Receptor de hormónio tireoidiano (THR)
Os receptores de hormônio tireoidiano (THR) são receptores nucleares que mediam os efeitos dos hormônios tireoidianos, que são críticos para a regulação do metabolismo, crescimento e desenvolvimento. A modulação da atividade dos THR é importante no tratamento de distúrbios da tireoide, síndromes metabólicas e certos tipos de câncer. Agonistas e antagonistas de THR são usados em pesquisas para estudar os papéis fisiológicos e patológicos dos hormônios tireoidianos. Na CymitQuimica, oferecemos uma ampla gama de moduladores de receptores de hormônio tireoidiano de alta qualidade para apoiar sua pesquisa em endocrinologia, metabolismo e regulação hormonal.
Foram encontrados 39 produtos para "Receptor de hormónio tireoidiano (THR)".
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(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
D-Trp12,Tyr34-pTH(7-34) (bovine) is a PTH antagonist with a Ki of 69 nM in bovine kidneys.Fórmula:C167H255N49O42S2Pureza:99.17%Cor e Forma:SolidPeso molecular:3685.25REVERSE T3
CAS:Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.Fórmula:C15H12I3NO4Pureza:95.99% - 97.89%Cor e Forma:SolidPeso molecular:650.97Eprotirome
CAS:Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.Fórmula:C18H17Br2NO5Pureza:98.42% - 98.56%Cor e Forma:SolidPeso molecular:487.14Ref: TM-T5360
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg80,00€25mg145,00€50mg222,00€100mg356,00€200mg522,00€Resmetirom
CAS:Resmetirom (MGL-3196) is a THR-β agonist (EC50=0.21 μM), with high selectivity and oral activity. High-Quality, Low-Cost!Fórmula:C17H12Cl2N6O4Pureza:99.05% - >99.99%Cor e Forma:White SolidPeso molecular:435.22Ref: TM-T3595
1mg37,00€2mg49,00€1mL*10mM (DMSO)87,00€5mg93,00€10mg119,00€25mg202,00€50mg324,00€100mg482,00€500mg1.071,00€DPC AJ1951 acetate
DPC-AJ1951 acetate: 14-amino acid peptide, potent PTH/PPR agonist, tested for bone resorption activity ex vivo/in vivo.Fórmula:C78H131N23O21Pureza:99.87%Cor e Forma:White SolidPeso molecular:1727.02Sobetirome
CAS:Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).Fórmula:C20H24O4Pureza:98.08% - 98.25%Cor e Forma:White SolidPeso molecular:328.43,3',5-Triiodothyronine-(tyrosine ring-13C6)
CAS:3,3',5-Triiodothyronine-(tyrosine ring-13C6) is the 13C labeled compound of 3,3',5-Triiodothyronine. 3,3',5-Triiodothyronine has a CAS number of 5817-39-0.Fórmula:C4C11H12I3NO4Cor e Forma:SolidPeso molecular:656.93Glutaurine
CAS:Glutaurine is a newly detected hormone of the parathyroid gland. Glutaurine has been observed to exhibit antiepileptic effects with anti-amnesia properties, which mimics the anxiolytic drug Diazepam.Fórmula:C7H14N2O6SPeso molecular:254.26Azetirelin
CAS:Azetirelin, as a TRH analog, has a more potent effect than TRH on the central nervous system.Fórmula:C15H20N6O4Pureza:99.72%Cor e Forma:SolidPeso molecular:348.36Glutaurine aceate
Glutaurine aceate containing glutamine and taurine residues is an orally active hormone of the parathyroid.Fórmula:C9H18N2O8SPureza:98%Cor e Forma:SolidPeso molecular:314.31KAT681
CAS:KAT681 is a liver selective thyromimetic.Fórmula:C24H22FNNaO6Pureza:98%Cor e Forma:SolidPeso molecular:462.429MB-07344
CAS:MB-07344 is a selective THR-β (thyroid hormone receptor β) agonist with a Ki of 2.17 nM, capable of reducing plasma total cholesterol (TPC).Fórmula:C19H25O5PPureza:99.32%Cor e Forma:White SolidPeso molecular:364.37TR antagonist 1
CAS:TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist that can be used to study diseases caused by endocrine abnormalities.Fórmula:C25H23Br2NO4Pureza:99.57%Cor e Forma:SolidPeso molecular:561.26CO23
CAS:CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.Fórmula:C19H18I2N2O4Pureza:98.08%Cor e Forma:SolidPeso molecular:592.17DS08210767
CAS:DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.Fórmula:C31H39N5O2Pureza:98.79%Cor e Forma:SolidPeso molecular:513.67MB-07811
CAS:MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity.Fórmula:C28H32ClO5PPureza:99.74% - 99.94%Cor e Forma:SolidPeso molecular:514.98Octadecyl β-D-glucopyranosiduronic acid
CAS:Octadecyl β-D-glucopyranosiduronic acid (Compound 9) is an activator of parathyroid hormone 1 receptor (PTH1R) with a pEC50 value greater than 9. It can be utilized in research related to hypoparathyroidism.Fórmula:C24H46O7Peso molecular:446.63THR-β agonist 11
CAS:THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. It demonstrates robust cholesterol-lowering effects in cholesterol-fed rats. In a high-fat diet-carbon tetrachloride (HFD-CCl4) induced model of metabolic dysfunction-associated steatohepatitis (MASH) in mice, THR-β agonist 11 significantly reduces serum total triglycerides (TG), low-density lipoprotein cholesterol (LDL-cholesterol), liver total cholesterol (TC), and TG levels. Additionally, it alleviates hepatic steatosis, inflammation, and fibrosis. THR-β agonist 11 is applicable in the study of MASH and other fibrotic diseases.Fórmula:C26H30ClN2O5PPeso molecular:516.96MLS000389544
CAS:MLS000389544 is a selective and potent thyroid hormone receptor β (TRβ) antagonist with a methylsulfonyl nitrobenzoic acid structure. It effectively inhibits the interaction between TRβ and steroid receptor coactivator 2 (SRC2).Fórmula:C20H24N2O7SCor e Forma:SolidPeso molecular:436.479
