c-Myc
Os inibidores de c-Myc têm como alvo a proteína c-Myc, um fator de transcrição que desempenha um papel crucial no crescimento celular, proliferação e apoptose. c-Myc regula a expressão de numerosos genes envolvidos no ciclo celular e é frequentemente superexpresso em vários tipos de câncer, levando a uma proliferação celular descontrolada e ao crescimento tumoral. Inibir o c-Myc pode interromper esses processos, induzindo a parada do ciclo celular e a apoptose em células cancerígenas. Os inibidores de c-Myc são ferramentas importantes na pesquisa do câncer e no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de c-Myc de alta qualidade para apoiar sua pesquisa em oncologia, regulação do ciclo celular e controle transcricional.
Foram encontrados 69 produtos de "c-Myc"
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CSI86
<p>CSI86 is a PROTAC degrader targeting MYC, exhibiting antiproliferative activity (IC50: 13-18 μM).</p>Fórmula:C48H50F9N7O7SCor e Forma:SolidPeso molecular:1040WBC100
CAS:<p>WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway</p>Fórmula:C25H33NO7Pureza:98%Cor e Forma:SolidPeso molecular:459.53Anticancer agent 263
<p>Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.</p>Fórmula:C13H20N2O6Cor e Forma:SolidPeso molecular:300.308c-Myc inhibitor 7
CAS:<p>c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.</p>Fórmula:C35H30N6O5Cor e Forma:SoildPeso molecular:614.65Anticancer agent 84
CAS:<p>Anticancer agent 84 inhibits c-MYC transcription by stabilizing G4 structures, aiding cancer research.</p>Fórmula:C57H67N7O9Cor e Forma:SolidPeso molecular:994.18VGN50
<p>VGN50 is a bioactive molecule that mimics the function of K-Rta, capable of downregulating MYC-mediated gene transcription. VGN50 exhibits antitumor activity.</p>Fórmula:C121H218N46O32Peso molecular:2827.68453c-Myc inhibitor 13
<p>c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.</p>Fórmula:C30H39N9OPeso molecular:541.32776Cotylenin A
CAS:<p>Cotylenin A is a phenanthraquinone compound that synergistically works with vitamin K2 to induce monocyte differentiation and growth arrest. It also inhibits c-Myc expression while inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A is applicable in acute myeloid leukemia research.</p>Fórmula:C33H50O11Cor e Forma:SolidPeso molecular:622.744H122
<p>H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)</p>Fórmula:C45H45ClFN5O8Cor e Forma:SolidPeso molecular:838.319PROTAC LZK-IN-1
CAS:<p>PROTAC LZK-IN-1 (Compound 21A) is a PROTAC molecule that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). At a concentration of 10 μM, PROTAC LZK-IN-1 facilitates the degradation of LZK and inhibits the expression of p53 and c-MYC, leading to reduced viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. This compound is applicable in anticancer research.</p>Fórmula:C51H64F2N10O5SCor e Forma:SolidPeso molecular:967.18KL4-219A
<p>KL4-219A is a selective covalent degrader of the MYC, inhibiting MYC transcriptional activity and degrading MYC in a proteasome-dependent manner .</p>Fórmula:C20H24N2O2SPureza:99.68%Cor e Forma:SolidPeso molecular:356.48VPC-70063
CAS:<p>VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX.</p>Fórmula:C16H12F6N2SPureza:99.98%Cor e Forma:SolidPeso molecular:378.34sAJM589
CAS:<p>sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.</p>Fórmula:C16H10N2OPureza:98%Cor e Forma:SolidPeso molecular:246.26IRES-C11
CAS:<p>IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.</p>Fórmula:C13H11Cl2NO4Pureza:99.89%Cor e Forma:SolidPeso molecular:316.14Mycro 3
CAS:<p>Mycro 3 is potent and selective for c-Myc in whole cell assays.</p>Fórmula:C24H17ClF2N6O4Pureza:99.51% - 99.61%Cor e Forma:SolidPeso molecular:526.88Saxagliptin
CAS:<p>Saxagliptin (BMS-477118) is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.</p>Fórmula:C18H25N3O2Pureza:99.17% - 99.95%Cor e Forma:SolidPeso molecular:315.41(S)-10-Hydroxycamptothecin
CAS:<p>(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.</p>Fórmula:C20H16N2O5Pureza:99.09% - 99.81%Cor e Forma:SolidPeso molecular:364.35Mollugin
CAS:<p>Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.</p>Fórmula:C17H16O4Pureza:99.87% - ≥95%Cor e Forma:SolidPeso molecular:284.31ML327
CAS:<p>ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).</p>Fórmula:C19H18N4O4Pureza:98.47%Cor e Forma:SolidPeso molecular:366.3710074-G5
CAS:<p>10074-G5 is an inhibitor of c-Myc-Max dimerization.</p>Fórmula:C18H12N4O3Pureza:99.51% - 99.67%Cor e Forma:SolidPeso molecular:332.31
