CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 542 produtos de "CDK"
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CDK7-IN-20
CDK7-IN-20: potent, irreversible CDK7 inhibitor, IC50 of 4nM, 206x selectivity vs. other CDKs, potential for ADPKD study.Fórmula:C30H26N6O3Cor e Forma:SolidPeso molecular:518.57CDK7-IN-13
CAS:CDK7-IN-13 (compound 1) is an effective CDK7 inhibitor for investigating cancers associated with transcriptional dysregulation.Fórmula:C20H23F3N6OSPureza:99.22%Cor e Forma:SolidPeso molecular:452.5Indirubin-3'-monoxime-5-sulphonic acid
CAS:Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of GSK-3β, CDK5, and CDK1 with IC50s of 80nM,5 nM, and 7 nM, respectively.Fórmula:C16H11N3O5SPureza:98%Cor e Forma:SolidPeso molecular:357.34BSJ-01-175
CAS:BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.Fórmula:C30H33ClN6O2Cor e Forma:SolidPeso molecular:545.08MDK6204
CAS:MDK6204 is a selective inhibitor of CLK1 and CLK2.Fórmula:C20H20N6OPureza:98%Cor e Forma:SolidPeso molecular:360.41XIE18-6
CAS:XIE18-6 is a novel INK4C inhibitor that blocks p18 activity and promotes ex vivo expansion of human and murine hematopoietic stem cells.Fórmula:C18H15NO6SPureza:99.712%Cor e Forma:SolidPeso molecular:373.38CDK4/6-IN-14
CAS:CDK4/6-IN-14: potent CDK4/6 inhibitor, IC50s 10/16 nM, >60-fold selectivity over CDKs 1/2/7/9, selective across 205 kinases.Fórmula:C24H27ClFN7OCor e Forma:SolidPeso molecular:483.97Ipivivint
CAS:Ipivivint: orally active, potent CLK inhibitor; hinders CLK1, CLK2, & CLK3; curbs Wnt signaling & SRSF phosphorylation for cancer research.Fórmula:C26H21FN8Cor e Forma:SolidPeso molecular:464.5EGFR/HER2/CDK9-IN-1
CAS:EGFR/HER2/CDK9-IN-1 is a potent inhibitor (IC50: EGFR 90.17 nM, HER2 131.39 nM, CDK9 67.04 nM) with notable anti-tumor activity.Fórmula:C23H21N3O3S2Cor e Forma:SolidPeso molecular:451.56CDK7-IN-2
CAS:CDK7-IN-2 inhibits CDK7, essential for RNA polymerase II activation and cell cycle control, with cancer research potential.Fórmula:C26H39N7O3Cor e Forma:SolidPeso molecular:497.63CDK4/6-IN-7
CAS:CDK4/6-IN-7 is an oral, potent CDK4/6 inhibitor with IC50s of 1.58/4.09 nM, crucial for breast cancer studies.Fórmula:C18H18ClN5O3Cor e Forma:SolidPeso molecular:387.82CDK8-IN-6
CAS:CDK8-IN-6 (compound 9) is a potent inhibitor of cyclin-dependent kinase 8 (CDK8) (Kd: 13 nM), CDK8-IN-6 showed potential research value in AML cancers.Fórmula:C26H37ClN2Cor e Forma:SolidPeso molecular:413.04CDK7-IN-12
CAS:CDK7-IN-12 inhibits CDK7 to control transcription and cell cycle, halting tumor growth in vitro/vivo with cancer research potential.Fórmula:C20H19F3N6Cor e Forma:SolidPeso molecular:400.4Crozbaciclib fumarate
CAS:Crozbaciclib fumarate is a CDK4/6 inhibitor with IC 50 s of 3 and 1 nM, respectively.Fórmula:C32H34F2N6O4Cor e Forma:SolidPeso molecular:604.65EGFR/CDK2-IN-1
CAS:EGFR/CDK2-IN-1, an inhibitor of both EGFR and CDK2, demonstrates effective cytotoxicity towards MCF7 and HepG2 cells, suggesting its potential application inFórmula:C19H12BrClO2Cor e Forma:SolidPeso molecular:387.65KH-CB19
CAS:KH-CB19 is an effective and highly specific inhibitor of the CDC2-like kinase isoforms 1 and 4 (CLK1/CLK4).Fórmula:C15H13Cl2N3O2Cor e Forma:SolidPeso molecular:338.19Ref: TM-T15657
2mgA consultar5mgA consultar25mgA consultar50mgA consultar100mgA consultar1mL*10mM (DMSO)A consultarCdc7-IN-14
CAS:Cdc7-IN-14 (compound 82) is a potent CDC7 inhibitor with an IC50 < 1 nM, promising for cancer research.Fórmula:C18H20N4O2SCor e Forma:SolidPeso molecular:356.44Cdc7-IN-9
CAS:Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].Fórmula:C15H17N5OSCor e Forma:SolidPeso molecular:315.39EGFR/HER2/CDK9-IN-2
CAS:EGFR/HER2/CDK9-IN-2 inhibits EGFR, HER2, CDK9 with IC50s: 145.35, 129.07, 117.13 nM; strong antitumor effects.Fórmula:C23H20N4O5S2Cor e Forma:SolidPeso molecular:496.56EGFR/HER2/CDK9-IN-3
CAS:EGFR/HER2/CDK9-IN-3 inhibits EGFR (191.08 nM IC50), HER2 (132.65 nM), CDK9 (113.98 nM); shows anti-tumor effects.Fórmula:C24H21N3O4S2Cor e Forma:SolidPeso molecular:479.57
