CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 501 produtos de "CDK"
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CDK12-IN-E9
CAS:<p>CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.</p>Fórmula:C24H30N6O2Cor e Forma:SolidPeso molecular:434.53AS2863619 free base
CAS:<p>AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.</p>Fórmula:C16H12N8OCor e Forma:SolidPeso molecular:332.32Cdc7-IN-4
CAS:<p>Cdc7-IN-4 is a potent inhibitor of Cdc7 kinase.</p>Fórmula:C22H24F3N5O4Pureza:98%Cor e Forma:SolidPeso molecular:479.45CLK1-IN-1
CAS:<p>CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).</p>Fórmula:C24H16FN5OCor e Forma:SolidPeso molecular:409.42THZ1-R
CAS:<p>THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.</p>Fórmula:C31H30ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:568.07CDK8/19-IN-51
CAS:<p>CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.</p>Fórmula:C23H22N6O2Pureza:98.65% - 99.62%Cor e Forma:SoildPeso molecular:414.46ARN22089
CAS:<p>ARN22089 is an oral active CDC42 GTPase interaction inhibitor that blocks tumour growth in BRAF mutant mouse melanoma models and PDXs in vivo.</p>Fórmula:C23H27N5Pureza:98.37%Cor e Forma:SolidPeso molecular:373.49NSC 625987
CAS:<p>Cyclin-dependent kinase (cdk) 4 inhibitor</p>Fórmula:C15H13NO2SPureza:98%Cor e Forma:SolidPeso molecular:271.33RP-106
CAS:<p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>Fórmula:C17H19N3OPureza:98%Cor e Forma:SolidPeso molecular:281.35CDK7-IN-16
CAS:<p>CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.</p>Fórmula:C19H21F3N6O2SCor e Forma:SolidPeso molecular:454.47Cdc7-IN-5
CAS:<p>Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.</p>Fórmula:C25H23N3O5Pureza:97.15%Cor e Forma:SolidPeso molecular:445.47CDK2-IN-13
CAS:<p>CDK2-IN-13: Potent CDK2 inhibitor, arrests cell cycle, induces apoptosis, IC50=12 µM, used in cancer research.</p>Fórmula:C13H12ClN5Cor e Forma:SoildPeso molecular:273.72CLK-IN-T3
CAS:<p>CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity.</p>Fórmula:C28H30N6O2Pureza:99.61%Cor e Forma:SolidPeso molecular:482.58BML-259
CAS:<p>BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.</p>Fórmula:C14H16N2OSPureza:99.84%Cor e Forma:SolidPeso molecular:260.35Ryuvidine
CAS:<p>Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response, and can be used to study breast cancer and erythroderma.</p>Fórmula:C15H12N2O2SPureza:98.6%Cor e Forma:SolidPeso molecular:284.33dCeMM2
CAS:<p>dCeMM2 degrades glue by promoting CDK12-cyclin K ubiquitination and degradation via CRL4B ligase interaction.</p>Fórmula:C16H11ClN6OSPureza:99.68%Cor e Forma:SolidPeso molecular:370.82(S)-Enitociclib
CAS:<p>(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.</p>Fórmula:C19H18F2N4O2SPureza:98.98%Cor e Forma:SolidPeso molecular:404.439-Isopropylolomoucine
CAS:<p>9-Isopropylolomoucine (N9-Isopropylolomoucine), a cell cycle protein-dependent kinase inhibitor, is a thiopurine.</p>Fórmula:C17H22N6OPureza:99.82%Cor e Forma:SolidPeso molecular:326.4PS423
CAS:<p>PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.</p>Fórmula:C25H23F3O9Pureza:98.81% - 99.26%Cor e Forma:SolidPeso molecular:524.44CDK4/6/1 Inhibitor
CAS:<p>CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).</p>Fórmula:C28H30F2N6Pureza:99.26% - 99.72%Cor e Forma:SolidPeso molecular:488.57
