CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 547 produtos de "CDK"
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LY3405105
CAS:LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-Fórmula:C26H39N7O3Pureza:99.66%Cor e Forma:SolidPeso molecular:497.63NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Fórmula:C16H19ClN6OPureza:98% - 99.34%Cor e Forma:SolidPeso molecular:346.81PF-562271 besylate
CAS:PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Fórmula:C21H20F3N7O3S·C6H6O3SPureza:97.65% - 99.01%Cor e Forma:SolidPeso molecular:665.66Ref: TM-T6177
1mg35,00€5mg74,00€1mL*10mM (DMSO)89,00€10mg94,00€25mg138,00€50mg198,00€100mg296,00€200mg427,00€AT7519 Hydrochloride
CAS:AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.Fórmula:C16H18Cl3N5O2Pureza:99.66% - 99.9%Cor e Forma:SolidPeso molecular:418.71TC11
CAS:TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosisFórmula:C20H22N2O2Pureza:97.86%Cor e Forma:SolidPeso molecular:322.4HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Fórmula:C15H15N5OS2Pureza:98.11%Cor e Forma:SolidPeso molecular:345.44Ref: TM-T9849
1mg43,00€2mg56,00€1mL*10mM (DMSO)90,00€5mg93,00€10mg144,00€25mg319,00€50mg537,00€100mg767,00€500mg1.558,00€BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Fórmula:C18H17F2N3O2Pureza:99.25% - 99.57%Cor e Forma:SolidPeso molecular:345.34Ref: TM-T2679
1mg34,00€5mg71,00€1mL*10mM (DMSO)78,00€10mg110,00€25mg210,00€50mg318,00€100mg455,00€200mg617,00€LDC4297 hydrochloride
CAS:LDC4297 hydrochloride is a selective and potent CDK7 inhibitor with broad-spectrum antiviral activity, useful for research on viral infections.Fórmula:C23H29ClN8OCor e Forma:SolidPeso molecular:468.98KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Cor e Forma:SolidPeso molecular:360.33Ref: TM-T9446
1mg90,00€2mg136,00€5mg222,00€1mL*10mM (DMSO)235,00€10mg358,00€25mg597,00€50mg850,00€100mg1.153,00€CK7
CAS:CK7, a Cdk2/9 inhibitor, is instrumental in the synthesis of Nek1 inhibitors BSc5231 and BSc5367.Fórmula:C14H12N6O2SPureza:99.54%Cor e Forma:SolidPeso molecular:328.35Ref: TM-T9615
1mg50,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg177,00€25mg356,00€50mg557,00€100mg858,00€200mg1.153,00€Voruciclib
CAS:Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Fórmula:C22H19ClF3NO5Pureza:99.89% - 99.99%Cor e Forma:SolidPeso molecular:469.847BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Fórmula:C16H10BrN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:356.17Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Fórmula:C32H44O8Pureza:98.88% - 99.87%Cor e Forma:SolidPeso molecular:556.69Ref: TM-T5S1467
1mg56,00€5mg109,00€1mL*10mM (DMSO)133,00€10mg168,00€25mg284,00€50mg423,00€100mg610,00€Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Cor e Forma:SolidPeso molecular:602.7MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Fórmula:C21H19N3O2SPureza:98.80%Cor e Forma:SolidPeso molecular:377.46Ref: TM-T22106
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg161,00€50mg245,00€100mg363,00€200mg515,00€LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Fórmula:C16H12FN5OPureza:99.87%Cor e Forma:SolidPeso molecular:309.3Ref: TM-T7810
1mg38,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg109,00€25mg212,00€50mg318,00€100mg477,00€200mg677,00€NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Fórmula:C17H19Cl2N5O4SPureza:99.56% - 99.85%Cor e Forma:SolidPeso molecular:460.33Ref: TM-TQ0068
1mg46,00€5mg92,00€1mL*10mM (DMSO)94,00€10mg138,00€25mg255,00€50mg374,00€100mg533,00€200mg705,00€SNS-032
CAS:SNS-032 (BMS-387032) is a selective inhibitor of CDK2 and is 10- and 20-fold selective over CDK1/CDK4. SNS-032 is sensitive to CDK7/9, and no effect on CDK6.Fórmula:C17H24N4O2S2Pureza:98.27% - 99.91%Cor e Forma:SolidPeso molecular:380.53Ref: TM-T6049
5mg48,00€1mL*10mM (DMSO)50,00€10mg63,00€25mg92,00€50mg124,00€100mg202,00€200mg299,00€500mg504,00€Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.Fórmula:C16H11N3O2Pureza:98.34%Cor e Forma:SolidPeso molecular:277.28Ref: TM-T9138
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg120,00€25mg236,00€50mg356,00€100mg532,00€200mg772,00€Aminopurvalanol A
CAS:Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1Fórmula:C19H26ClN7OPureza:99.73%Cor e Forma:SolidPeso molecular:403.91Ref: TM-T22260
2mg39,00€5mg60,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg173,00€50mg269,00€100mg389,00€200mg555,00€1-NM-PP1
CAS:1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.Fórmula:C20H21N5Pureza:98% - 98.93%Cor e Forma:White Cyrstalline SolidPeso molecular:331.41Ref: TM-T2153
1mg48,00€2mg63,00€5mg84,00€1mL*10mM (DMSO)90,00€10mg132,00€25mg271,00€50mg505,00€100mg668,00€Dinaciclib
CAS:Dinaciclib (SCH 727965) is a CDK inhibitor that selectively inhibits CDK1, CDK2, CDK5, and CDK9 (IC50 = 3/1/1/4 nM).Fórmula:C21H28N6O2Pureza:98.21% - 99.75%Cor e Forma:SolidPeso molecular:396.49LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Fórmula:C16H12FN5OCor e Forma:SolidPeso molecular:309.3Ribociclib
CAS:Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).Fórmula:C23H30N8OPureza:97.91% - >99.99%Cor e Forma:SolidPeso molecular:434.54Ref: TM-T6199
2mg43,00€5mg64,00€1mL*10mM (DMSO)69,00€10mg86,00€25mg97,00€50mg116,00€100mg168,00€500mg420,00€NU2058
CAS:NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Fórmula:C12H17N5OPureza:99.34% - 99.92%Cor e Forma:SolidPeso molecular:247.3Ref: TM-T3186
10mg42,00€1mL*10mM (DMSO)47,00€25mg78,00€50mg106,00€100mg160,00€200mg230,00€500mg378,00€JSH-150
CAS:JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).Fórmula:C24H33ClN6O2SPureza:99.96% - 99.96%Cor e Forma:SolidPeso molecular:505.08ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Fórmula:C24H27N7OPureza:99.53% - 99.7%Cor e Forma:SolidPeso molecular:429.52FIT-039
CAS:FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).Fórmula:C17H18FN3SPureza:98.61%Cor e Forma:SolidPeso molecular:315.41Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Cor e Forma:SolidPeso molecular:335.33OTS964 hydrochloride
CAS:OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.Fórmula:C23H24N2O2S·HClPureza:96.5% - 98.03%Cor e Forma:SolidPeso molecular:428.97Ref: TM-T4135
1mg43,00€2mg56,00€5mg88,00€1mL*10mM (DMSO)92,00€10mg117,00€25mg187,00€50mg333,00€100mg495,00€AG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Fórmula:C16H12N2O3Pureza:98.69%Cor e Forma:SolidPeso molecular:280.28BSJ-03-123
CAS:BSJ-03-123 is a potent, CDK6-selective small-molecule degrader.Fórmula:C47H56N10O11Pureza:97.78% - 99.38%Cor e Forma:SolidPeso molecular:937.01Ref: TM-T5395
1mg87,00€2mg113,00€5mg177,00€10mg259,00€25mg409,00€50mg560,00€100mg800,00€500mg1.611,00€SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Cor e Forma:SolidPeso molecular:376.25Seliciclib
CAS:Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Fórmula:C19H26N6OPureza:97.15% - 99.89%Cor e Forma:White To Off-White SolidPeso molecular:354.45Flavopiridol hydrochloride
CAS:Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.Fórmula:C21H21Cl2NO5Pureza:98.87% - 99.88%Cor e Forma:SolidPeso molecular:438.3(E/Z)-Zotiraciclib citrate
(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.Fórmula:C29H32N4O8Cor e Forma:SolidPeso molecular:564.59PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Fórmula:C12H11N3OPureza:99.49% - >99.99%Cor e Forma:SolidPeso molecular:213.24Ref: TM-T6206
2mg34,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg64,00€25mg92,00€50mg138,00€100mg197,00€200mg295,00€LDC-4297 HCl (1453834-21-3(free base))
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.
Fórmula:C23H29ClN8OPureza:100%Cor e Forma:SolidPeso molecular:469.02ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Fórmula:C19H22O7SPureza:98.27%Cor e Forma:SolidPeso molecular:394.44Ref: TM-T16391
1mg48,00€1mL*10mM (DMSO)60,00€5mg71,00€10mg100,00€25mg172,00€50mg268,00€100mg404,00€200mg570,00€Senexin A
CAS:Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Fórmula:C17H14N4Pureza:99.74%Cor e Forma:SolidPeso molecular:274.32Ref: TM-T5673
1mg34,00€1mL*10mM (DMSO)71,00€5mg73,00€10mg94,00€25mg177,00€50mg323,00€100mg460,00€200mg622,00€Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Fórmula:C24H29N7O2Pureza:98% - 99.9%Cor e Forma:SolidPeso molecular:447.53AZD-5438
CAS:AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).Fórmula:C18H21N5O2SPureza:99.73% - 99.87%Cor e Forma:SolidPeso molecular:371.46BS194
CAS:BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.Fórmula:C20H27N5O3Pureza:99.85%Cor e Forma:SolidPeso molecular:385.46PF-06873600
CAS:PF-06873600: oral CDK inhibitor (CDK2/4/6), Ki 0.09-0.16 nM, potential anticancer drug.Fórmula:C20H27F2N5O4SPureza:98.77% - 99.55%Cor e Forma:SolidPeso molecular:471.52Ref: TM-T8463
1mg54,00€5mg114,00€1mL*10mM (DMSO)118,00€10mg178,00€25mg334,00€50mg557,00€100mg888,00€200mg1.198,00€DRB
CAS:DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)
Fórmula:C12H12Cl2N2O4Pureza:99.46% - 99.83%Cor e Forma:White To Off-White Crystalline SolidPeso molecular:319.14CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Fórmula:C18H15F5N8OPureza:99.37%Cor e Forma:SolidPeso molecular:454.36Ref: TM-T40290
1mg157,00€5mg378,00€1mL*10mM (DMSO)416,00€10mg612,00€25mg1.251,00€50mg1.972,00€100mg2.673,00€LSN2839567
CAS:LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.Fórmula:C25H28F2N8Pureza:99.14%Cor e Forma:SolidPeso molecular:478.54(R)-(+)-O-Demethylbuchenavianine
CAS:(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.Fórmula:C21H21NO4Cor e Forma:SolidPeso molecular:351.40Riviciclib hydrochloride
CAS:Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.Fórmula:C21H20ClNO5·HClPureza:99.51%Cor e Forma:SolidPeso molecular:438.3XL413
CAS:XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.Fórmula:C14H12ClN3O2Pureza:98.40% - 99.94%Cor e Forma:SolidPeso molecular:289.72
