Microtúbulo associado
Os inibidores de proteínas associadas aos microtúbulos têm como alvo as proteínas que interagem com os microtúbulos, os componentes estruturais do citoesqueleto da célula que são essenciais para a divisão celular. Essas proteínas regulam a estabilidade e a dinâmica dos microtúbulos durante a mitose. A inibição de proteínas associadas aos microtúbulos pode interromper a função dos microtúbulos, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas de rápida divisão. Esses inibidores são amplamente utilizados na pesquisa do câncer e no desenvolvimento de medicamentos. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteínas associadas aos microtúbulos de alta qualidade para apoiar sua pesquisa em divisão celular, dinâmica do citoesqueleto e terapia do câncer.
Foram encontrados 261 produtos de "Microtúbulo associado"
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AC 7739
CAS:<p>AC 7739 is a microtubule protein binding agent with anticancer and antitumor activity that inhibits advanced solid tumors and in situ transplanted tumors.</p>Fórmula:C18H22ClNO4Pureza:99.38% - 99.55%Cor e Forma:SoildPeso molecular:351.83Tubulin inhibitor 6
CAS:<p>Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.</p>Fórmula:C20H14ClNO2SPureza:99.05%Cor e Forma:SolidPeso molecular:367.85DM4
CAS:<p>DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.</p>Fórmula:C38H54ClN3O10SPureza:98.15%Cor e Forma:SolidPeso molecular:780.37Tirbanibulin Mesylate
CAS:<p>Tirbanibulin Mesylate (KX01 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).</p>Fórmula:C27H33N3O6SPureza:99%Cor e Forma:SolidPeso molecular:527.63Zagotenemab
CAS:<p>Zagotenemab: humanized antibody targeting tau protein to study neurological disorders, including Alzheimer's.</p>Pureza:95% - > 95%Cor e Forma:LiquidPeso molecular:145.3 kDaVerubulin hydrochloride
CAS:<p>Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic</p>Fórmula:C17H18ClN3OPureza:98.29% - 99.77%Cor e Forma:SolidPeso molecular:315.8Entasobulin
CAS:<p>Entasobulin is an inhibitor of β-tubulin polymerization. It has a potential anticancer activity.</p>Fórmula:C26H18ClN3O2Pureza:98.40%Cor e Forma:SolidPeso molecular:439.89BNC105
CAS:BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.Fórmula:C20H20O7Pureza:96.57%Cor e Forma:SolidPeso molecular:372.37Bepranemab
CAS:<p>Bepranemab (UCB 0107) - humanized IgG4 monoclonal antibody targeting tau (235-250) for Alzheimer's research.</p>Pureza:99% (SDS-PAGE); 96.8% (SEC-HPLC) - 99% (SDS-PAGE); 96.8% (SEC-HPLC)Cor e Forma:LiquidTilavonemab
CAS:<p>Tilavonemab (ABBV-8E12), a humanized anti-tau antibody, halts tau uptake in neurons and may help with Alzheimer's research.</p>Pureza:95.2% (SDS-PAGE); 96.6% (SEC-HPLC) - 95.2% (SDS-PAGE); 96.6% (SEC-HPLC)Cor e Forma:LiquidTubulin/PARP-IN-1
<p>Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with anti-endometrial cancer activity. It exhibits inhibitory concentration (IC50) values of 74 nM for PARP1, 109 nM for PARP2, and 1.4 μM for microtubules/tubulin. Tubulin/PARP-IN-1 induces apoptosis and autophagy, causing cell cycle arrest at the G2/M phase.</p>Fórmula:C19H13FO3Peso molecular:308.08487Modified MMAF
CAS:<p>Modified MMAF, an ADC cytotoxin, aids in ADC synthesis for targeted cancer research.</p>Fórmula:C45H73N7O8Cor e Forma:SolidPeso molecular:840.1Tubulin inhibitor 50
<p>Tubulin inhibitor 50 (compound 07) is a microtubule protein inhibitor that enhances mitochondrial reactive oxygen species levels. It exhibits anticancer activity in HeLa cells with an IC50 value of 0.46 μM, while showing low toxicity in normal cell lines.</p>Fórmula:C16H10ClFN2O2Cor e Forma:SolidPeso molecular:316.04148Vinzolidine
CAS:<p>Vinzolidine is a semi-synthetic vinca alkaloid. It exerts cytotoxic effects on tumor cells by inhibiting cell division through disruption of tubulin polymerization. Vinzolidine can be utilized in research to investigate synergy with other chemotherapy or biotherapy drugs, as well as cancer cell tolerance or resistance, and to explore strategies to overcome these challenges.</p>Fórmula:C48H58ClN5O9Cor e Forma:SolidPeso molecular:884.46PM050489
CAS:<p>PM050489, a polyketone inhibitor from Lithoplocamia lithistoides, halts mitosis at 26.4 nM IC50 and aids cancer research.</p>Fórmula:C31H44ClN3O7Cor e Forma:SolidPeso molecular:606.15Antiproliferative agent-66
Antiproliferative agent-66 (Compound B3) is an antiproliferative compound that induces apoptosis and causes cell cycle arrest. It demonstrates IC50 values ranging from 2.03 to 3.6 µM against SH-SY5Y neuroblastoma, HT-29 colorectal adenocarcinoma, and fibroblasts. Additionally, Antiproliferative agent-66 functions as a microtubule polymerization inhibitor with an IC50 of 0.79 µM.Fórmula:C18H15N3SCor e Forma:SolidPeso molecular:305.397AADvac 1 TFA
AADvac 1 TFA is an active tau peptide vaccine utilized in Alzheimer's disease research. It is formed by conjugating the regulatory peptide 294KDNIKHVPGGGS305, which drives tau oligomerization, with keyhole limpet hemocyanin (KLH), and is formulated with aluminum hydroxide.Tubulin polymerization-IN-49
<p>Tubulin polymerization-IN-49 (compound 12d), a potent inhibitor of tubulin polymerization, binds to the colchicine site on tubulin, subsequently inducing cell</p>Fórmula:C20H24O5Cor e Forma:SolidPeso molecular:344.4Phomopsin A
CAS:<p>Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis.</p>Fórmula:C36H45ClN6O12Pureza:98%Cor e Forma:SolidPeso molecular:789.23Diminutol
CAS:<p>Diminutol, a purine derivative, inhibits NQO1 (Ki=1.72μM), affects tubulin polymerization, and disrupts mitosis at 50μM without impacting Cdk1 or actin.</p>Fórmula:C19H26N6OSCor e Forma:SolidPeso molecular:386.51Ceratamine A
CAS:<p>Ceratamine A, from Pseudoceratina sponge, is a cytotoxic, microtubule-stabilizing antimitotic alkaloid.</p>Fórmula:C17H16Br2N4O2Pureza:98%Cor e Forma:SolidPeso molecular:468.14Tubulin polymerization-IN-53
<p>Tubulin polymerization-IN-53 (compound 4b) serves as an inhibitor of β-tubulin polymerization and is capable of arresting the cell cycle at the G2/M stage.</p>Cor e Forma:Odour SolidTubulin polymerization-IN-44
<p>Tubulinpolymer-in-44 (compound 7w) effectively inhibits Tubulin with an IC50 value of 0.21 μM and induces apoptosis by arresting the G2/M phase, making it</p>Fórmula:C19H15Cl2N3O3SCor e Forma:SolidPeso molecular:436.31Dihydrocephalomannine
CAS:<p>Dihydrocephalomannine is similar to paclitaxel, showing reduced cytotoxicity and tubulin binding.</p>Fórmula:C45H55NO14Pureza:98%Cor e Forma:SolidPeso molecular:833.928Anti-α-Tubulin Antibody, AF555 conjugate
<p>Anti-α-Tubulin Antibody, AF555 conjugate, is a mouse-derived monoclonal antibody conjugated with the red fluorescent dye Alexa Fluor 555, designed for the</p>Cor e Forma:SolidAnticancer agent 270
<p>Anticanceragent 270 (Compound 8e) is a microtubule protein inhibitor with an IC50 of 1.02 μM against MCF-7 breast cancer cells. It exerts significant antiproliferative activity on breast cancer cells through a dual mechanism of inducing apoptosis and destabilizing microtubules. Anticanceragent 270 is useful for cancer research.</p>Cor e Forma:Odour Solid7-Epi-docetaxel
CAS:<p>7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel.</p>Fórmula:C43H53NO14Pureza:98%Cor e Forma:SolidPeso molecular:807.88Epothilone F
CAS:<p>Epothilone F, an active metabolite of Epothilone D with a hydroxymethyl on thiazole, disrupts cell division, shows promise over taxanes, and is water-soluble.</p>Fórmula:C27H41NO7SCor e Forma:SolidPeso molecular:523.68Tubulin inhibitor 21
<p>Compound 6f, a chalcone-melatonin hybrid, is a potent tubulin inhibitor with IC50=0.26μM in SW480 cells, less toxic to non-cancer cells.</p>Fórmula:C28H25N3O4SCor e Forma:SolidPeso molecular:499.58PROTAC tubulin-Degrader-1
<p>PROTAC tubulin-Degrader-1 (Compound W13) functions as an inhibitor of PROTAC tubulin and exhibits anti-tumor activity against human lung cancer.</p>Cor e Forma:Odour SolidAnticancer agent 139
<p>Compound 6h (Anticancer Agent 139) exhibits potent anticancer activity, engaging in a π-cationic interaction with Lys352 of Tubulin and demonstrating high</p>Fórmula:C16H12F3N3OCor e Forma:SolidPeso molecular:319.28Anhydrovinblastine sulfate
Anhydrovinblastine sulfate is a monoterpene indole alkaloid that can be extracted from the leaves of Catharanthus roseus.Fórmula:C46H60N4O16S2Peso molecular:988.34457Tubulin inhibitor 37
<p>Tubulin Inhibitor 37 (Compound 12) effectively impedes tubulin aggregation (IC50 = 1.3 µM) and demonstrates antiproliferative activity against human tumor cell</p>Fórmula:C16H10Cl2N6OCor e Forma:SolidPeso molecular:373.2Tubulin inhibitor 36
<p>Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells,</p>Fórmula:C16H13ClN6SCor e Forma:SolidPeso molecular:356.83KGP591
<p>KGP591, a tubulin polymerization inhibitor with an IC50 of 0.57 µM, effectively induces G2/M arrest, inhibits cell migration, and disrupts microtubule structure</p>Fórmula:C24H21NO5Cor e Forma:SolidPeso molecular:403.43Microtubule stabilizing agent-1
<p>Compound 3l, a paclitaxel derivative known as Microtubule Stabilizing Agent-1, effectively enhances tubulin polymerization and demonstrates antitumor efficacy [</p>Fórmula:C45H55NO13Cor e Forma:SolidPeso molecular:817.92T-808
CAS:<p>T-808 is a tau tracer which may be used in radiographic labeling of Tau aggregates during Alzheimer's disease.</p>Fórmula:C17H19FN4Cor e Forma:SolidPeso molecular:298.36Tubulin polymerization-IN-46
<p>Tubulin polymerization-IN-46 (compound 9q) is a microtubule/tubulin inhibitor that impedes tubulin polymerization, induces apoptosis, and arrests MCF-7 breast</p>Fórmula:C22H25NO6Cor e Forma:SolidPeso molecular:399.4420-O-Demethyl-AP3
CAS:<p>20-O-Demethyl-AP3, a derivative of the microtubule-inhibiting antitumor agent Ansamitocin P-3, is a secondary metabolite.</p>Fórmula:C31H41ClN2O9Cor e Forma:SolidPeso molecular:621.12Tubulin polymerization-IN-78
<p>Tubulin polymerization-IN-78 (compound 10a) is an inhibitor of tubulin polymerization, with an IC50 value of 2.69 μM. It exhibits antiproliferative activity.</p>Cor e Forma:Odour Solid7-Epi-10-oxo-docetaxel
CAS:<p>7-Epi-10-oxo-docetaxel (Docetaxel Impurity 2) is an impurity of docetaxel detected by HPLC.</p>Fórmula:C43H51NO14Pureza:98%Cor e Forma:SolidPeso molecular:805.86Tubulin inhibitor 38
<p>Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cell</p>Fórmula:C17H13ClN6OSCor e Forma:SolidPeso molecular:384.84Microtubule-associated protein tau (26-44)
<p>Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.</p>Fórmula:C83H127N25O34SPureza:98%Cor e Forma:SolidPeso molecular:2051.11Microtubule destabilizing agent-1
CAS:<p>Compound 12b is a hydroxamic acid-based MDA with stable metabolism, high bioavailability, and strong antitumor properties.</p>Fórmula:C22H26N4O4Cor e Forma:SolidPeso molecular:410.47Tubulin polymerization-IN-48
<p>Tubulin polymerization-IN-48 (Compound 4k) is an inhibitor of tubulin polymerization, moderately disrupting the microtubule network.</p>Fórmula:C20H15Cl2N3OCor e Forma:SolidPeso molecular:384.26Cys-McMMAF
CAS:<p>Cys-McMMAF, a microtubule-disrupting agent linked to an anti-5T4 antibody, shows antitumor effects in mouse models.</p>Fórmula:C52H83N7O13SCor e Forma:SolidPeso molecular:1046.32Tubulin inhibitor 24
CAS:<p>Tubulin inhibitor 24 is a potent inhibitor that can inhibit tubulin polymerization.</p>Fórmula:C22H21N3O3Pureza:99.99%Cor e Forma:SolidPeso molecular:375.42Pironetin
CAS:<p>Pironetin, from Streptomyces, inhibits microtubule polymerization and tumor growth, and causes cell cycle arrest.</p>Fórmula:C19H32O4Pureza:98%Cor e Forma:SolidPeso molecular:324.45Sudocetaxel
CAS:<p>Sudocetaxel is a compound that serves as a microtubule depolymerization inhibitor, specifically designed for the pH-sensitive delivery of docetaxel.</p>Fórmula:C48H59NO16Cor e Forma:SolidPeso molecular:905.98Tubulin polymerization-IN-50
<p>Tubulin Polymerization-IN-50 (compound 7n) serves as an inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells and inducing cell</p>Fórmula:C24H20FN3O3Cor e Forma:SolidPeso molecular:417.43
