Integrinas
Os inibidores de integrinas têm como alvo as integrinas, uma família de receptores de superfície celular que desempenham um papel crucial na adesão celular, migração e transdução de sinais. As integrinas estão envolvidas na regulação do ciclo celular, particularmente em processos como divisão e diferenciação celular. Inibir integrinas pode interromper esses processos, levando à parada do ciclo celular e apoptose, tornando esses inibidores valiosos na pesquisa do câncer e no estudo da metástase. Na CymitQuimica, oferecemos uma ampla gama de inibidores de integrinas de alta qualidade para apoiar sua pesquisa em regulação do ciclo celular, biologia do câncer e desenvolvimento terapêutico.
Foram encontrados 224 produtos de "Integrinas"
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Vibecotamab
CAS:<p>Vibecotamab, a bispecific antibody, targets CD123/CD3 for T-cell killing of tumors, promising for acute myeloid leukemia.</p>Cor e Forma:LiquidObrindatamab
CAS:<p>Obrindatamab: a humanized bispecific antibody targeting B7-H3/CD3, enhances CTL-mediated cancer cell killing.</p>Cor e Forma:LiquidPacanalotamab
CAS:<p>Pacanalotamab (AMG 420/BI-836909), a BiTE, directs T-cells to BCMA+ MM cells, causing lysis.</p>Cor e Forma:LiquidOS-2966
<p>OS-2966 is a humanised de-immunised monoclonal antibody that target Integrin b1/ITGB1/CD29, malignant gliomas, glioblastomas, and astrocytomas.</p>Pureza:95%Cor e Forma:Odour LiquidAnti-Mouse CD3ε Antibody (145-2C11)
<p>Anti-Mouse CD3ε Antibody (145-2C11) is an antibody inhibitor targeting CD3ε in Armenian hamsters, in TCR formation and in T lymphocyte activation</p>Pureza:99%Cor e Forma:Odour LiquidGresonitamab
CAS:<p>Gresonitamab (AMG 910) is an HLE BiTE antibody targeting CD3+ T cells and CLDN18.2+ tumors, for adenocarcinoma research.</p>Cor e Forma:LiquidSB273005
CAS:<p>SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.</p>Fórmula:C22H24F3N3O4Pureza:99.58%Cor e Forma:SolidPeso molecular:451.44Tirofiban
CAS:<p>Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.</p>Fórmula:C22H36N2O5SPureza:99.83%Cor e Forma:SolidPeso molecular:440.6GR 144053 trihydrochloride
CAS:<p>platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonist</p>Fórmula:C18H30Cl3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:454.82Sibrafiban
CAS:<p>Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.</p>Fórmula:C20H28N4O6Cor e Forma:SolidPeso molecular:420.46UR-3216
CAS:<p>UR-3216 is a prodrug, selectively antagonizing GPIIb/IIIa receptors orally, with its active form, UR-2992, binding tightly to platelets.</p>Fórmula:C27H29N7O7Pureza:98%Cor e Forma:SolidPeso molecular:563.56L 703014
CAS:<p>L 703014 is an antagonist of the fibrinogen receptor.</p>Fórmula:C24H34N4O4Pureza:98%Cor e Forma:SolidPeso molecular:442.55Balamapimod
CAS:<p>Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.</p>Fórmula:C30H32ClN7OSPureza:98%Cor e Forma:SolidPeso molecular:574.14BMS-587101
CAS:<p>BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.</p>Fórmula:C26H20Cl2N4O4SCor e Forma:SolidPeso molecular:555.43BMS-688521
CAS:<p>BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.</p>Fórmula:C26H19Cl2N5O4Pureza:98.87%Cor e Forma:SolidPeso molecular:536.37MK-0668
CAS:<p>MK-0668 is a very potent and orally active very late antigen-4 antagonist.</p>Fórmula:C31H30Cl2N6O6SCor e Forma:SolidPeso molecular:685.58NSC47924
CAS:<p>NSC47924 is a laminin receptor (LR) inhibitor.</p>Fórmula:C18H17NO2Pureza:98%Cor e Forma:SolidPeso molecular:279.33Zalunfiban
CAS:<p>RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.</p>Fórmula:C16H18N8O2SCor e Forma:SolidPeso molecular:386.43TCS 2314
CAS:<p>TCS 2314 is an orally active and selective very late antigen-4 antagonist (IC50: 4.4 nM).</p>Fórmula:C28H34N4O6Pureza:98%Cor e Forma:SolidPeso molecular:522.59Chrysotobibenzyl
CAS:<p>Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.</p>Fórmula:C19H24O5Cor e Forma:SolidPeso molecular:332.39αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
<p>αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).</p>Fórmula:C28H35F3N6O8SPureza:98%Cor e Forma:SolidPeso molecular:672.67Zaurategrast ethyl ester sulfate
CAS:<p>Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.</p>Fórmula:C56H60Br2N8O10SPureza:98%Cor e Forma:SolidPeso molecular:1197.01RUC-1
CAS:<p>RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.</p>Fórmula:C11H15N5OSPureza:98%Cor e Forma:SolidPeso molecular:265.33Zaurategrast ethyl ester
CAS:<p>Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.</p>Fórmula:C28H29BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:549.46IMB-10
CAS:<p>IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.</p>Fórmula:C19H15NOS2Cor e Forma:SolidPeso molecular:337.46Ro 43-5054
CAS:<p>Ro 43-5054 is a small molecular, noncyclic peptidomimetic inhibitor.</p>Fórmula:C24H27N5O7Pureza:98%Cor e Forma:SolidPeso molecular:497.5BOP sodium
CAS:<p>BOP sodium salt is an inhibitor of alpha9beta1 and alpha4beta1 integrin.</p>Fórmula:C25H29N3NaO7SCor e Forma:SolidPeso molecular:538.57GSK-3008348
CAS:<p>GSK-3008348 is an antagonist of integrin alpha(v)beta6.</p>Fórmula:C29H37N5O2Pureza:99.547%Cor e Forma:SolidPeso molecular:487.64Valategrast
CAS:<p>Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.</p>Fórmula:C30H32Cl3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:604.95Valategrast hydrochloride
CAS:<p>Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.</p>Fórmula:C30H33Cl4N3O4Pureza:98%Cor e Forma:SolidPeso molecular:641.41CLT-28643
CAS:<p>CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.</p>Fórmula:C19H17N3O4Pureza:99.89%Cor e Forma:SolidPeso molecular:351.36Integrin-IN-2
CAS:<p>Integrin-IN-2, an oral αv integrin blocker, enhances αvβ6/3/5/8 affinities with pIC50s: 7.8/8.4/8.4/7.4.</p>Fórmula:C27H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:458.55XVA143
CAS:<p>XVA143, an α/β I-like allosteric antagonist, blocks LFA-1 adhesion and combats P. gingivalis in mice, preventing bone loss.</p>Fórmula:C25H21Cl2N3O8Cor e Forma:SolidPeso molecular:562.36Integrin modulator 1
CAS:<p>Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.</p>Fórmula:C13H14N2O4Pureza:99.61%Cor e Forma:SolidPeso molecular:262.26Firategrast
CAS:<p>Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous</p>Fórmula:C27H27F2NO6Pureza:99.16%Cor e Forma:SolidPeso molecular:499.5Elarofiban
CAS:<p>Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.</p>Fórmula:C22H32N4O4Pureza:98.76%Cor e Forma:SolidPeso molecular:416.513-Hydroxyxanthone
CAS:<p>3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein</p>Fórmula:C13H8O3Pureza:98%Cor e Forma:SolidPeso molecular:212.2ICAM-1-IN-1
CAS:<p>ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.</p>Fórmula:C15H11BrN2O2SPureza:99.67%Cor e Forma:SolidPeso molecular:363.23BI-1950
CAS:<p>BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.</p>Fórmula:C32H26Cl2FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:646.5Teclistamab
CAS:<p>Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.</p>Pureza:95%Cor e Forma:LiquidSynstatin (92-119)
CAS:<p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>Fórmula:C133H207N35O46Pureza:98%Cor e Forma:SolidPeso molecular:3032.27TAK 029
CAS:<p>TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.</p>Fórmula:C19H23N5O7Cor e Forma:SolidPeso molecular:433.42αvβ6 integrin inhibitor 2
CAS:<p>αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM.</p>Fórmula:C21H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:386.49Lotrafiban
CAS:<p>Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.</p>Fórmula:C23H32N4O4Cor e Forma:SolidPeso molecular:428.52JNJ-26076713
CAS:<p>JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.</p>Fórmula:C29H38N4O3Pureza:98%Cor e Forma:SolidPeso molecular:490.64SB-267268
CAS:<p>SB-267268: αvβ3 inhibitor (IC50: 0.68 nM human, 0.29 nM mouse), blocks αvβ3/αvβ5 integrins (Ki: 0.9 nM human, 0.5 nM monkey αvβ3, 0.7 nM human αvβ5).</p>Fórmula:C22H24F3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:451.44Zaurategrast
CAS:<p>Zaurategrast is an effective and oral-effective inhibitor of the α4-integrin.</p>Fórmula:C26H25BrN4O3Pureza:98%Cor e Forma:SolidPeso molecular:521.41Solitomab
CAS:<p>Solitomab (AMG 110) is a bispecific antibody targeting CD3 and EpCAM, used in uterine/ovarian carcinosarcoma research.</p>Cor e Forma:LiquidCarotegrast
CAS:<p>Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.</p>Fórmula:C27H24Cl2N4O5Cor e Forma:SolidPeso molecular:555.41Tirofiban HCl
CAS:<p>Tirofiban HCl is an antagonist of platelet glycoprotein-IIb/IIIa receptor.</p>Fórmula:C22H37ClN2O5SPureza:98%Cor e Forma:SolidPeso molecular:477.06
