DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:499.75PARP/EZH2-IN-2
PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.Fórmula:C33H31N7O3Peso molecular:573.24884EPZ-719
CAS:EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.Fórmula:C22H31FN4O3SCor e Forma:SolidPeso molecular:450.57AS-254s
AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.Fórmula:C36H41ClN6O3S2Cor e Forma:SolidPeso molecular:705.332Tet1 peptide
CAS:Tet1peptide is a neuron-specific ligand for GT1B ganglioside. It can serve as a ligand for the targeted delivery of functionalized polymers.Fórmula:C73H114N20O17Cor e Forma:SolidPeso molecular:1543.81Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].Fórmula:C34H43N3O7Cor e Forma:SolidPeso molecular:605.72FTX-6058 hydrochloride
CAS:FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Fórmula:C22H19ClFN5O2Cor e Forma:SolidPeso molecular:439.87PRMT5-IN-14
CAS:PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.Fórmula:C18H18Cl2N4O4Cor e Forma:SolidPeso molecular:425.27PRMT5-IN-9
CAS:<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Fórmula:C25H23F3N6OCor e Forma:SolidPeso molecular:480.495MRTX9768 hydrochloride
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.Cor e Forma:SolidSGC3027
SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.Fórmula:C41H47ClN6O6SPureza:98%Cor e Forma:SolidPeso molecular:787.37Aclantate
CAS:Aclantate is a nonsteroidal anti-inflammatory drug.Fórmula:C15H14ClNO4SPureza:98%Cor e Forma:SolidPeso molecular:339.79CPI-1328
CAS:CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.Fórmula:C28H36ClN3O4SCor e Forma:SolidPeso molecular:546.12MAK683-CH2CH2COOH hydrochloride
MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.Fórmula:C23H22ClFN6O3Cor e Forma:SolidPeso molecular:484.91EEDi-5273
CAS:EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.Fórmula:C26H22F4N6O2Cor e Forma:SolidPeso molecular:526.496PRMT5-IN-41
CAS:PRMT5-IN-41 (compound 130) is an effective orally active inhibitor of PRMT5. It inhibits the hERG ion channel with an IC50 of 1.36 µM.Fórmula:C22H16F5N5O2Peso molecular:477.39PRMT5-IN-4
CAS:PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.Fórmula:C11H13N3O4SCor e Forma:SolidPeso molecular:283.3UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Fórmula:C47H70N6O8Pureza:98%Cor e Forma:SolidPeso molecular:847.09PROTAC EED degrader-2
PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.Fórmula:C50H58FN11O6SPureza:98%Cor e Forma:SolidPeso molecular:960.13PRMT5-IN-12
CAS:PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .Fórmula:C32H40N4O4Cor e Forma:SolidPeso molecular:544.696PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Cor e Forma:Odour SolidXF067-68
CAS:XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Fórmula:C52H59F4N9O7SCor e Forma:SolidPeso molecular:1030.14LLY-284
CAS:LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.Fórmula:C17H18N4O4Pureza:98%Cor e Forma:SolidPeso molecular:342.35MAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Fórmula:C20H18ClFN6OPureza:97.02% - >99.99%Cor e Forma:SolidPeso molecular:412.85EZH2-IN-15
CAS:A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.Fórmula:C32H44N4O4Pureza:99.88%Cor e Forma:SolidPeso molecular:548.72Ref: TM-T67883
1mg143,00€5mg344,00€10mg525,00€25mg833,00€50mg1.121,00€100mg1.510,00€200mg2.023,00€1mL*10mM (DMSO)418,00€Methylation Compound Library
xnum methylation-related compounds that can be used for high-throughput and high-content screening.Cor e Forma:Odour SolidRef: TM-L3510
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarDC-S239
CAS:Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Fórmula:C15H15N3O5SPureza:99.37%Cor e Forma:SolidPeso molecular:349.36Ref: TM-T60002
2mg46,00€5mg70,00€10mg101,00€25mg197,00€50mg320,00€100mg509,00€200mg695,00€1mL*10mM (DMSO)77,00€PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Fórmula:C55H60FN11O8SPureza:98%Cor e Forma:SolidPeso molecular:1054.2EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Fórmula:C26H37BrN4O2Cor e Forma:SolidPeso molecular:517.512E67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Fórmula:C21H36N6O2Cor e Forma:SolidPeso molecular:404.559DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Cor e Forma:Odour SolidSW2_110A
CAS:SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.Fórmula:C42H60N6O7Pureza:98%Cor e Forma:SolidPeso molecular:760.96Dot1L-IN-1 TFA
Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).Fórmula:C34H37ClF3N9O4SCor e Forma:SolidPeso molecular:760.23GSK 591 dihydrochloride
CAS:Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.Fórmula:C22H30Cl2N4O2Cor e Forma:SolidPeso molecular:453.41WDR5-MYC-IN-1
WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.Cor e Forma:Odour SolidEPZ-025654
CAS:EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.Fórmula:C29H33ClN8O3Cor e Forma:SolidPeso molecular:577.08DDO-2093
CAS:DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.Fórmula:C29H37ClFN9O3Cor e Forma:SolidPeso molecular:614.12C 21
CAS:PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Fórmula:C90H161ClN36O24Pureza:98%Cor e Forma:SolidPeso molecular:2166.94MS9024
MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.Cor e Forma:Odour SolidCARM1/IKZF3 ligand 1
CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.Fórmula:C27H35ClN6O3Cor e Forma:SolidPeso molecular:527.06PRMT5 ligand 1
CAS:PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.Fórmula:C20H26N6O2Cor e Forma:SolidPeso molecular:382.459PRMT5-IN-11
CAS:PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.Fórmula:C13H17N5O4Cor e Forma:SolidPeso molecular:307.31PARP/EZH2-IN-1
CAS:PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.Fórmula:C43H41FN8O5Cor e Forma:SolidPeso molecular:768.85MRK-990
MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.Cor e Forma:Odour SolidML234
ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.Cor e Forma:Odour SolidMS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Fórmula:C28H42ClN5O3Pureza:98.9% - 98.96%Cor e Forma:SolidPeso molecular:532.12SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Fórmula:C45H62Cl3N7O8Cor e Forma:SolidPeso molecular:935.37BBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Fórmula:C37H47N5O5SCor e Forma:SolidPeso molecular:673.32979FTX-6058
CAS:FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Fórmula:C22H18FN5O2Cor e Forma:SolidPeso molecular:403.417
