Sirtuína
As sirtuínas são uma família de desacetilases dependentes de NAD+ que desempenham um papel crucial na regulação de processos celulares como reparo de DNA, envelhecimento, metabolismo e resistência ao estresse. As sirtuínas influenciam o reparo do DNA ao desacetilar proteínas envolvidas nas vias de reparo, modulando assim sua atividade. Inibidores e ativadores de sirtuínas são ferramentas valiosas em pesquisas sobre envelhecimento, câncer e doenças metabólicas, onde a regulação do reparo do DNA e da longevidade celular é de interesse. Na CymitQuimica, oferecemos uma gama de moduladores de sirtuínas de alta qualidade para apoiar sua pesquisa em reparo de DNA, envelhecimento celular e regulação metabólica.
Foram encontrados 91 produtos para "Sirtuína".
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SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Fórmula:C26H24N6O2S2Pureza:98.34% - 99.82%Cor e Forma:Yellow SolidPeso molecular:516.64Ref: TM-T6679
1mg43,00€5mg93,00€10mg124,00€25mg219,00€50mg358,00€100mg533,00€200mg763,00€500mg1.161,00€1g1.558,00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Fórmula:C19H14N2O6Pureza:97.47% - 98.6%Cor e Forma:SolidPeso molecular:366.32AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Fórmula:C23H13Cl2N3O2Pureza:98.31%Cor e Forma:SolidPeso molecular:434.27SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Fórmula:C27H24N4O2SPureza:97.86%Cor e Forma:SolidPeso molecular:468.57Ref: TM-T16932
1mg52,00€2mg69,00€5mg102,00€1mL*10mM (DMSO)105,00€10mg157,00€25mg268,00€50mg408,00€100mg590,00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Fórmula:C19H21BrN2O3SPureza:98.43% - 99.34%Cor e Forma:White SolidPeso molecular:437.35Ref: TM-T5490
1mg34,00€2mg47,00€5mg71,00€1mL*10mM (DMSO)89,00€10mg100,00€25mg177,00€50mg313,00€100mg512,00€Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Fórmula:C15H10O6Pureza:94.14% - 99.05%Cor e Forma:Yellow SolidPeso molecular:286.244'-bromo-Resveratrol
CAS:4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)Fórmula:C14H11BrO2Pureza:99.00%Cor e Forma:SolidPeso molecular:291.14CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Fórmula:C22H15FN4O2SPureza:98.92%Cor e Forma:SolidPeso molecular:418.44SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Fórmula:C15H12ClN3OPureza:99.79%Cor e Forma:SolidPeso molecular:285.73Ref: TM-T39233
1mg90,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg334,00€25mg567,00€50mg807,00€100mg1.099,00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Fórmula:C25H35ClN4O2SPureza:99.36%Cor e Forma:SolidPeso molecular:491.09Ref: TM-T8480
1mg37,00€2mg49,00€5mg66,00€1mL*10mM (DMSO)70,00€10mg84,00€25mg133,00€50mg215,00€100mg356,00€SRT 1460
CAS:SRT 1460 is a SIRT1 activator.Fórmula:C26H29N5O4SPureza:98.25%Cor e Forma:SolidPeso molecular:507.6Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Fórmula:C21H16N2O2SPureza:98.02% - 99.83%Cor e Forma:SolidPeso molecular:360.43Ref: TM-T4019
1mg38,00€2mg50,00€1mL*10mM (DMSO)63,00€5mg80,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Fórmula:C26H22N2O2Pureza:97.12% - 99.96%Cor e Forma:Yellow SolidPeso molecular:394.47Ref: TM-T6671
2mg40,00€5mg55,00€1mL*10mM (DMSO)55,00€10mg88,00€25mg170,00€50mg324,00€100mg482,00€500mg1.063,00€B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFórmula:C20H17ClN4O3Pureza:99.66%Cor e Forma:SolidPeso molecular:396.83MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Fórmula:C21H16BrCl2FN2O6S2Pureza:99.95% - 99.96%Cor e Forma:SolidPeso molecular:626.3SIRT6 activator 12q
CAS:SIRT6 activator 12q is a SIRT6 activator; EC50=5.3 μM; allosteric modulator; metabolism and aging research.Fórmula:C31H22N2O2Pureza:98.53%Cor e Forma:White SolidPeso molecular:454.52SIRT5 inhibitor 5
CAS:SIRT5 inhibitor 5 is a selective and substrate-competitive SIRT5 inhibitor, which does not occupy the NAD+ binding pocket,cancer and metabolism-related disease.Fórmula:C21H14ClN3O3SPureza:99.33%Cor e Forma:SolidPeso molecular:423.87SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Fórmula:C21H22N6OS2Pureza:97.6%Cor e Forma:Yellow SolidPeso molecular:438.57SIRT5 inhibitor 6
CAS:SIRT5 inhibitor 6 is Sirtuin 5 inhibitor for sepsis-associated acute kidney injury (AKI) modulates protein succinylation and pro-inflammatory cytokine release.Fórmula:C21H28N6O4SPureza:99.84%Cor e Forma:SolidPeso molecular:460.55SIRT5 inhibitor 4
CAS:SIRT5 inhibitor 4 (compound 11) is a dose-dependent and selective SIRT5 (Sirtuin5) inhibitorand no inhibitory effect on SIRT1/2/3,anticancer.Fórmula:C18H15N3O4SPureza:99.97%Cor e Forma:SolidPeso molecular:369.39SIRT5 inhibitor 2
CAS:SIRT5 inhibitor 2 (compound 49) has inhibitory activity through SIRT5-dependent deacetylation and cancer and neurodegenerative diseases.Fórmula:C18H12Cl2N2O3SPureza:99.38% - 99.87%Cor e Forma:SolidPeso molecular:407.27Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Fórmula:C28H27N7O2S2Pureza:99.57% - 99.84%Cor e Forma:SolidPeso molecular:557.69Ref: TM-T12920
1mg100,00€5mg203,00€1mL*10mM (DMSO)253,00€10mg323,00€25mg513,00€50mg697,00€100mg888,00€500mg1.783,00€SIRT2-IN-11
CAS:SIRT2-IN-11 is a selective SIRT2 inhibitor; IC50=12 nM; increases tubulin acetylation; cancer research tool.Fórmula:C21H22N2OCor e Forma:SolidPeso molecular:318.412-APQC
CAS:2-APQC is a selective, orally active Sirtuin-3 (SIRT3) agonist (Kd=2.756 μM) that modulates mitochondrial homeostasis. It attenuates ISO-induced myocardial hypertrophy and fibrosis in vivo and in vitro, making it suitable for heart failure research. 2-APQC inhibits mTOR-p70S6K, JNK, TGF-β/Smad3, and ROS-p38MAPK pathways while activating PYCR1 and AMPK-Parkin, thereby suppressing necrosis and mitigating mitochondrial oxidative damage.Fórmula:C23H24FN5OPureza:99.88%Cor e Forma:White SolidPeso molecular:405.47Ref: TM-T88667
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg212,00€25mg358,00€50mg512,00€100mg707,00€SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Fórmula:C19H14N2O6Pureza:98.77%Cor e Forma:SolidPeso molecular:366.32SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Fórmula:C31H39FN6O6S2Pureza:97.8%Cor e Forma:White SolidPeso molecular:674.81Ref: TM-T12921
1mg138,00€2mg197,00€5mg334,00€1mL*10mM (DMSO)442,00€10mg502,00€25mg884,00€50mg1.288,00€100mg1.728,00€Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Fórmula:C31H32ClN5O2S2Pureza:99.63%Cor e Forma:Yellow SolidPeso molecular:606.2Epigenetic factor-IN-1
CAS:Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.Fórmula:C32H34FN5O6S2Pureza:98%Cor e Forma:SolidPeso molecular:667.77SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFórmula:C21H30Br3ClN6SPureza:98%Cor e Forma:SolidPeso molecular:673.73Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Fórmula:C20H17N3O2Pureza:99.1% - 99.87%Cor e Forma:White SolidPeso molecular:331.37SIRT-IN-1
CAS:SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).Fórmula:C19H27N5O2SPureza:99.29%Cor e Forma:SolidPeso molecular:389.52Ref: TM-T12918
1mg57,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg192,00€25mg409,00€50mg670,00€100mg954,00€SIRT5 inhibitor 7
CAS:SIRT5 inhibitor 7 , a substrate-competitive and selective SIRT5 inhibitor, significantly attenuated renal dysfunction and pathological damage in AKI mice.Fórmula:C28H32ClN7O3SPureza:99.77%Cor e Forma:SolidPeso molecular:582.12SRT3657
CAS:SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.Fórmula:C40H54N8O6SPureza:98%Cor e Forma:SolidPeso molecular:774.97SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Fórmula:C23H23N3O6Cor e Forma:SolidPeso molecular:437.45SIRT2-IN-14
CAS:**SIRT2-IN-14 (Compound 78)** is a selective SIRT2 inhibitor, demonstrating an IC50 value of 0.196 μM [1].Fórmula:C26H21N3O4Cor e Forma:SolidPeso molecular:439.46SIRT1-IN-5
CAS:SIRT1-IN-5 (215) is a modulator of NAD-dependent deacetylase SIRT1 with potential applications in cancer and cellular signaling research.Fórmula:C21H17N3O3SPureza:99.97%Cor e Forma:SolidPeso molecular:391.44CL5D
CAS:CL5D is an activator of the protein deacetylase SIRT6. It significantly enhances the deacetylase activity and catalytic efficiency of SIRT6. CL5D modulates SIRT6 activity by promoting its conformational changes, particularly relying on the Arg-65 residue. This compound can be used to study the activation mechanism of SIRT6 and its roles in metabolism, DNA repair, and aging.Fórmula:C29H11Cl7N2O6Peso molecular:731.58DCHC
CAS:DCHC is an activator of SIRT1, but it does not induce SIRT1 expression. This compound can be utilized in studies related to mitochondrial damage.Fórmula:C15H8Cl2O3Cor e Forma:SolidPeso molecular:307.128Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Fórmula:C28H46N8O6SCor e Forma:SolidPeso molecular:622.78MC3138
CAS:MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Fórmula:C25H25NO6Pureza:99.57%Cor e Forma:Yellow SolidPeso molecular:435.47SIRT-IN-6
CAS:SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.Fórmula:C7H4ClN3OSCor e Forma:SolidPeso molecular:213.644
