Sirtuína
As sirtuínas são uma família de desacetilases dependentes de NAD+ que desempenham um papel crucial na regulação de processos celulares como reparo de DNA, envelhecimento, metabolismo e resistência ao estresse. As sirtuínas influenciam o reparo do DNA ao desacetilar proteínas envolvidas nas vias de reparo, modulando assim sua atividade. Inibidores e ativadores de sirtuínas são ferramentas valiosas em pesquisas sobre envelhecimento, câncer e doenças metabólicas, onde a regulação do reparo do DNA e da longevidade celular é de interesse. Na CymitQuimica, oferecemos uma gama de moduladores de sirtuínas de alta qualidade para apoiar sua pesquisa em reparo de DNA, envelhecimento celular e regulação metabólica.
Foram encontrados 88 produtos de "Sirtuína"
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Nicotinamide riboside
CAS:<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>Fórmula:C11H15N2O5Pureza:98.82% - 99.58%Cor e Forma:SolidPeso molecular:255.25Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Fórmula:C14H12O3Pureza:99.82% - 99.96%Cor e Forma:Off-White To Tan PowderPeso molecular:228.24MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Fórmula:C33H38N4O8Pureza:98% - 99.90%Cor e Forma:SoildPeso molecular:618.68Ref: TM-T11962
1mg52,00€2mg74,00€5mg111,00€10mg180,00€25mg283,00€50mg445,00€100mg723,00€500mg1.454,00€SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Fórmula:C15H21N5O3S2Pureza:98.26%Cor e Forma:SolidPeso molecular:383.49Ref: TM-T12919
1mg97,00€5mg227,00€10mg364,00€25mg620,00€50mg848,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)250,00€SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Fórmula:C24H29ClN8O4SPureza:98.68%Cor e Forma:SolidPeso molecular:561.06Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Fórmula:C17H15FN2OPureza:99.54%Cor e Forma:SolidPeso molecular:282.31Ref: TM-T77653
1mg57,00€2mg81,00€5mg120,00€10mg180,00€25mg329,00€50mg472,00€100mg700,00€500mg1.406,00€Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Fórmula:C34H46N6O6SPureza:99.52%Cor e Forma:SolidPeso molecular:666.83SIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Cor e Forma:Odour SolidSIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Fórmula:C14H16N2OPureza:99.58%Cor e Forma:SolidPeso molecular:228.29SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Fórmula:C22H25ClN8O2SPureza:99.56%Cor e Forma:SolidPeso molecular:501SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Pureza:98%Cor e Forma:Odour SolidSIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Fórmula:C55H91N9O15SCor e Forma:SolidPeso molecular:1150.43BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFórmula:C24H25NO4Pureza:99.98%Cor e Forma:SolidPeso molecular:391.46SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Fórmula:C22H24N2O9SCor e Forma:SolidPeso molecular:492.5SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Cor e Forma:Odour SolidBenzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Fórmula:C20H15N3O2SPureza:99.32%Cor e Forma:SolidPeso molecular:361.42SIRT2-IN-17
SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.Fórmula:C24H15N3O2SCor e Forma:SolidPeso molecular:409.46MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Fórmula:C22H19N3OSPureza:99.9%Cor e Forma:SolidPeso molecular:373.47Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Fórmula:C19H15N3O2SPureza:99.67%Cor e Forma:SolidPeso molecular:349.41Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Fórmula:C21H20N4O3S2Pureza:98%Cor e Forma:SolidPeso molecular:440.54WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Fórmula:C25H21N5O2SPureza:99.33%Cor e Forma:SolidPeso molecular:455.53SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Fórmula:C22H12FN3O4Pureza:98%Cor e Forma:SolidPeso molecular:401.35ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Fórmula:C26H29I2NO3Pureza:99.23%Cor e Forma:SolidPeso molecular:657.32Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Fórmula:C34H51N3O3SPureza:99.16%Cor e Forma:SolidPeso molecular:581.85Ref: TM-T3447
1mg57,00€2mg77,00€5mg96,00€10mg124,00€25mg227,00€50mg380,00€100mg567,00€1mL*10mM (DMSO)124,00€Selisistat S-enantiomer
CAS:<p>Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.</p>Fórmula:C13H13ClN2OPureza:99.86%Cor e Forma:SolidPeso molecular:248.71Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Fórmula:C51H34N6Na6O23S6Pureza:97.47% - 99.97%Cor e Forma:WhitePeso molecular:1429.15Ref: TM-T2160
1mg42,00€5mg90,00€10mg120,00€25mg202,00€50mg300,00€100mg429,00€200mg620,00€1mL*10mM (DMSO)106,00€CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Fórmula:C22H15FN4O2SPureza:98.92%Cor e Forma:SolidPeso molecular:418.44Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Fórmula:C11H15ClN2O5Pureza:98.92% - 99.86%Cor e Forma:SolidPeso molecular:290.7Ref: TM-T6220
1g92,00€5gA consultar10gA consultar50mg37,00€100mg52,00€500mg78,00€1mL*10mM (DMSO)47,00€AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Fórmula:C19H21N3O5SPureza:98.32% - 99.44%Cor e Forma:SolidPeso molecular:403.45E1231
CAS:E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.Fórmula:C21H21N3O3Pureza:98.45%Cor e Forma:SolidPeso molecular:363.41Ref: TM-T9106
1mg35,00€5mg73,00€10mg104,00€25mg207,00€50mg329,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)89,00€YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFórmula:C19H21BO7Pureza:99.47%Cor e Forma:SolidPeso molecular:372.18Ref: TM-T9320
2mg40,00€5mg60,00€10mg87,00€25mg180,00€50mg305,00€100mg535,00€200mg690,00€500mg1.074,00€1mL*10mM (DMSO)66,00€Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Fórmula:C16H18O9Pureza:98.97% - ≥95%Cor e Forma:SolidPeso molecular:354.31Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Fórmula:C37H46O12Pureza:99.06% - ≥95%Cor e Forma:SolidPeso molecular:682.753-TYP
CAS:<p>3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.</p>Fórmula:C7H6N4Pureza:99.16% - >99.99%Cor e Forma:SolidPeso molecular:146.15Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Fórmula:C20H23N3O2SPureza:99.33%Cor e Forma:SolidPeso molecular:369.48Dihydrocoumarin
CAS:Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).Fórmula:C9H8O2Pureza:98.46%Cor e Forma:Leaflets Room Temperature (Ntp 1992)Peso molecular:148.16Gardenia yellow
CAS:Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.Fórmula:C44H64O24Pureza:98.24% - 98.82%Cor e Forma:Orange Yellow To Reddish Yellow PowderPeso molecular:976.96Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Fórmula:C25H34N4O2SPureza:98.89% - >99.99%Cor e Forma:SolidPeso molecular:454.63Ref: TM-T1818
1mg43,00€2mg56,00€5mg77,00€10mg87,00€25mg157,00€50mg230,00€100mg393,00€500mg930,00€1mL*10mM (DMSO)79,00€Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Fórmula:C13H13ClN2OPureza:98.53% - 99.94%Cor e Forma:SolidPeso molecular:248.71Ref: TM-T6111
5mg50,00€10mg57,00€25mg93,00€50mg140,00€100mg235,00€200mg349,00€500mg565,00€1mL*10mM (DMSO)52,00€SRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Fórmula:C25H24ClN7OSPureza:98% - 99.93%Cor e Forma:SolidPeso molecular:506.22Ref: TM-T2412
1mg69,00€2mg89,00€5mg139,00€10mg250,00€25mg394,00€50mg562,00€100mg800,00€200mg1.103,00€500mg1.634,00€1mL*10mM (DMSO)221,00€SRT 1720 dihydrochloride
CAS:SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Fórmula:C25H25Cl2N7OSPureza:98.58%Cor e Forma:SolidPeso molecular:542.48Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Fórmula:C20H24O11Pureza:99.71% - 99.98%Cor e Forma:White PowderPeso molecular:440.40SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Fórmula:C22H20N4OS2Pureza:99.52% - 99.75%Cor e Forma:SolidPeso molecular:420.55Ref: TM-T6984
1mg39,00€2mg50,00€5mg79,00€10mg107,00€25mg197,00€50mg311,00€100mg505,00€1mL*10mM (DMSO)90,00€Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Fórmula:C30H42O7Pureza:98.06% - 99.98%Cor e Forma:SolidPeso molecular:514.65AGK2
CAS:<p>AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.</p>Fórmula:C23H13Cl2N3O2Pureza:98.68% - 99.17%Cor e Forma:SolidPeso molecular:434.27Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Fórmula:C26H22N2O2Pureza:97.09% - 99.55%Cor e Forma:SolidPeso molecular:394.47Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Fórmula:C25H19N5OS2Pureza:98% - 99.36%Cor e Forma:SolidPeso molecular:469.58UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Fórmula:C16H13N3Pureza:98.31%Cor e Forma:SolidPeso molecular:247.29Ref: TM-T7679
1mg40,00€5mg81,00€10mg116,00€25mg226,00€50mg324,00€100mg452,00€200mg632,00€1mL*10mM (DMSO)100,00€SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Fórmula:C25H23N7OSPureza:98.84%Cor e Forma:SolidPeso molecular:469.56Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Fórmula:C13H13ClN2OPureza:99.8%Cor e Forma:SolidPeso molecular:248.71Ref: TM-T15263
1mg106,00€2mg159,00€5mg259,00€10mg376,00€25mg630,00€50mg880,00€100mg1.169,00€1mL*10mM (DMSO)284,00€Ophiopogonin D'
CAS:<p>Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.</p>Fórmula:C44H70O16Pureza:99.77%Cor e Forma:SolidPeso molecular:855.02SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Fórmula:C26H24N6O2S2Pureza:98.34% - 99.82%Cor e Forma:SolidPeso molecular:516.64Ref: TM-T6679
1g1.644,00€1mg46,00€5mg87,00€10mg131,00€25mg230,00€50mg378,00€100mg563,00€200mg805,00€500mg1.225,00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Fórmula:C19H14N2O6Pureza:97.47% - 98.6%Cor e Forma:SolidPeso molecular:366.32Ref: TM-T4328
1mg46,00€5mg93,00€10mg117,00€25mg235,00€50mg354,00€100mg530,00€200mg795,00€1mL*10mM (DMSO)93,00€AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Fórmula:C23H13Cl2N3O2Pureza:98.31%Cor e Forma:SolidPeso molecular:434.27SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Fórmula:C27H24N4O2SPureza:97.86%Cor e Forma:SolidPeso molecular:468.57Ref: TM-T16932
1mg50,00€2mg72,00€5mg107,00€10mg165,00€25mg283,00€50mg430,00€100mg622,00€1mL*10mM (DMSO)111,00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Fórmula:C19H21BrN2O3SPureza:98.43% - 99.34%Cor e Forma:SolidPeso molecular:437.35Ref: TM-T5490
1mg37,00€2mg49,00€5mg74,00€10mg105,00€25mg187,00€50mg329,00€100mg540,00€1mL*10mM (DMSO)94,00€Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Fórmula:C15H10O6Pureza:94.14% - 99.05%Cor e Forma:Yellow To Brown Crystalline PowderPeso molecular:286.244'-bromo-Resveratrol
CAS:<p>4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)</p>Fórmula:C14H11BrO2Pureza:99.00%Cor e Forma:SolidPeso molecular:291.14SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Fórmula:C15H12ClN3OPureza:99.79%Cor e Forma:SolidPeso molecular:285.73Ref: TM-T39233
1mg96,00€5mg235,00€10mg354,00€25mg597,00€50mg852,00€100mg1.159,00€1mL*10mM (DMSO)259,00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Fórmula:C25H35ClN4O2SPureza:99.36%Cor e Forma:SolidPeso molecular:491.09Ref: TM-T8480
1mg39,00€2mg51,00€5mg70,00€10mg88,00€25mg140,00€50mg226,00€100mg376,00€1mL*10mM (DMSO)73,00€SRT 1460
CAS:<p>SRT 1460 is a SIRT1 activator.</p>Fórmula:C26H29N5O4SPureza:98.25%Cor e Forma:SolidPeso molecular:507.6Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Fórmula:C21H16N2O2SPureza:98.02% - 99.83%Cor e Forma:SolidPeso molecular:360.43Ref: TM-T4019
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)66,00€Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Fórmula:C26H22N2O2Pureza:97.12% - 99.96%Cor e Forma:SolidPeso molecular:394.47Ref: TM-T6671
2mg43,00€5mg58,00€10mg93,00€25mg178,00€50mg343,00€100mg509,00€500mg1.121,00€1mL*10mM (DMSO)58,00€B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFórmula:C20H17ClN4O3Pureza:99.66%Cor e Forma:SolidPeso molecular:396.83MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Fórmula:C21H16BrCl2FN2O6S2Pureza:99.95% - 99.96%Cor e Forma:SolidPeso molecular:626.3SIRT5 inhibitor 5
CAS:SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Fórmula:C21H14ClN3O3SPureza:99.33%Cor e Forma:SolidPeso molecular:423.87SIRT5 inhibitor 2
CAS:SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Fórmula:C18H12Cl2N2O3SPureza:99.38% - 99.87%Cor e Forma:SolidPeso molecular:407.27SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Fórmula:C21H22N6OS2Pureza:97.6%Cor e Forma:SolidPeso molecular:438.57SIRT5 inhibitor 6
CAS:SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Fórmula:C21H28N6O4SPureza:99.84%Cor e Forma:SolidPeso molecular:460.55Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Fórmula:C28H27N7O2S2Pureza:99.57% - 99.84%Cor e Forma:SolidPeso molecular:557.69Ref: TM-T12920
1mg105,00€5mg215,00€10mg340,00€25mg542,00€50mg735,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)266,00€SIRT5 inhibitor 4
CAS:SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Fórmula:C18H15N3O4SPureza:99.97%Cor e Forma:SolidPeso molecular:369.39SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Fórmula:C31H39FN6O6S2Pureza:97.8%Cor e Forma:SolidPeso molecular:674.81Ref: TM-T12921
1mg145,00€2mg207,00€5mg354,00€10mg530,00€25mg934,00€50mg1.359,00€100mg1.825,00€1mL*10mM (DMSO)465,00€SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Fórmula:C19H14N2O6Pureza:98.77%Cor e Forma:SolidPeso molecular:366.32Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Fórmula:C31H32ClN5O2S2Pureza:99.63%Cor e Forma:SolidPeso molecular:606.2WAY-354574
CAS:WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].Fórmula:C20H23ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:406.93Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Fórmula:C20H17N3O2Pureza:99.1%Cor e Forma:SolidPeso molecular:331.37Epigenetic factor-IN-1
CAS:<p>Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.</p>Fórmula:C32H34FN5O6S2Pureza:98%Cor e Forma:SolidPeso molecular:667.77SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Fórmula:C40H54N8O6SPureza:98%Cor e Forma:SolidPeso molecular:774.97SIRT5 inhibitor 7
CAS:SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.Fórmula:C28H32ClN7O3SPureza:99.77%Cor e Forma:SolidPeso molecular:582.12SIRT-IN-1
CAS:<p>SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).</p>Fórmula:C19H27N5O2SPureza:99.29%Cor e Forma:SolidPeso molecular:389.52SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFórmula:C21H30Br3ClN6SPureza:98%Cor e Forma:SolidPeso molecular:673.73SIRT-IN-6
CAS:<p>SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.</p>Fórmula:C7H4ClN3OSCor e Forma:SolidPeso molecular:213.644SIRT1-IN-5
CAS:SIRT1-IN-5 (215) is a modulator of NAD-dependent deacetylase SIRT1 with potential applications in cancer and cellular signaling research.Fórmula:C21H17N3O3SPureza:99.97%Cor e Forma:SolidPeso molecular:391.44MC3138
CAS:MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Fórmula:C25H25NO6Pureza:99.57%Cor e Forma:SolidPeso molecular:435.47Ref: TM-T88662
1mg52,00€5mg100,00€10mg156,00€25mg302,00€50mg492,00€100mg749,00€200mg999,00€1mL*10mM (DMSO)105,00€Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Fórmula:C28H46N8O6SCor e Forma:SolidPeso molecular:622.78SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Fórmula:C23H23N3O6Cor e Forma:SolidPeso molecular:437.45DCHC
CAS:DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.Fórmula:C15H8Cl2O3Cor e Forma:SolidPeso molecular:307.128MDL-811
CAS:<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Fórmula:C25H25BrCl2FN3O5S2Pureza:98%Cor e Forma:SolidPeso molecular:681.42
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