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PLK

PLK

Os inibidores de quinases Polo-like (PLK) têm como alvo as PLKs, uma família de quinases serina/treonina essenciais para várias fases da divisão celular, incluindo entrada na mitose, montagem do fuso e citocinese. As PLKs são críticas para a execução adequada do ciclo celular, e sua desregulação é frequentemente associada ao câncer. Inibir as PLKs pode induzir parada do ciclo celular e apoptose em células cancerígenas, tornando esses inibidores ferramentas importantes na pesquisa e terapia do câncer. Na CymitQuimica, oferecemos uma gama de inibidores de PLK de alta qualidade para apoiar sua pesquisa em mitose, controle do ciclo celular e oncologia.

Foram encontrados 25 produtos de "PLK"

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  • Plogosertib
    Targetmol
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    Plogosertib

    CAS:
    Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.
    Fórmula:C34H48N8O3
    Pureza:99.22% - 99.85%
    Cor e Forma:Solid
    Peso molecular:616.797

    Ref: TM-T71399

    1mg
    216,00€
    5mg
    567,00€
    10mg
    847,00€
    25mg
    1.473,00€
    50mg
    2.043,00€
    100mg
    2.642,00€
    1mL*10mM (DMSO)
    752,00€
  • PLK1-IN-11
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    PLK1-IN-11

    CAS:
    PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.
    Fórmula:C12H11N5O
    Cor e Forma:Solid
    Peso molecular:241.249

    Ref: TM-T205548

    10mg
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    50mg
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  • CD 10899
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    CD 10899

    CAS:
    CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].
    Fórmula:C34H50N8O4
    Cor e Forma:Solid
    Peso molecular:634.81

    Ref: TM-T86023

    10mg
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    50mg
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  • PLK1-IN-5
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    PLK1-IN-5

    CAS:
    PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].
    Fórmula:C28H39N7O3
    Cor e Forma:Solid
    Peso molecular:521.65

    Ref: TM-T87222

    10mg
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    50mg
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  • IIP0943
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    IIP0943

    CAS:
    IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.
    Fórmula:C26H28N6O3S
    Cor e Forma:Solid
    Peso molecular:504.604

    Ref: TM-T206115

    10mg
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    50mg
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