradafiban hydrochloride
Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.Fórmula:C20H22ClN3O4Cor e Forma:SolidPeso molecular:403.86Mumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.Fórmula:C12H12O9Cor e Forma:SolidPeso molecular:300.22SMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Fórmula:C20H21NO5Pureza:98.29%Cor e Forma:SoildPeso molecular:355.38BIO5192 hydrate
BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.Cor e Forma:SolidLamifiban trifluoroacetate
CAS:Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa).Fórmula:C26H29F3N4O8Cor e Forma:SolidPeso molecular:582.533αvβ5 integrin-IN-1
CAS:αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.Fórmula:C25H28F3N3O3Cor e Forma:SolidPeso molecular:475.512LDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Fórmula:C48H70N10O12Pureza:98%Cor e Forma:SolidPeso molecular:979.13Echistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Fórmula:C217H341N71O74S9Pureza:98%Cor e Forma:SolidPeso molecular:5417.1Anti-GPRC5D Antibody
Anti-GPRC5D Antibody is a humanized IgG1 monoclonal antibody targeting GPRC5D. It serves as the antibody component of the ADC molecule LM-305.Cor e Forma:Odour Liquidα2β1 Integrin Ligand Peptide TFA
α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is aFórmula:C16H23F3N4O11Pureza:98%Cor e Forma:SolidPeso molecular:504.37Fibronectin CS1 Peptide
CAS:Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.Fórmula:C38H64N8O15Pureza:98%Cor e Forma:SolidPeso molecular:872.96SAN-300
SAN-300 is a human-derived IgG1 monoclonal antibody (mAb) that targets ITGA1/VLA-1. It is utilized in the research of rheumatoid arthritis.Cor e Forma:Odour Liquid
