CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 547 produtos de "CDK"
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LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Fórmula:C16H12FN5OPureza:99.87%Cor e Forma:SolidPeso molecular:309.3Ref: TM-T7810
1mg38,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg109,00€25mg212,00€50mg318,00€100mg477,00€200mg677,00€LDC4297 hydrochloride
CAS:LDC4297 hydrochloride is a selective and potent CDK7 inhibitor with broad-spectrum antiviral activity, useful for research on viral infections.Fórmula:C23H29ClN8OCor e Forma:SolidPeso molecular:468.987BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Fórmula:C16H10BrN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:356.17BS-181 dihydrochloride
CAS:BS-181 dihydrochloride: Potent CDK7 inhibitor (IC50: 21 nM), less effective on CDK2/5/9, no impact on CDK1/4/6, halts cancer cell growth, triggers apoptosis.Fórmula:C22H34Cl2N6Cor e Forma:SolidPeso molecular:453.46Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Cor e Forma:SolidPeso molecular:602.7NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Fórmula:C17H19Cl2N5O4SPureza:99.56% - 99.85%Cor e Forma:SolidPeso molecular:460.33Ref: TM-TQ0068
1mg46,00€5mg92,00€1mL*10mM (DMSO)94,00€10mg138,00€25mg255,00€50mg374,00€100mg533,00€200mg705,00€HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Fórmula:C15H15N5OS2Pureza:98.11%Cor e Forma:SolidPeso molecular:345.44Ref: TM-T9849
1mg43,00€2mg56,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg144,00€25mg319,00€50mg537,00€100mg767,00€500mg1.558,00€2-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Fórmula:C4H3ClN2Pureza:98.98% - 99.89%Cor e Forma:Clear Colorless To Yellowish LiquidPeso molecular:114.53RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:98% - 99.91%Cor e Forma:SolidPeso molecular:545.63SR-4835
CAS:SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Fórmula:C21H20Cl2N10OPureza:98.09% - >99.99%Cor e Forma:SolidPeso molecular:499.36LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.
Fórmula:C23H29ClN8OPureza:100%Cor e Forma:SolidPeso molecular:469.02LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Fórmula:C26H39N7O3Pureza:99.66%Cor e Forma:SolidPeso molecular:497.63FIT-039
CAS:FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Fórmula:C17H18FN3SPureza:98.61%Cor e Forma:SolidPeso molecular:315.41Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Fórmula:C16H11N3O2Pureza:98.34%Cor e Forma:SolidPeso molecular:277.28Ref: TM-T9138
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg236,00€50mg356,00€100mg532,00€200mg772,00€Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Fórmula:C21H31N7OPureza:99.75%Cor e Forma:SolidPeso molecular:397.52Ref: TM-TQ0053
1mg42,00€2mg55,00€1mL*10mM (DMSO)87,00€5mg88,00€10mg145,00€25mg260,00€50mg414,00€100mg583,00€MSC2530818
CAS:MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).Fórmula:C18H17ClN4OPureza:98.93%Cor e Forma:SolidPeso molecular:340.81Ref: TM-TQ0266
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg462,00€50mg692,00€100mg964,00€Senexin A
CAS:Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Fórmula:C17H14N4Pureza:99.74%Cor e Forma:SolidPeso molecular:274.32Ref: TM-T5673
1mg34,00€1mL*10mM (DMSO)71,00€5mg73,00€10mg94,00€25mg177,00€50mg323,00€100mg460,00€200mg622,00€Aminopurvalanol A
CAS:Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1Fórmula:C19H26ClN7OPureza:99.73%Cor e Forma:SolidPeso molecular:403.91Ref: TM-T22260
2mg39,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg173,00€50mg269,00€100mg389,00€200mg555,00€KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Cor e Forma:SolidPeso molecular:360.33Ref: TM-T9446
1mg90,00€2mg136,00€5mg222,00€1mL*10mM (DMSO)235,00€10mg358,00€25mg597,00€50mg850,00€100mg1.153,00€Amantadine
CAS:Amantadine (1-Aminoadamantane), an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release and blocks dopamine reuptake.Fórmula:C10H17NPureza:99.73% - 99.94%Cor e Forma:Hexakistetrahedral Crystals By Sublimation SolidPeso molecular:151.25ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Fórmula:C24H27N7OPureza:99.53% - 99.7%Cor e Forma:SolidPeso molecular:429.52Ribociclib
CAS:Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).Fórmula:C23H30N8OPureza:97.91% - >99.99%Cor e Forma:SolidPeso molecular:434.54Ref: TM-T6199
2mg43,00€5mg64,00€1mL*10mM (DMSO)69,00€10mg86,00€25mg97,00€50mg116,00€100mg168,00€500mg420,00€PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Fórmula:C12H11N3OPureza:99.49% - >99.99%Cor e Forma:SolidPeso molecular:213.24Ref: TM-T6206
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg64,00€25mg92,00€50mg138,00€100mg197,00€200mg295,00€Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFórmula:C15H10O5Pureza:97.93%Cor e Forma:SolidPeso molecular:270.24ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Fórmula:C19H22O7SPureza:98.27%Cor e Forma:SolidPeso molecular:394.44Ref: TM-T16391
1mg48,00€1mL*10mM (DMSO)60,00€5mg71,00€10mg100,00€25mg172,00€50mg268,00€100mg404,00€200mg570,00€Dalpiciclib
CAS:Dalpiciclib (SHR-6390) selectively inhibits CDK4/6 (IC50: 12.4/9.9 nM), is orally available, and impedes esophageal cancer growth.
Fórmula:C25H30N6O2Pureza:99.69%Cor e Forma:SolidPeso molecular:446.54LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Fórmula:C16H12FN5OCor e Forma:SolidPeso molecular:309.3SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Fórmula:C15H18BrN7Pureza:99.88%Cor e Forma:SolidPeso molecular:376.25Ref: TM-T3700
1mg50,00€2mg66,00€5mg90,00€1mL*10mM (DMSO)108,00€10mg146,00€25mg250,00€50mg403,00€100mg593,00€BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Fórmula:C16H17N5Pureza:90%Cor e Forma:SolidPeso molecular:279.34CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H14Cl3N3O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:358.67Ref: TM-T19913
1mg73,00€5mg128,00€1mL*10mM (DMSO)140,00€10mg185,00€25mg299,00€50mg405,00€100mg545,00€CC-671
CAS:CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Fórmula:C28H28N6O4Pureza:98.66% - 98.8%Cor e Forma:SolidPeso molecular:512.56Ref: TM-T4482
1mg50,00€5mg105,00€1mL*10mM (DMSO)120,00€10mg170,00€25mg340,00€50mg512,00€100mg733,00€500mg1.513,00€Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Fórmula:C32H44O8Pureza:98.88% - 99.87%Cor e Forma:SolidPeso molecular:556.69Ref: TM-T5S1467
1mg56,00€5mg109,00€1mL*10mM (DMSO)133,00€10mg168,00€25mg284,00€50mg423,00€100mg610,00€AG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Fórmula:C16H12N2O3Pureza:98.69%Cor e Forma:SolidPeso molecular:280.28BGG463
CAS:BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 μM, 0.09 μM and 0.590 μM, respectively.Fórmula:C30H29F3N6O3Pureza:98.21% - >99.99%Cor e Forma:SolidPeso molecular:578.58Ref: TM-T4618
1mg58,00€2mg82,00€5mg113,00€1mL*10mM (DMSO)145,00€10mg178,00€25mg333,00€50mg477,00€100mg692,00€Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Fórmula:C55H103N15O14Pureza:96.21%Cor e Forma:SolidPeso molecular:1198.5SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Cor e Forma:SolidPeso molecular:376.25MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Fórmula:C21H19N3O2SPureza:98.80%Cor e Forma:SolidPeso molecular:377.46Ref: TM-T22106
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg161,00€50mg245,00€100mg363,00€200mg515,00€Purvalanol A
CAS:Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.Fórmula:C19H25ClN6OPureza:98.13% - 99.68%Cor e Forma:PowderPeso molecular:388.89NU2058
CAS:NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Fórmula:C12H17N5OPureza:99.34% - 99.92%Cor e Forma:SolidPeso molecular:247.3Ref: TM-T3186
10mg42,00€1mL*10mM (DMSO)47,00€25mg78,00€50mg106,00€100mg160,00€200mg230,00€500mg378,00€SNS-032
CAS:SNS-032 (BMS-387032) is a selective inhibitor of CDK2 and is 10- and 20-fold selective over CDK1/CDK4. SNS-032 is sensitive to CDK7/9, and no effect on CDK6.Fórmula:C17H24N4O2S2Pureza:98.27% - 99.91%Cor e Forma:SolidPeso molecular:380.53Ref: TM-T6049
5mg48,00€1mL*10mM (DMSO)50,00€10mg63,00€25mg92,00€50mg124,00€100mg202,00€200mg299,00€500mg504,00€TC11
CAS:TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosisFórmula:C20H22N2O2Pureza:97.86%Cor e Forma:SolidPeso molecular:322.4LY2857785
CAS:LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).Fórmula:C26H36N6OPureza:99.68%Cor e Forma:Solid PowderPeso molecular:448.6Ref: TM-TQ0060
1mg50,00€2mg71,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg170,00€25mg334,00€50mg537,00€100mg863,00€PF-562271 hydrochloride
CAS:PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.Fórmula:C21H20F3N7O3SHClPureza:97.08%Cor e Forma:SolidPeso molecular:543.95Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Fórmula:C25H31ClN6O2Cor e Forma:SolidPeso molecular:483.01SEL120-34A HCl
CAS:SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFórmula:C15H19Br2ClN4Pureza:98.13% - 98.47%Cor e Forma:SolidPeso molecular:450.6AZD-5597
CAS:AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent
Fórmula:C23H28FN7OPureza:98.01%Cor e Forma:SolidPeso molecular:437.51AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Fórmula:C16H14Cl2N8OPureza:>99.99%Cor e Forma:SolidPeso molecular:405.24Ref: TM-T8378
1mg124,00€2mg170,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€6-(Dimethylamino)purine
CAS:6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitorFórmula:C7H9N5Pureza:99.01% - 99.77%Cor e Forma:SolidPeso molecular:163.18LDC000067
CAS:LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.Fórmula:C18H18N4O3SPureza:98.08% - 99.07%Cor e Forma:SolidPeso molecular:370.43AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Fórmula:C18H18Cl2F3N5O4Cor e Forma:SolidPeso molecular:496.27
