Microtúbulo associado
Os inibidores de proteínas associadas aos microtúbulos têm como alvo as proteínas que interagem com os microtúbulos, os componentes estruturais do citoesqueleto da célula que são essenciais para a divisão celular. Essas proteínas regulam a estabilidade e a dinâmica dos microtúbulos durante a mitose. A inibição de proteínas associadas aos microtúbulos pode interromper a função dos microtúbulos, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas de rápida divisão. Esses inibidores são amplamente utilizados na pesquisa do câncer e no desenvolvimento de medicamentos. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteínas associadas aos microtúbulos de alta qualidade para apoiar sua pesquisa em divisão celular, dinâmica do citoesqueleto e terapia do câncer.
Foram encontrados 262 produtos de "Microtúbulo associado"
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Tubulin polymerization-IN-32
<p>Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.</p>Fórmula:C29H30N2O7Cor e Forma:SolidPeso molecular:518.56JC168
CAS:<p>JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.</p>Fórmula:C26H40O7Cor e Forma:SolidPeso molecular:464.592Myoseverin B
CAS:<p>Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.</p>Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582Antitubulin agent 1
<p>Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.</p>Fórmula:C21H19N3O3Cor e Forma:SolidPeso molecular:361.39Alfalone
CAS:<p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>Fórmula:C17H14O5Cor e Forma:SolidPeso molecular:298.29TTBK1/2-IN-1
CAS:<p>TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.</p>Fórmula:C17H16N4OCor e Forma:SolidPeso molecular:292.335Dictyostatin
CAS:<p>Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.</p>Fórmula:C32H52O6Cor e Forma:SolidPeso molecular:532.75AMG28
CAS:<p>AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.</p>Fórmula:C20H20N4OCor e Forma:SolidPeso molecular:332.399Sagopilone
CAS:Sagopilone: synthetic epothilone, inhibits cell division and induces apoptosis, effective in MDR tumors, not P-gp substrate.Fórmula:C30H41NO6SCor e Forma:SolidPeso molecular:543.71Tubulin inhibitor 19
<p>Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.</p>Fórmula:C21H23NO5Cor e Forma:SolidPeso molecular:369.41Antitumor agent-200
CAS:<p>Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.</p>Fórmula:C19H21FN2O3SeCor e Forma:SolidPeso molecular:423.34Tubulin inhibitor 22
<p>Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.</p>Fórmula:C20H17BrFNO4Cor e Forma:SolidPeso molecular:434.26Tubulin polymerization-IN-34
<p>"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."</p>Fórmula:C31H35N3O6Cor e Forma:SolidPeso molecular:545.63TTBK1/2-IN-3
CAS:<p>TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).</p>Fórmula:C21H22N4OCor e Forma:SolidPeso molecular:346.426PM-060184
CAS:<p>PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.</p>Fórmula:C31H45N3O7Pureza:98%Cor e Forma:SolidPeso molecular:571.7Tubulin polymerization-IN-8
CAS:<p>Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.</p>Fórmula:C21H24N4O4SCor e Forma:SolidPeso molecular:428.5Tubulin inhibitor 15
<p>Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].</p>Fórmula:C16H12FNO2Cor e Forma:SolidPeso molecular:269.27Tubulin polymerization-IN-75
CAS:<p>Tubulin polymerization-IN-75 (Compound 6) is an inhibitor of tubulin polymerization, with an IC50 value of 30 μM. It effectively suppresses the proliferation of cancer cells Huh7 and 293T, demonstrating IC50 values of 14.3 μM and 13.8 μM, respectively.</p>Fórmula:C14H11NOCor e Forma:SolidPeso molecular:209.243Ombrabulin
CAS:<p>Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.</p>Fórmula:C21H26N2O6Pureza:98%Cor e Forma:SolidPeso molecular:402.44
