Alquilação de DNA
A alquilação do DNA envolve a adição de grupos alquila à molécula de DNA, levando à formação de lesões que podem interferir na replicação e transcrição do DNA. Agentes alquilantes de DNA são comumente usados na quimioterapia do câncer para induzir danos ao DNA em células de rápida divisão. No entanto, as células têm mecanismos para reparar essas lesões, e inibidores das vias de reparo da alquilação do DNA podem aumentar a eficácia dos agentes alquilantes. Na CymitQuimica, oferecemos uma seleção de reagentes e inibidores de alquilação do DNA de alta qualidade para apoiar sua pesquisa em danos ao DNA, mecanismos de reparo e terapia do câncer.
Foram encontrados 22 produtos para "Alquilação de DNA".
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Methyl methanesulfonate
CAS:Methyl methanesulfonate alkylates adenine and guanine, causing base mismatches and replication issues.Fórmula:C2H6O3SPureza:99.69%Cor e Forma:SolidPeso molecular:110.13Chlorambucil
CAS:Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard.Fórmula:C14H19Cl2NO2Pureza:97.37% - 98.45%Cor e Forma:Off-White Slightly Granular Powder Melting Point 65-69°CPeso molecular:304.21Altretamine
CAS:Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.Fórmula:C9H18N6Pureza:99.54%Cor e Forma:White SolidPeso molecular:210.28N-Ethyl-N-nitrosourea
CAS:N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent that damages DNA, inducing bone marrow suppression, leukemia, tumorigenesis, and genetic disorders.Fórmula:C3H7N3O2Pureza:99.97%Cor e Forma:White SolidPeso molecular:117.11Phosphoramide mustard
CAS:Phosphoramide mustard is a toxic metabolite of cyclophosphamide with anticancer activity and ovarian toxicity that induces DNA damage.Fórmula:C4H11Cl2N2O2PPureza:93% - 93.00%Cor e Forma:SolidPeso molecular:221.02Melphalan
CAS:Melphalan is an orally bioavailable DNA alkylating agent exhibiting antitumour activity, commonly employed in cancer chemotherapy.Fórmula:C13H18Cl2N2O2Pureza:98.03%Cor e Forma:White SolidPeso molecular:305.2Methyl methanesulfonate (Standard)
CAS:Methyl methanesulfonate (Standard) is a standard material used in the analysis of methyl methanesulfonate, typically referenced in its research and analysis.Fórmula:C2H6O3SCor e Forma:SolidPeso molecular:110.13Phosphoramide mustard cyclohexanamine
CAS:Phosphoramide mustard cyclohexanamine is active metabolite of cyclophosphamide, an alkylating agent that cross-links DNA strands,causes cell death, antitumor.Fórmula:C10H24Cl2N3O2PPureza:95%Cor e Forma:SolidPeso molecular:320.20GNE-3511
CAS:GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.Fórmula:C23H26F2N6OPureza:98.3% - 99.51%Cor e Forma:SolidPeso molecular:440.4889VAL-083
CAS:VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity.Fórmula:C6H10O4Pureza:97.94%Cor e Forma:SolidPeso molecular:146.1412Treosulfan
CAS:Treosulfan (NSC 39069) is a bifunctional alkylating agent used in the treatment of advanced ovarian cancer.Cost-effective and quality-assured.Fórmula:C6H14O8S2Pureza:99.26% - 99.83%Cor e Forma:SolidPeso molecular:278.301Carmustine
CAS:Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.Fórmula:C5H9Cl2N3O2Pureza:98% - 99.97%Cor e Forma:Yellow LiquidPeso molecular:214.05Palifosfamide
CAS:Palifosfamide lysine (ZIO-201) stable, effective vs. sarcomas in vitro. IC50: 2.25-6.75 μM, except OS222 at 31.5 μM.Fórmula:C4H11Cl2N2O2PPureza:99.72%Cor e Forma:Transparent ViscousPeso molecular:221.02Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Fórmula:C10H8BrN5OSPureza:99.26% - >99.99%Cor e Forma:SolidPeso molecular:326.17Tretazicar
CAS:CB1954, an anticancer prodrug, turns into a potent alkylating agent when activated by NQO2 and EP-0152R.Fórmula:C9H8N4O5Pureza:99.41% - 99.7%Cor e Forma:White SolidPeso molecular:252.1836Satraplatin
CAS:Satraplatin (BMS182751) is an orally available antineoplastic platinum(IV) complex.Satraplatin has a favorable toxicity profile and appears to have clinicalFórmula:C10H22Cl2N2O4PtPureza:98.25%Cor e Forma:SolidPeso molecular:500.28LIV-1205
LIV-1205 is an antibody inhibitor that targets DLK1 and can be used to study DLK1-related signaling pathways and mechanisms.Pureza:97.5% (SDS-PAGE); 100% (SEC-HPLC) - 97.5% (SDS-PAGE); 100% (SEC-HPLC)Miriplatin hydrate
CAS:Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).Fórmula:C34H70N2O5PtPureza:99.6%Cor e Forma:White SolidPeso molecular:782.01DN-1289
DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.Fórmula:C18H19F4N7O2Pureza:99.03%Cor e Forma:SolidPeso molecular:441.38GNE-8505
CAS:GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).Fórmula:C21H24F3N5OCor e Forma:SolidPeso molecular:419.44
