DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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CPUY074020
CAS:CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.Fórmula:C25H28N4O2Pureza:98.64%Cor e Forma:SolidPeso molecular:416.52Ref: TM-T10882
1mg74,00€5mg156,00€10mg215,00€25mg338,00€50mg475,00€100mg620,00€200mg848,00€1mL*10mM (DMSO)168,00€TM2-115
CAS:TM2-115 is a inhibitor of malaria parasite histone methyltransferases that results in rapid and irreversible parasite death [1].Fórmula:C28H38N6O2Pureza:97.67%Cor e Forma:SolidPeso molecular:490.64Procainamide
CAS:Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.Fórmula:C13H21N3OPureza:99.79% - 99.92%Cor e Forma:SolidPeso molecular:235.33LEM-14
CAS:<p>LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.</p>Fórmula:C25H26N4O4SPureza:98.3%Cor e Forma:SolidPeso molecular:478.56Cedazuridine
CAS:Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.Fórmula:C9H14F2N2O5Pureza:99.66%Cor e Forma:SolidPeso molecular:268.21UNC0321
CAS:UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Fórmula:C27H45N7O3Pureza:99.80%Cor e Forma:SolidPeso molecular:515.69EZH2-IN-13
CAS:EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.Fórmula:C34H45N5O3Pureza:98.3%Cor e Forma:SolidPeso molecular:571.75Bobcat339 hydrochloride
CAS:Bobcat339 hydrochloride is a 10 11 translocation (TET) dioxygenase inhibitor that inhibits both TET1 and TET2.Fórmula:C16H13Cl2N3OPureza:99.22%Cor e Forma:SolidPeso molecular:334.2Ref: TM-T61012
2mg35,00€5mg52,00€10mg85,00€25mg160,00€50mg250,00€100mg373,00€200mg547,00€1mL*10mM (DMSO)58,00€DW14800
CAS:DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Fórmula:C31H36N4O3Pureza:99.55% - 99.68%Cor e Forma:SolidPeso molecular:512.64Ref: TM-T11131
1mg87,00€2mg130,00€5mg216,00€10mg378,00€25mg717,00€50mg948,00€100mg1.415,00€1mL*10mM (DMSO)245,00€WDR5-0102
CAS:<p>WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.</p>Fórmula:C18H19ClN4O3Pureza:98.03%Cor e Forma:SolidPeso molecular:374.82TNG908
CAS:TNG908, a brain-penetrant PRMT5 inhibitor, is 15x more selective for MTAP mutant vs WT lines, useful in cancer studies.Fórmula:C21H23N5O2SPureza:98.08% - 98.24%Cor e Forma:SolidPeso molecular:409.51Ref: TM-T73494
1mg70,00€5mg154,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€1mL*10mM (DMSO)166,00€WM-586
CAS:WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.Fórmula:C20H20F3N5O3SPureza:98%Cor e Forma:SolidPeso molecular:467.47Bisegliptin
CAS:Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.Fórmula:C18H26FN3O3Pureza:98%Cor e Forma:SolidPeso molecular:351.42MS67
CAS:MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.Fórmula:C52H59F4N9O7SCor e Forma:SolidPeso molecular:1030.14Compound SA91-0178
CAS:SA91-0178 (3-{[(1-methyl-2-oxo-1'-phenyl-1,2-dihydrospiro[indole-3,4'-piperidine]-5-carbonyl)amino]methyl}benzoic acid) is a specific METTL1 inhibitor and effectively alleviated tissue injury during septic inflammation.Fórmula:C28H27N3O4Peso molecular:469.54GSK3368715 hydrochloride
CAS:GSK3368715, a first-in-class, orally active, potent, and selective SAM-noncompetitive inhibitor of Type I Protein Arginine Methyltransferases (PRMTs), exhibits anti-tumor efficacy across multiple cancer models and alters exon usage with IC50 values in the lower nM range. It synergizes with GSK3326595 (Type II inhibitor) (Axon 3750) to inhibit tumor growth.Fórmula:C20H38N4O2·HClCor e Forma:SolidPeso molecular:403UNC7145
CAS:UNC6934 Negative Control (Axon 3591) is a chemically related compound that serves as a negative control for UNC6934, a potent and selective chemical probe that specifically targets the N-terminal PWWP (PWWP1) domain of NSD2.Fórmula:C24H23N5O4Cor e Forma:SolidPeso molecular:445.4705MTDH-SND1 blocker 1
CAS:MTDH-SND1 Blocker 1 (Compound C26-A6) serves as an inhibitor targeting the MTDH-SND1 protein, effectively suppressing cancer metastasis [1].Fórmula:C14H13ClN4O3SCor e Forma:SolidPeso molecular:352.8GSK-2807 free base
CAS:GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Fórmula:C19H32N8O5Cor e Forma:SolidPeso molecular:452.51CM-579 trihydrochloride (1846570-40-8 free base)
CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wideFórmula:C29H43Cl3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:602.04SMYD3-IN-1
CAS:SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).Fórmula:C28H31ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:507.02MAK683-CH2CH2COOH
CAS:MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.Fórmula:C23H21FN6O3Pureza:98%Cor e Forma:SolidPeso molecular:448.45GSK-3484862
CAS:Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.Fórmula:C19H19N5OSPureza:99.87% - 99.963%Cor e Forma:SolidPeso molecular:365.45Ref: TM-T11469
1mg48,00€5mg113,00€10mg177,00€25mg318,00€50mg485,00€100mg692,00€500mg1.395,00€1mL*10mM (DMSO)203,00€UNC8153 TFA
CAS:UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating aFórmula:C35H38F3N5O7Pureza:96.44%Cor e Forma:SolidPeso molecular:697.7CARM1-IN-3
CAS:CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFórmula:C24H32N4O2Pureza:98%Cor e Forma:SolidPeso molecular:408.54PRMT5-IN-28
CAS:PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processesFórmula:C18H19ClN4O5Pureza:98%Cor e Forma:SolidPeso molecular:406.82PRMT5-IN-29
CAS:PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].Fórmula:C18H20Cl3N5O5Pureza:98%Cor e Forma:SolidPeso molecular:492.74PRMT5-IN-25
CAS:PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1Fórmula:C24H21F3N6OPureza:98%Cor e Forma:SolidPeso molecular:466.46EPZ011989 HCl(1598383-40-4 Free base)
CAS:EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.Fórmula:C35H51N5O4·HClCor e Forma:SolidPeso molecular:642.27DY-46-2
CAS:DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Fórmula:C19H22N6O5SPureza:99.12% - 99.12%Cor e Forma:SolidPeso molecular:446.48RK-701
CAS:RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.Fórmula:C26H30N4O3Cor e Forma:SolidPeso molecular:446.54DNMT-IN-3
CAS:DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].Fórmula:C37H39N7OCor e Forma:SolidPeso molecular:597.75RK-0133114
RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.Fórmula:C26H30N4O3Cor e Forma:SolidPeso molecular:446.54EZH2-IN-14
CAS:EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.Fórmula:C31H39N7O2Cor e Forma:SolidPeso molecular:541.69MS023 trihydrochloride
CAS:MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.Fórmula:C17H28Cl3N3OPureza:99.81%Cor e Forma:SolidPeso molecular:396.78PRT543
CAS:PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.Fórmula:C17H17ClN4O4Cor e Forma:SolidPeso molecular:376.79PRMT5-IN-16
CAS:PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.Fórmula:C25H34N8O2Cor e Forma:SolidPeso molecular:478.59EPZ-030456
CAS:EPZ-030456 is an effective and selective inhibitor of the SMYD3.Fórmula:C28H34ClN5O4SCor e Forma:SolidPeso molecular:572.12GSK-A
CAS:GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.Fórmula:C21H25N5O2Cor e Forma:SolidPeso molecular:379.46EPZ031686
CAS:<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>Fórmula:C26H34ClF3N4O4SPureza:99.67%Cor e Forma:SolidPeso molecular:591.09MS117
MS117 is a first-in-class and cell-active irreversible covalent inhibitor of protein arginine methyltransferase 6 (PRMT6) (IC50 = 18 nM) [1].Fórmula:C17H22N4OCor e Forma:SolidPeso molecular:298.38PRMT5-MTA-IN-3
CAS:PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.Fórmula:C19H17F3N6O3Cor e Forma:SolidPeso molecular:434.372PRMT5-IN-3
CAS:PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.Fórmula:C22H23F3N4O3Cor e Forma:SolidPeso molecular:448.44RU-0415529
CAS:RU-0415529 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (NSP14), with an IC50 of 356 nM. It inhibits viral RNA methylation and replication by stabilizing the cap-binding pocket through SAH binding. Additionally, RU-0415529 exhibits anti-infective activity in mouse models.Fórmula:C21H29N3O4SCor e Forma:SolidPeso molecular:419.538GSK3368715
CAS:GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50sFórmula:C20H38N4O2Pureza:98%Cor e Forma:SolidPeso molecular:366.54MS8815
CAS:MS8815 is a selective EZH2 PROTAC degrader with IC50 of 8.6 nM, used in triple-negative breast cancer research.Fórmula:C65H87N9O8SCor e Forma:SolidPeso molecular:1154.51SARS-CoV-2 nsp14-IN-1
SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.Fórmula:C20H20N6O5SCor e Forma:SolidPeso molecular:456.48PF-06726304 acetate
CAS:PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.Fórmula:C24H25Cl2N3O5Pureza:98%Cor e Forma:SolidPeso molecular:506.38TDI-015051
CAS:TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.Fórmula:C22H22FN5O4SCor e Forma:SolidPeso molecular:471.505(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Fórmula:C19H14N2O4Cor e Forma:SolidPeso molecular:334.326
