PKC
Os inibidores de PKC (Proteína Cinase C) têm como alvo a família de cinases serina/treonina PKC, que estão envolvidas em uma ampla gama de processos celulares, incluindo regulação do ciclo celular, apoptose e diferenciação. A PKC desempenha um papel crucial nas vias de transdução de sinais que influenciam a proliferação e sobrevivência celular. Inibir a PKC pode levar a alterações na progressão do ciclo celular, tornando esses inibidores valiosos na pesquisa relacionada ao câncer, neurobiologia e doenças cardiovasculares. Na CymitQuimica, oferecemos uma seleção diversificada de inibidores de PKC de alta qualidade para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.
Foram encontrados 102 produtos de "PKC"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
N-Desmethyltamoxifen hydrochloride
CAS:<p>N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.</p>Fórmula:C25H28ClNOPureza:99.15%Cor e Forma:SolidPeso molecular:393.95CMPD101
CAS:<p>CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).</p>Fórmula:C24H21F3N6OPureza:99.01% - 99.04%Cor e Forma:SolidPeso molecular:466.46Bisindolylmaleimide VIII acetate
CAS:<p>Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.</p>Fórmula:C26H26N4O4Pureza:99.27%Cor e Forma:SolidPeso molecular:458.51Mitoxantrone dihydrochloride
CAS:<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Fórmula:C22H30Cl2N4O6Pureza:97.05% - >99.99%Cor e Forma:Blue-Black Solid From Water Ethanol SolidPeso molecular:517.4A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Fórmula:C12H14Cl2N2O2SPureza:99.32%Cor e Forma:SolidPeso molecular:321.22Delcasertib
CAS:<p>Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).</p>Fórmula:C120H199N45O34S2Pureza:99.96%Cor e Forma:SolidPeso molecular:2880.28PKC β pseudosubstrate acetate
<p>PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.</p>Pureza:95.42%Cor e Forma:SoildProtein kinase C α peptide TFA
CAS:<p>Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.</p>Fórmula:C68H115F3N24O26SCor e Forma:SolidPeso molecular:1773.85Protein Kinase C (19-31)
CAS:<p>Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.</p>Fórmula:C67H118N26O16Pureza:98%Cor e Forma:Lyophilized PowderPeso molecular:1543.82Pep2m, myristoylated
CAS:<p>Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.</p>Fórmula:C63H118N18O14SPureza:98%Cor e Forma:SolidPeso molecular:1383.8[Ala107]MBP(104-118)
CAS:<p>Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).</p>Fórmula:C67H104N20O19Pureza:98%Cor e Forma:SolidPeso molecular:1493.68Delcasertib acetate
<p>Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.</p>Fórmula:C122H203N45O36S2Pureza:98.92%Cor e Forma:SolidPeso molecular:2940.33[Ala113]MBP(104-118)
CAS:<p>Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).</p>Fórmula:C67H104N20O19Pureza:98%Cor e Forma:SolidPeso molecular:1493.68Myelin Basic Protein
CAS:<p>Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.</p>Fórmula:C60H103N21O17Pureza:98%Cor e Forma:SolidPeso molecular:1390.59Psychosine
CAS:<p>Psychosine (Galactosylsphingosine) is a PKC inhibitor, and is highly cytotoxic, inducing cell death in a variety of cells.</p>Fórmula:C24H47NO7Pureza:98%Cor e Forma:White PowderPeso molecular:461.63Aurothiomalate tetramer sodium
<p>Aurothiomalate tetramer sodium, a tetrameric form of Aurothiomalate sodium, functions as an anti-arthritis gold agent. It also acts as a potent and selective inhibitor of the oncogenic PKCι signaling pathway.</p>Cor e Forma:Odour SolidZIP
CAS:<p>Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.</p>Fórmula:C90H154N30O17Pureza:98%Cor e Forma:SolidPeso molecular:1928.4Sangivamycin
CAS:<p>Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.</p>Fórmula:C12H15N5O5Pureza:99.85%Cor e Forma:SolidPeso molecular:309.28K-252b
CAS:<p>K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.</p>Fórmula:C26H19N3O5Pureza:98%Cor e Forma:Ready-To-Use SolutionPeso molecular:453.45Protein Kinase C (19-31) (TFA)(121545-65-1,free)
<p>Protein Kinase C (19-31) TFA is a serine-modified PKCa-derived inhibitor for testing PKC activity.</p>Fórmula:C69H119F3N26O18Pureza:98%Cor e Forma:SolidPeso molecular:1657.84Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Cor e Forma:SolidPeso molecular:291.37NPC-15437 dihydrochloride
CAS:<p>NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.</p>Fórmula:C25H52Cl2N4O2Cor e Forma:SolidPeso molecular:511.62Protein kinase inhibitor H-7
CAS:<p>H-7: potent PKC inhibitor with 6 μM Ki, also blocks cyclic nucleotide-dependent kinases.</p>Fórmula:C14H17N3O2SPureza:99.91%Cor e Forma:SoildPeso molecular:291.37Neuropeptide DF2
CAS:<p>Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.</p>Fórmula:C44H67N15O10Pureza:98%Cor e Forma:SolidPeso molecular:966.1Bisindolylmaleimide III
CAS:<p>Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6</p>Fórmula:C23H20N4O2Pureza:98.6%Cor e Forma:SolidPeso molecular:384.43PKCiota-IN-2
CAS:<p>PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).</p>Fórmula:C24H21N5OPureza:98.86%Cor e Forma:SolidPeso molecular:395.46LY 379196
<p>LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.</p>Fórmula:C30H34N4O5SCor e Forma:SolidPeso molecular:562.68(8R)-8-Hydroxyepoxyboetirane A
<p>(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.</p>Cor e Forma:Odour SolidPKCδ Peptide Substrate
CAS:<p>PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) and</p>Fórmula:C109H191N35O29SCor e Forma:SolidPeso molecular:2487.97Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:<p>Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.</p>Fórmula:C56H110N22O14Pureza:98%Cor e Forma:SolidPeso molecular:1315.61Ac-MBP (1-11)
CAS:<p>Ac-MBP 1-11, a primary encephalitogenic epitope in myelin basic protein (MBP), is a dominant short peptide sequence[1].</p>Fórmula:C2H3K2OPS3Pureza:98%Cor e Forma:SolidPeso molecular:248.411-Oleoyl-2-acetyl-sn-glycerol
CAS:<p>1-Oleoyl-2-acetyl-sn-glycerol (1-oleoyl-2-acetyl-glycerol) is a PKC activator that induces superoxide production.</p>Fórmula:C23H42O5Cor e Forma:SolidPeso molecular:398.58Protein Kinase C (19-36)
CAS:<p>Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.</p>Fórmula:C93H159N35O24Pureza:98%Cor e Forma:SolidPeso molecular:2151.48PKC β pseudosubstrate
CAS:<p>Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).</p>Fórmula:C177H294N62O38S3Pureza:98%Cor e Forma:SolidPeso molecular:3994.84SAMβA TFA
<p>SAMβA TFA, a selective antagonist of Mfn1-βIIPKC association conjugated to the cell permeable peptide TAT47-57, is a rationally designed inhibitor that improves</p>Fórmula:C50H73N17O16·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:1168.22 (free acid)(±)-1,2-Diolein
CAS:<p>(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.</p>Fórmula:C39H72O5Cor e Forma:SolidPeso molecular:620.99PKC-θ inhibitor
CAS:<p>PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.</p>Fórmula:C20H25F3N6O3Pureza:99.46%Cor e Forma:SolidPeso molecular:454.45Protein kinase inhibitor H-7 dihydrochloride
CAS:<p>Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor.</p>Fórmula:C14H19Cl2N3O2SPureza:99.54%Cor e Forma:White Crystalline SolidPeso molecular:364.29Taurochenodeoxycholic Acid
CAS:<p>Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.</p>Fórmula:C26H45NO6SPureza:99.53% - 99.86%Cor e Forma:SolidPeso molecular:499.7HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Fórmula:C13H15N3O2SPureza:99.44%Cor e Forma:Pale Yellow Crystalline SolidPeso molecular:277.34Midostaurin
CAS:<p>PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.</p>Fórmula:C35H30N4O4Pureza:97.61% - >99.99%Cor e Forma:SolidPeso molecular:570.64R59949
CAS:<p>R59949 is used as a Diacylglycerol kinase (DGK) inhibitor.</p>Fórmula:C28H25F2N3OSPureza:97.04%Cor e Forma:SolidPeso molecular:489.58TAS-301
CAS:<p>TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.</p>Fórmula:C23H19NO3Pureza:99.55%Cor e Forma:SolidPeso molecular:357.4Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Cor e Forma:White SolidPeso molecular:327.83Darovasertib
CAS:<p>Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).</p>Fórmula:C22H23F3N8OPureza:98.72% - ≥95%Cor e Forma:SolidPeso molecular:472.47Chelerythrine chloride
CAS:<p>Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to</p>Fórmula:C21H18ClNO4Pureza:95% - 99.19%Cor e Forma:Yellow To Orange SolidPeso molecular:383.83Ζ-Stat
CAS:<p>ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in</p>Fórmula:C10H8O10S3Pureza:99.85%Cor e Forma:SolidPeso molecular:384.36Taurolithocholic acid sodium salt
CAS:<p>Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but</p>Fórmula:C26H44NNaO5SPureza:99.79% - 99.93%Cor e Forma:SolidPeso molecular:505.69Desmethylglycitein
CAS:<p>Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has</p>Fórmula:C15H10O5Pureza:97.93%Cor e Forma:SolidPeso molecular:270.24Go 6983
CAS:<p>Go 6983 is a PKC inhibitor with IC50 values of 7, 7, 6, 10, and 60 nM for PKCα, PKCβ, PKCγ, PKCδ, and PKCζ, respectively. High-Quality, Low-Cost!</p>Fórmula:C26H26N4O3Pureza:98.41% - 99.85%Cor e Forma:SolidPeso molecular:442.51
![[Ala107]MBP(104-118)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1887.webp&w=3840&q=75)
![[Ala113]MBP(104-118)](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1888.webp&w=3840&q=75)
