Sirtuína
As sirtuínas são uma família de desacetilases dependentes de NAD+ que desempenham um papel crucial na regulação de processos celulares como reparo de DNA, envelhecimento, metabolismo e resistência ao estresse. As sirtuínas influenciam o reparo do DNA ao desacetilar proteínas envolvidas nas vias de reparo, modulando assim sua atividade. Inibidores e ativadores de sirtuínas são ferramentas valiosas em pesquisas sobre envelhecimento, câncer e doenças metabólicas, onde a regulação do reparo do DNA e da longevidade celular é de interesse. Na CymitQuimica, oferecemos uma gama de moduladores de sirtuínas de alta qualidade para apoiar sua pesquisa em reparo de DNA, envelhecimento celular e regulação metabólica.
Foram encontrados 91 produtos para "Sirtuína".
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MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Fórmula:C33H38N4O8Pureza:98% - 99.90%Cor e Forma:Yellow SolidPeso molecular:618.68Ref: TM-T11962
1mg50,00€2mg71,00€5mg105,00€10mg170,00€25mg268,00€50mg423,00€100mg685,00€500mg1.378,00€Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-Fórmula:C11H15N2O5Pureza:99.58% - 99.89%Cor e Forma:White SolidPeso molecular:255.25Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Fórmula:C14H12O3Pureza:99.82% - 99.96%Cor e Forma:SolidPeso molecular:228.24SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Fórmula:C15H21N5O3S2Pureza:98.26%Cor e Forma:SolidPeso molecular:383.49Ref: TM-T12919
1mg92,00€5mg215,00€1mL*10mM (DMSO)236,00€10mg344,00€25mg587,00€50mg803,00€100mg1.099,00€200mg1.468,00€SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Fórmula:C24H29ClN8O4SPureza:98.68%Cor e Forma:SolidPeso molecular:561.06SIRT1-IN-1
CAS:SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.Fórmula:C14H16N2OPureza:99.58%Cor e Forma:SolidPeso molecular:228.29Ref: TM-T9648
1mg92,00€5mg192,00€1mL*10mM (DMSO)195,00€10mg295,00€25mg505,00€50mg708,00€100mg964,00€200mg1.288,00€SIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Fórmula:C55H91N9O15SCor e Forma:SolidPeso molecular:1150.43Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Fórmula:C21H20N4O3S2Pureza:98%Cor e Forma:SolidPeso molecular:440.54SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Fórmula:C22H24N2O9SCor e Forma:SolidPeso molecular:492.5MIND4-19
CAS:MIND4-19 is an inhibitor of SIRT2 with antitumor activity.Fórmula:C22H19N3OSPureza:99.9%Cor e Forma:SolidPeso molecular:373.47Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Fórmula:C17H15FN2OPureza:99.54%Cor e Forma:White SolidPeso molecular:282.31SIRT1 activator 1
SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp.Pureza:98%Cor e Forma:Odour SolidSIRT-IN-5
SIRT-IN-5, a selective inhibitor of SIRT3 with an IC50 of 2.88 μM, facilitates the differentiation of multiple myeloma cells. This differentiation is associated with increased expression of the differentiation antigens CD49e and human immunoglobulin light chains λ and κ.Cor e Forma:Odour SolidSIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Fórmula:C22H25ClN8O2SPureza:99.56%Cor e Forma:SolidPeso molecular:501Et-29
CAS:Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.Fórmula:C34H46N6O6SPureza:99.52%Cor e Forma:White SolidPeso molecular:666.83SIRT2-IN-17
SIRT2-IN-17 (compound Z18) is a potent inhibitor of SIRT2, effectively reducing the expression of α-SMA and p-Smad2/3.Fórmula:C24H15N3O2SCor e Forma:SolidPeso molecular:409.46WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Fórmula:C25H21N5O2SPureza:99.33%Cor e Forma:SolidPeso molecular:455.53Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Fórmula:C19H15N3O2SPureza:99.67%Cor e Forma:Yellow SolidPeso molecular:349.41Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Fórmula:C20H15N3O2SPureza:99.32%Cor e Forma:SolidPeso molecular:361.42SIRT3 activator 1
SIRT3 Activator 1 (Compound 5v) is a selective activator of SIRT3. It enhances the expression of SIRT3, leading to upregulation of SOD2 and OPA1. This activity effectively mitigates mitochondrial dysfunction, alleviates oxidative stress, and maintains the vitality of cardiac myocytes. SIRT3 Activator 1 is useful in the study of cardiovascular diseases.Fórmula:C32H41N2NaO5Cor e Forma:SolidPeso molecular:556.67SIRT2-IN-12
SIRT2-IN-12 (Compound 3) is a SIRT2 inhibitor with an IC50 value of 50 μM.Fórmula:C23H21Cl2NO3Cor e Forma:SolidPeso molecular:429.08985ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Fórmula:C26H29I2NO3Pureza:99.23%Cor e Forma:SolidPeso molecular:657.32SIRT5 inhibitor 3
CAS:SIRT5 inhibitor 3 is potent and competitive by inhibiting SIRT5 deacetylation, with potential in metabolic, cancer, neurodegenerative, cardiovascular .Fórmula:C22H12FN3O4Pureza:98%Cor e Forma:SolidPeso molecular:401.35Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.Fórmula:C13H13ClN2OPureza:99.86%Cor e Forma:SolidPeso molecular:248.71Ref: TM-T7058
1mg142,00€2mg203,00€5mg314,00€1mL*10mM (DMSO)359,00€10mg447,00€25mg713,00€50mg1.018,00€Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Fórmula:C51H34N6Na6O23S6Pureza:97.47% - 99.97%Cor e Forma:WhitePeso molecular:1429.15SRT1720 hydrochloride
CAS:SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).Fórmula:C25H24ClN7OSPureza:98% - 99.93%Cor e Forma:Yellow SolidPeso molecular:506.22Ref: TM-T2412
1mg65,00€2mg85,00€5mg132,00€1mL*10mM (DMSO)210,00€10mg236,00€25mg374,00€50mg532,00€100mg758,00€200mg1.044,00€500mg1.549,00€Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Fórmula:C11H15ClN2O5Pureza:98.92% - 99.86%Cor e Forma:SolidPeso molecular:290.7AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Fórmula:C19H21N3O5SPureza:98.32% - 99.44%Cor e Forma:SolidPeso molecular:403.45E1231
CAS:E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.Fórmula:C21H21N3O3Pureza:98.45%Cor e Forma:SolidPeso molecular:363.41YK-3-237
CAS:YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferativeFórmula:C19H21BO7Pureza:99.47%Cor e Forma:SolidPeso molecular:372.18Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Fórmula:C16H18O9Pureza:98.97% - ≥95%Cor e Forma:White SolidPeso molecular:354.31Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Fórmula:C37H46O12Pureza:99.06% - ≥95%Cor e Forma:SolidPeso molecular:682.753-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Fórmula:C7H6N4Pureza:99.16% - >99.99%Cor e Forma:SolidPeso molecular:146.15Ref: TM-T4108
2mg37,00€5mg50,00€1mL*10mM (DMSO)50,00€10mg88,00€25mg158,00€50mg235,00€100mg371,00€200mg530,00€Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Fórmula:C20H23N3O2SPureza:99.33%Cor e Forma:SolidPeso molecular:369.48Dihydrocoumarin
CAS:Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).Fórmula:C9H8O2Pureza:98.46%Cor e Forma:SolidPeso molecular:148.16Gardenia yellow
CAS:Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.Fórmula:C44H64O24Pureza:98.24% - 98.82%Cor e Forma:Orange Yellow To Reddish Yellow PowderPeso molecular:976.96Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Fórmula:C25H34N4O2SPureza:98.89% - >99.99%Cor e Forma:SolidPeso molecular:454.63Ref: TM-T1818
1mg40,00€2mg52,00€5mg73,00€1mL*10mM (DMSO)74,00€10mg93,00€25mg148,00€50mg219,00€100mg371,00€500mg882,00€Selisistat
CAS:Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM).Fórmula:C13H13ClN2OPureza:98.53% - 99.94%Cor e Forma:SolidPeso molecular:248.71Ref: TM-T6111
5mg48,00€1mL*10mM (DMSO)50,00€10mg54,00€25mg87,00€50mg133,00€100mg222,00€200mg330,00€500mg535,00€SRT 1720 dihydrochloride
CAS:SRT 1720 dihydrochloride is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Fórmula:C25H25Cl2N7OSPureza:98.58%Cor e Forma:SolidPeso molecular:542.48Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Fórmula:C20H24O11Pureza:99.71% - 99.98%Cor e Forma:White PowderPeso molecular:440.40SirReal2
CAS:SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.Fórmula:C22H20N4OS2Pureza:99.52% - 99.75%Cor e Forma:SolidPeso molecular:420.55Ref: TM-T6984
1mg37,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)86,00€10mg102,00€25mg187,00€50mg295,00€100mg477,00€Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Fórmula:C30H42O7Pureza:98.06% - 99.98%Cor e Forma:White SolidPeso molecular:514.65AGK2
CAS:AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor.Fórmula:C23H13Cl2N3O2Pureza:98.68% - 99.17%Cor e Forma:SolidPeso molecular:434.27Ref: TM-T6371
1mg34,00€2mg46,00€5mg70,00€1mL*10mM (DMSO)77,00€10mg90,00€25mg177,00€50mg281,00€100mg444,00€500mg982,00€Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Fórmula:C26H22N2O2Pureza:97.09% - 99.55%Cor e Forma:SolidPeso molecular:394.47Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Fórmula:C25H19N5OS2Pureza:98% - 99.36%Cor e Forma:SolidPeso molecular:469.58UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Fórmula:C16H13N3Pureza:98.31%Cor e Forma:SolidPeso molecular:247.29Ref: TM-T7679
1mg38,00€5mg77,00€1mL*10mM (DMSO)95,00€10mg110,00€25mg215,00€50mg306,00€100mg429,00€200mg600,00€SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Fórmula:C25H23N7OSPureza:98.84%Cor e Forma:SolidPeso molecular:469.56Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Fórmula:C34H51N3O3SPureza:99.16%Cor e Forma:SolidPeso molecular:581.85Ref: TM-T3447
1mg54,00€2mg73,00€5mg92,00€10mg117,00€1mL*10mM (DMSO)117,00€25mg215,00€50mg360,00€100mg537,00€Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Fórmula:C13H13ClN2OPureza:99.8%Cor e Forma:White SolidPeso molecular:248.71Ref: TM-T15263
1mg101,00€2mg150,00€5mg245,00€1mL*10mM (DMSO)269,00€10mg356,00€25mg597,00€50mg835,00€100mg1.108,00€Ophiopogonin D'
CAS:Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.Fórmula:C44H70O16Pureza:99.69% - 99.77%Cor e Forma:White SolidPeso molecular:855.02Ref: TM-TN1071
1mg114,00€5mg289,00€10mg432,00€1mL*10mM (DMSO)533,00€25mg692,00€50mg945,00€100mg1.251,00€
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