Microtúbulo associado
Os inibidores de proteínas associadas aos microtúbulos têm como alvo as proteínas que interagem com os microtúbulos, os componentes estruturais do citoesqueleto da célula que são essenciais para a divisão celular. Essas proteínas regulam a estabilidade e a dinâmica dos microtúbulos durante a mitose. A inibição de proteínas associadas aos microtúbulos pode interromper a função dos microtúbulos, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas de rápida divisão. Esses inibidores são amplamente utilizados na pesquisa do câncer e no desenvolvimento de medicamentos. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteínas associadas aos microtúbulos de alta qualidade para apoiar sua pesquisa em divisão celular, dinâmica do citoesqueleto e terapia do câncer.
Foram encontrados 262 produtos de "Microtúbulo associado"
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JG-23
CAS:<p>JG-23, a 4-chloro-modified analog, effectively induces t-tau degradation and demonstrates robust metabolic stability, exhibiting an extended half-life (T1/2) of</p>Fórmula:C19H16ClN3OS2Cor e Forma:SolidPeso molecular:401.93Epothilone E
CAS:<p>Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumor</p>Fórmula:C26H39NO7SCor e Forma:SolidPeso molecular:509.66Tubulin polymerization-IN-35
<p>Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.</p>Fórmula:C31H35N3O5Cor e Forma:SolidPeso molecular:529.63AMXI-5001 hydrochloride
<p>AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.</p>Fórmula:C25H21ClFN5O3Cor e Forma:SolidPeso molecular:493.92Lisavanbulin
CAS:<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Fórmula:C26H29N9O3Cor e Forma:SolidPeso molecular:515.57AM-9022
CAS:<p>AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].</p>Fórmula:C27H36F2N6O4SCor e Forma:SolidPeso molecular:578.67EX05
CAS:<p>EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.</p>Fórmula:C26H30F2N4O5SCor e Forma:SolidPeso molecular:548.60TACC3 inhibitor 2
CAS:<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Fórmula:C20H22FN5O2Cor e Forma:SolidPeso molecular:383.419Tubulin polymerization-IN-77
CAS:<p>Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.</p>Fórmula:C22H19BrF3NO7Cor e Forma:SolidPeso molecular:546.288Tubulin polymerization-IN-63
CAS:<p>Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.</p>Fórmula:C20H24ClCuN5O2SCor e Forma:SolidPeso molecular:497.5Monomethyl auristatin E intermediate-17
CAS:<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Fórmula:C27H35NO7SPeso molecular:517.63TPI-287
CAS:<p>TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.</p>Fórmula:C46H63NO15Cor e Forma:SolidPeso molecular:869.99PROTAC α-synuclein degrader 6
CAS:<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>Fórmula:C37H39N5O9SPeso molecular:729.80Tubulin inhibitor 49
CAS:<p>Tubulin inhibitor 49 (Compound 18) is an inhibitor of tubulin polymerization with an IC50 of 48 μM. It disrupts the microtubule network of cells, causing cell cycle arrest in the G2 phase, and exhibits cytotoxicity with an IC50 of 8.8 μM in HeLa cells.</p>Fórmula:C18H14F3N3OSCor e Forma:SolidPeso molecular:377.383Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Fórmula:C27H28N2O6Cor e Forma:SolidPeso molecular:476.52Tasidotin hydrochloride
CAS:<p>Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.</p>Fórmula:C32H59ClN6O5Pureza:98%Cor e Forma:SolidPeso molecular:643.30Tubulin inhibitor 16
<p>Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].</p>Fórmula:C16H12FNO2Cor e Forma:SolidPeso molecular:269.27Tau ligand-1
CAS:<p>Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.</p>Fórmula:C17H16FN3OCor e Forma:SolidPeso molecular:297.327Icafolin-methyl
CAS:<p>Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.</p>Fórmula:C18H18F2N2O5Cor e Forma:SolidPeso molecular:380.343Tubulin polymerization-IN-74
CAS:<p>Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.</p>Fórmula:C14H11NSCor e Forma:SolidPeso molecular:225.309
