LIM Quinase
Os inibidores de quinase LIM têm como alvo as quinases LIM, uma família de enzimas envolvidas na regulação do citoesqueleto de actina e na progressão do ciclo celular. As quinases LIM fosforilam e inativam a cofilina, uma proteína que desagrega filamentos de actina, controlando assim a forma, motilidade e divisão celular. A inibição de quinases LIM pode afetar esses processos, levando a alterações na dinâmica do ciclo celular e potencial apoptose. Os inibidores de quinase LIM são ferramentas importantes na pesquisa do câncer e no estudo da motilidade e invasão celular. Na CymitQuimica, oferecemos uma seleção de inibidores de quinase LIM de alta qualidade para apoiar sua pesquisa em sinalização celular, dinâmica do citoesqueleto e oncologia.
Foram encontrados 19 produtos de "LIM Quinase"
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R-10015
CAS:R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Fórmula:C20H19ClN6O2Pureza:98.68%Cor e Forma:SolidPeso molecular:410.86Ref: TM-T12609
1mg52,00€5mg118,00€10mg180,00€25mg296,00€50mg393,00€100mg553,00€200mg752,00€1mL*10mM (DMSO)131,00€S3 Fragment
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinaseFórmula:C73H120N18O24S2Cor e Forma:SolidPeso molecular:1697.978β,9α-Dihydroxylindan-4(5),7(11)-dien-8α,12-olide
CAS:8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].Fórmula:C15H18O4Cor e Forma:SolidPeso molecular:262.3BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H12Cl2F2N4OSPureza:99.31% - 99.81%Cor e Forma:SolidPeso molecular:429.27T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Fórmula:C19H14F3N3O3Pureza:98.39% - 99.57%Cor e Forma:SolidPeso molecular:389.33BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H14Cl2F2N4OSPureza:98.01% - 99.88%Cor e Forma:SolidPeso molecular:431.29Ref: TM-T4598
1mg43,00€2mg55,00€5mg84,00€10mg123,00€25mg198,00€50mg298,00€100mg444,00€1mL*10mM (DMSO)92,00€LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Fórmula:C20H21BrN8Pureza:99.165%Cor e Forma:SolidPeso molecular:453.34TH-263
CAS:TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Fórmula:C21H20N2O3SPureza:99.54%Cor e Forma:SolidPeso molecular:380.46Ref: TM-T19578
2mg35,00€5mg52,00€10mg80,00€25mg144,00€50mg202,00€100mg298,00€200mg442,00€1mL*10mM (DMSO)57,00€TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Fórmula:C24H26N2O3SPureza:98.23%Cor e Forma:SolidPeso molecular:422.54TH470
CAS:TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Fórmula:C30H31N5O5S2Cor e Forma:SolidPeso molecular:605.73LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Fórmula:C23H23N7O2SCor e Forma:SolidPeso molecular:461.54CRT-0105446
CAS:CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C20H18F3N3O2SPureza:98%Cor e Forma:SolidPeso molecular:421.44SR7826
CAS:SR7826 is a selective LIMK inhibitor.Fórmula:C22H21N5O2Pureza:98%Cor e Forma:SolidPeso molecular:387.43LIMK-IN-14
CAS:LIMK-IN-14 is an effective and selective inhibitor of LIMK.Fórmula:C22H27N7O3Pureza:98%Cor e Forma:SolidPeso molecular:437.49CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Cor e Forma:SolidPeso molecular:393.89Ref: TM-T23917
1mg65,00€5mg140,00€10mg216,00€25mg439,00€50mg707,00€100mg1.130,00€1mL*10mM (DMSO)156,00€LX7101 hydrochloride
CAS:LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Fórmula:C23H29N7O3HClCor e Forma:SolidPeso molecular:488LIMK-IN-2
CAS:LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].Fórmula:C28H27N5O2Cor e Forma:SolidPeso molecular:465.55LIMK1 inhibitor 1
CAS:LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.Fórmula:C12H15N3S2Cor e Forma:SolidPeso molecular:265.398LIMK1 inhibitor 2
CAS:LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.Fórmula:C10H11N3OSCor e Forma:SolidPeso molecular:221.279
