DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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5WKS
CAS:5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.Fórmula:C24H36ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:462.03RSC-133
CAS:promotes the reprogramming of human somatic cells to pluripotent stem cellsFórmula:C18H15N3O2Pureza:98%Cor e Forma:SolidPeso molecular:305.33WDR5-IN-4
CAS:WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.Fórmula:C25H22Cl2FN5OPureza:98%Cor e Forma:SolidPeso molecular:498.38OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Fórmula:C25H26ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:463.96Guadecitabine sodium
CAS:Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .Fórmula:C18H24N9NaO10PPureza:98%Cor e Forma:SolidPeso molecular:580.407TFMB-(S)-2-HG
CAS:TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.Fórmula:C13H11F3O4Pureza:98.07%Cor e Forma:SolidPeso molecular:288.22Ref: TM-T24871
2mg35,00€5mg52,00€10mg84,00€25mg155,00€50mg240,00€100mg358,00€500mg753,00€1mL*10mM (DMSO)51,00€UNC2327
CAS:UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).Fórmula:C14H17N5O2SPureza:98%Cor e Forma:SolidPeso molecular:319.38Arazine
CAS:Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.Fórmula:C20H33NO3SPureza:90%Cor e Forma:SolidPeso molecular:367.55SKF 91488 dihydrochloride
CAS:histamine N-methyltransferase inhibitorFórmula:C7H19Cl2N3SPureza:98%Cor e Forma:SolidPeso molecular:248.22D 595
CAS:D595 is a phenethylamine-type calcium channel blocker. The most potent phenylethylamine with respect to negative inotropy was D595 (EC50: 794 nmol/l).Fórmula:C25H32Cl2N2O2Pureza:98%Cor e Forma:SolidPeso molecular:463.44GSK926
CAS:GSK926 is a selective, SAM-competitive, and cell-active EZH2 inhibitor.Fórmula:C29H35N7O2Cor e Forma:SolidPeso molecular:513.63PRMT5-IN-2
CAS:PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.Fórmula:C17H16ClFN4O4Pureza:98%Cor e Forma:SolidPeso molecular:394.78PDAT
CAS:PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.Fórmula:C15H23N3Pureza:98%Cor e Forma:SolidPeso molecular:245.36Guadecitabine
CAS:Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.Fórmula:C18H24N9O10PPureza:98%Cor e Forma:SolidPeso molecular:557.41DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Fórmula:C29H39Cl3FN9O3Cor e Forma:SolidPeso molecular:687.04Furamidine
CAS:Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.Fórmula:C18H16N4OPureza:98%Cor e Forma:SolidPeso molecular:304.35(R)-OR-S1
CAS:(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.Fórmula:C26H34BrN3O4Pureza:98%Cor e Forma:SolidPeso molecular:532.47UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Fórmula:C25H36F3N5O4Cor e Forma:SolidPeso molecular:527.589SGC6870
CAS:SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.Fórmula:C23H21BrN2O2SCor e Forma:SolidPeso molecular:469.39EZM 2302
CAS:EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.Fórmula:C29H37ClN6O5Pureza:97.47% - ≥98%Cor e Forma:SolidPeso molecular:585.09ZLD1039
CAS:ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.Fórmula:C36H48N6O3Pureza:99.5%Cor e Forma:SolidPeso molecular:612.8CMP-5 hydrochloride
CAS:CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.Fórmula:C21H22ClN3Pureza:98%Cor e Forma:SolidPeso molecular:351.87Dot1L-IN-2
CAS:Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectivelyFórmula:C27H24N8OPureza:98%Cor e Forma:SolidPeso molecular:476.53BIX-01338 hydrate
CAS:BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.Fórmula:C32H26F3N3O7Pureza:98%Cor e Forma:SolidPeso molecular:621.56GNA002
CAS:GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Fórmula:C42H55NO8Pureza:98%Cor e Forma:SolidPeso molecular:701.89CM-579
CAS:CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.Fórmula:C29H40N4O3Pureza:99.23%Cor e Forma:SolidPeso molecular:492.65Ref: TM-T10840L
1mg52,00€5mg90,00€10mg131,00€25mg207,00€50mg303,00€100mg447,00€1mL*10mM (DMSO)117,00€MM-102
CAS:MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay.Cost-effective and quality-assured.Fórmula:C35H49F2N7O4Pureza:98.77% - 99.99%Cor e Forma:SolidPeso molecular:669.8Ref: TM-T6333
1mg39,00€2mg51,00€5mg105,00€10mg168,00€25mg351,00€50mg543,00€100mg777,00€1mL*10mM (DMSO)156,00€Furamidine dihydrochloride
CAS:Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.Fórmula:C18H18Cl2N4OPureza:98.16%Cor e Forma:SolidPeso molecular:377.27NSC-311068
CAS:NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.Fórmula:C10H6N4O4SCor e Forma:SolidPeso molecular:278.24SW155246
CAS:SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).Fórmula:C16H11ClN2O5SPureza:98.99%Cor e Forma:SolidPeso molecular:378.79EPZ032597
CAS:EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFórmula:C20H23N7OPureza:99.70%Cor e Forma:SolidPeso molecular:377.44EZH2-IN-11
CAS:EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.Fórmula:C28H36ClN3O5SCor e Forma:SolidPeso molecular:562.12PRMT4-IN-1
CAS:PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].Fórmula:C23H28FN3OPureza:98%Cor e Forma:SolidPeso molecular:381.49EZH2-IN-3
CAS:EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.Fórmula:C27H28ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:490EZH2-IN-9
CAS:EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.Fórmula:C28H32ClF2N3O5SCor e Forma:SolidPeso molecular:596.09AA-CW236
CAS:AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).Fórmula:C17H16ClF3N4O2Cor e Forma:SolidPeso molecular:400.78DS-437
CAS:DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.Fórmula:C15H23N7O4SPureza:98%Cor e Forma:SolidPeso molecular:397.45SMYD2-IN-1
CAS:SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).Fórmula:C25H25Cl2F2N7O2Pureza:98%Cor e Forma:SolidPeso molecular:564.41PRMT5:MEP50 PPI
PRMT5:MEP50 PPI inhibitor with anti-tumor and anti-proliferative effects on lung and prostate cancers.Fórmula:C24H22N4O4Cor e Forma:SolidPeso molecular:430.46Dot1L-IN-7
CAS:Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.Fórmula:C23H27N9O2Cor e Forma:SolidPeso molecular:461.526-Methyl-5-azacytidine
CAS:6-Methyl-5-azacytidine is a potent DNMT inhibitor.Fórmula:C9H14N4O5Pureza:98%Cor e Forma:SolidPeso molecular:258.23Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Fórmula:C9H16N2O6Pureza:98%Cor e Forma:SolidPeso molecular:248.23DC_517
CAS:DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).Fórmula:C33H35N3O2Cor e Forma:SolidPeso molecular:505.65PRMT5-IN-10
CAS:PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.Fórmula:C13H17N5O4Cor e Forma:SolidPeso molecular:307.31NSD3-IN-1
CAS:NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.Fórmula:C13H13N5OSCor e Forma:SolidPeso molecular:287.34EML741
CAS:<p>EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.</p>Fórmula:C31H49N5O2Pureza:98%Cor e Forma:SolidPeso molecular:523.75DCE_42
CAS:DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.Fórmula:C22H19N9O2SPureza:98%Cor e Forma:SolidPeso molecular:473.51BI-9321
CAS:BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.Fórmula:C22H21FN4Pureza:98%Cor e Forma:SolidPeso molecular:360.43CARM1-IN-1
CAS:CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.Fórmula:C26H21Br2NO3Pureza:98.24%Cor e Forma:SolidPeso molecular:555.26Ref: TM-T10682L
1mg37,00€5mg88,00€10mg127,00€25mg250,00€50mg406,00€100mg632,00€200mg883,00€1mL*10mM (DMSO)97,00€MS0124
CAS:<p>MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.</p>Fórmula:C20H29N5O3Pureza:98.97%Cor e Forma:SolidPeso molecular:387.48
