CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 547 produtos de "CDK"
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EGFR/CDK2-IN-1
CAS:EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application inFórmula:C19H12BrClO2Cor e Forma:SolidPeso molecular:387.65EGFR/HER2/CDK9-IN-3
CAS:EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.Fórmula:C24H21N3O4S2Cor e Forma:SolidPeso molecular:479.57CDK7-IN-15
CAS:CDK7-IN-15 (Compound 8) is an effective CDK7 inhibitor for studying cancers associated with transcriptional dysregulation.Fórmula:C21H24F4N6OSPureza:99.27%Cor e Forma:SolidPeso molecular:484.51CDK7-IN-10
CAS:CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)Fórmula:C29H35N7O3Cor e Forma:SolidPeso molecular:529.63CDK7-IN-16
CAS:CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.Fórmula:C19H21F3N6O2SCor e Forma:SolidPeso molecular:454.47CDK9-IN-14
CAS:CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.Fórmula:C21H23F2N3O4Cor e Forma:SolidPeso molecular:419.42Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Fórmula:C13H15N5OSCor e Forma:SolidPeso molecular:289.36K 00546
CAS:K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Fórmula:C15H13F2N7O2S2Pureza:99.12%Cor e Forma:SolidPeso molecular:425.44CDK8-IN-7
CAS:CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Fórmula:C30H40N2Cor e Forma:SolidPeso molecular:428.65Cdc7-IN-15
CAS:Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Fórmula:C12H14N4OSCor e Forma:SolidPeso molecular:262.33CP681301
CAS:CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.Fórmula:C17H22N4OCor e Forma:SolidPeso molecular:298.38P18IN003
CAS:P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFórmula:C17H16N2O3Pureza:99%Cor e Forma:SolidPeso molecular:296.32CDK5 inhibitor 20-223
CAS:CDK5 inhibitor 20-223 is a potent CDK2/CDK5 inhibitor,anti-Colorectal Cancer (CRC), inhibiting cell migration and inducing cell cycle arrest.Fórmula:C19H19N3OCor e Forma:SolidPeso molecular:305.37Metralindole HCl
CAS:Metralindole is a reversible monoamine oxidase A (RIMA) inhibitor, it was investigated as a potential antidepressant.Fórmula:C15H18ClN3OPureza:98%Cor e Forma:SolidPeso molecular:291.78Metralindole
CAS:Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA).Fórmula:C15H17N3OCor e Forma:SolidPeso molecular:255.32Olomoucine II
CAS:Olomoucine II, a CDK inhibitor effective on Cdk1/2/4/7/9, also inhibits ERK2, ABCB1, and various virus replications, not effective on measles/influenza.Fórmula:C19H26N6O2Pureza:99.94%Cor e Forma:SolidPeso molecular:370.45SLM6
CAS:SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.Fórmula:C12H17N7O4Cor e Forma:SolidPeso molecular:323.31CDK9/10/GSK3β-IN-1
CAS:CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50Fórmula:C29H24ClN3O4SCor e Forma:SolidPeso molecular:546.04SMAPP1
CAS:SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells.Fórmula:C27H25N5O5S2Pureza:98%Cor e Forma:SolidPeso molecular:563.65SLK/STK10-IN-1
CAS:SLK/STK10-IN-1 is a selective and potent inhibitor of SLK and STK10 with potential antitumor activity.Fórmula:C17H13ClN2O3Pureza:99.34%Cor e Forma:SolidPeso molecular:328.75GW8510
CAS:GW8510 is a CDK2 and RRM2 inhibitor that affects DNA synthesis and antiproliferation in tumor cells. In mammalian aging models, GW851 prolongs lifespan.Fórmula:C21H15N5O3S2Pureza:99.32%Cor e Forma:SolidPeso molecular:449.51β-catenin-IN-3
CAS:β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces theFórmula:C19H20Br2N2OSCor e Forma:SolidPeso molecular:484.25Alsterpaullone, 2-Cyanoethyl
CAS:Alsterpaullone, 2-Cyanoethyl is a selective dual inhibitor of Cdk1/cyclin B and GSK-3β.Fórmula:C19H14N4O3Cor e Forma:SolidPeso molecular:346.34CDK-IN-10
CAS:CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.Fórmula:C18H18N4O2Pureza:97.07%Cor e Forma:SolidPeso molecular:322.36Zotiraciclib HCl
CAS:Zotiraciclib (TG02/SB1317) is a CDK/JAK2/FLT3 inhibitor potentially treating Myc-overexpressing cancers, including glioblastoma.Fórmula:C23H26Cl2N4OCor e Forma:SolidPeso molecular:445.388AG-012986
CAS:AG-012986: a selective CDK inhibitor with in vitro and in vivo antitumor effects; low IC50 in 14/18 cancer cell types; CAS# 486414-35-1.Fórmula:C22H23F2N5O2SCor e Forma:SolidPeso molecular:459.51Aloisine B
CAS:Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.Fórmula:C15H14ClN3Pureza:95.15%Cor e Forma:SolidPeso molecular:271.74Cdc7-IN-5
CAS:Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.Fórmula:C25H23N3O5Pureza:98.4%Cor e Forma:SolidPeso molecular:445.47Ref: TM-T10727
1mg96,00€5mg227,00€1mL*10mM (DMSO)250,00€10mg376,00€25mg620,00€50mg847,00€100mg1.169,00€BS-181
CAS:BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.Fórmula:C22H32N6Pureza:98%Cor e Forma:SolidPeso molecular:380.53FN-1501
CAS:FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively).Fórmula:C22H25N9OPureza:97.4%Cor e Forma:SolidPeso molecular:431.49Ref: TM-T15335
1mg87,00€5mg177,00€1mL*10mM (DMSO)203,00€10mg295,00€25mg537,00€50mg807,00€100mg1.099,00€CDK8-IN-4
CAS:CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).Fórmula:C20H18N4OCor e Forma:SolidPeso molecular:330.38CDK12-IN-3
CAS:CDK12-IN-3 is a CDK12 inhibitor with anti-tumor activity and can be used for the study of malignant tumors.Fórmula:C23H28F2N8OPureza:99.85%Cor e Forma:SolidPeso molecular:470.52Ref: TM-T14990
1mg101,00€5mg245,00€1mL*10mM (DMSO)254,00€10mg401,00€25mg842,00€50mg1.701,00€100mg2.250,00€Cdc7-IN-1
CAS:Cdc7-IN-1: selective ATP-competitive Cdc7 kinase inhibitor; IC50 0.6 nM at 1mM ATP; induces cancer cell death.Fórmula:C21H16ClN3O4Cor e Forma:SolidPeso molecular:409.82CLK1/2-IN-3
CAS:CLK1/2-IN-3 (Cpd-3) is a CLK1 and CLK2 inhibitor with antiproliferative activity that inhibits the activity of CLK and SRPK.Fórmula:C21H21N5O2Pureza:99.04%Cor e Forma:SolidPeso molecular:375.42CDK12-IN-E9
CAS:CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Fórmula:C24H30N6O2Cor e Forma:SolidPeso molecular:434.53AS2863619 free base
CAS:AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells.Fórmula:C16H12N8OCor e Forma:SolidPeso molecular:332.32CLK1-IN-1
CAS:CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).Fórmula:C24H16FN5OCor e Forma:SolidPeso molecular:409.42THZ1-R
CAS:THZ1-R is a non-covalent active analogue of THZ1, with the acrylamide group removed from THZ1, not covalently bind to the C312 cysteine residue of CDK7.Fórmula:C31H30ClN7O2Pureza:98%Cor e Forma:SolidPeso molecular:568.07CDK8/19-IN-51
CAS:CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Fórmula:C23H22N6O2Pureza:98.65% - 99.62%Cor e Forma:SoildPeso molecular:414.46CDK4/6/1 Inhibitor
CAS:CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Fórmula:C28H30F2N6Pureza:97.25% - 99.72%Cor e Forma:SolidPeso molecular:488.57CDK9-IN-10
CAS:CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.Fórmula:C22H16O5Pureza:99.8%Cor e Forma:SolidPeso molecular:360.36BRD7389
CAS:BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.Fórmula:C24H18N2O2Pureza:99.51%Cor e Forma:SolidPeso molecular:366.41hSMG-1 inhibitor 11e
CAS:hSMG-1 inhibitor 11e is an effective and selective inhibitor of hSMG-1 (IC50 <0.05 nM) and can be used in studies about cancer treatment.Fórmula:C26H27N7O3SPureza:99.89%Cor e Forma:SolidPeso molecular:517.6SEL120-34A
CAS:SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Fórmula:C15H18Br2N4Pureza:99.764% - 99.84%Cor e Forma:SolidPeso molecular:414.14Ref: TM-T10744
1mg612,00€5mg1.529,00€1mL*10mM (DMSO)1.835,00€10mg1.880,00€25mg2.178,00€50mg2.862,00€100mg3.870,00€HTH-01-091
CAS:HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3,Fórmula:C26H28Cl2N4O2Pureza:98.82%Cor e Forma:SolidPeso molecular:499.43Ref: TM-T24152
1mg281,00€5mg692,00€1mL*10mM (DMSO)775,00€10mg938,00€25mg1.454,00€50mg1.882,00€100mg2.375,00€BML-259
CAS:BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Fórmula:C14H16N2OSPureza:99.84%Cor e Forma:SolidPeso molecular:260.35Ref: TM-T36964
5mg48,00€1mL*10mM (DMSO)50,00€10mg80,00€25mg160,00€50mg264,00€100mg462,00€500mg982,00€CDK8-IN-1
CAS:CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Fórmula:C11H8F3N3OPureza:98.48%Cor e Forma:SolidPeso molecular:255.2Ref: TM-T10740
1mg87,00€5mg216,00€1mL*10mM (DMSO)240,00€10mg311,00€25mg525,00€50mg707,00€100mg944,00€AS-0141
CAS:AS-0141 (Cdc7-IN-6) 是一种有效的 Cdc7 激酶抑制剂 (IC50=4 nM)，具有抗肿瘤活性。Cdc7 是一种丝氨酸苏氨酸蛋白激酶酶，在细胞周期中对 DNA 复制的启动至关重要。Fórmula:C21H22F3N5O4Pureza:99.97%Cor e Forma:SolidPeso molecular:465.43SJ572403
CAS:SJ572403 inhibits p27 protein, Kd 2.2 mM at D2 subdomain of p27-KID; useful in disordered protein disease research.Fórmula:C13H17N5O2Pureza:99.93%Cor e Forma:SolidPeso molecular:275.31Ref: TM-T16889
1mg39,00€5mg86,00€1mL*10mM (DMSO)92,00€10mg119,00€25mg231,00€50mg371,00€100mg537,00€200mg710,00€
