Receptor de Androgénio
O receptor de andrógenos (AR) é um receptor hormonal nuclear que é ativado pela ligação a andrógenos, como a testosterona e a diidrotestosterona. Este receptor desempenha um papel crucial no desenvolvimento e na manutenção das características masculinas, bem como na regulação de vários processos fisiológicos, incluindo o crescimento muscular, a libido e a densidade óssea. Inibidores do receptor de andrógenos são amplamente estudados no contexto do câncer de próstata, onde a sinalização do AR é frequentemente aumentada. Na CymitQuimica, oferecemos uma gama de moduladores do receptor de andrógenos de alta qualidade para apoiar sua pesquisa em endocrinologia, biologia do câncer e regulação hormonal.
Foram encontrados 207 produtos de "Receptor de Androgénio"
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BWA-6047
<p>BWA-6047 is a dual AR/AR-V7 and GSPT1 PROTAC-type degrader (AR: DC50= 3.7 nM; AR-V7: DC50= 3.0 nM; GSPT1: DC50= 1.2 nM). It facilitates the ubiquitination and degradation of AR/AR-V7 and, through molecular glue properties, induces a PPI between GSPT1 and CRBN, leading to GSPT1 degradation. BWA-6047 is applicable in prostate cancer research.</p>Fórmula:C42H46ClN5O7Cor e Forma:SolidPeso molecular:767.308582-sec-Butylphenol
CAS:<p>2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.</p>Fórmula:C10H14OCor e Forma:SolidPeso molecular:150.22RLA-4842
<p>RLA-4842: iron-based anti-androgen; inhibits mCRPC cell proliferation.</p>Fórmula:C42H46F3N5O8SCor e Forma:SolidPeso molecular:837.9Ludaterone
CAS:<p>Ludaterone is an antiandrogen agent, with potent antiandrogenic activity.</p>Fórmula:C20H25ClO5Cor e Forma:SolidPeso molecular:380.86Gridegalutamide
CAS:<p>Gridegalutamide exhibits anti-androgen and anti-tumor activities.</p>Fórmula:C41H45F3N8O5SCor e Forma:SolidPeso molecular:818.91PROTAC AR-V7 degrader-1
CAS:<p>Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.</p>Fórmula:C41H52N6O6S2Cor e Forma:SolidPeso molecular:789.023-Cl-Pyridine-amide-acrylaldehyde-piperazine
<p>3-Cl-Pyridine-amide-acrylaldehyde-piperazine serves as a synthetic intermediate for LO-4-25. LO-4-25 is a ligand for the androgen receptor (AR) DNA binding domain and is linked to a truncated fumaramide handle via a connector. In 22Rv1 cells, LO-4-25 demonstrates potent degradation of both AR and AR-V7.</p>Cor e Forma:Odour SolidARD-69
<p>ARD-69, a potent PROTAC, degrades AR in prostate cancer, with low DC50 values in AR+ cell lines, and suppresses AR gene expression.</p>Fórmula:C62H74ClFN8O7SCor e Forma:SolidPeso molecular:1129.83TD-802
CAS:<p>TD-802, an AR-targeting PROTAC with microsomal stability, shows promise for castration-resistant prostate cancer.</p>Fórmula:C52H61ClN10O6Cor e Forma:SolidPeso molecular:957.56ARD-2051
CAS:<p>ARD-2051 is a potent, orally active proteolysis-targeting chimera degrader of the androgen receptor (AR), exhibiting DC50 values of 0.6 nM in degrading AR</p>Fórmula:C43H45ClN8O5Pureza:98%Cor e Forma:SolidPeso molecular:789.32RLA-5331
<p>RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.</p>Fórmula:C40H43F3N6O7SCor e Forma:SolidPeso molecular:808.87Inocoterone acetate
CAS:<p>Inocoterone acetate is a nonsteroidal antiandrogen that binds to the androgen receptor and possesses antiandrogenic activity in animal models.</p>Fórmula:C18H26O3Cor e Forma:SolidPeso molecular:290.40BWA-522
<p>BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL)</p>Fórmula:C43H51ClN4O7Pureza:98%Cor e Forma:SolidPeso molecular:771.34Adrenocorticotropic hormone
CAS:<p>ACTH, a polypeptide, is secreted by the pituitary gland and regulates cortisol and androgen.</p>Cor e Forma:SolidEnzalutamide-d3
CAS:<p>Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.</p>Fórmula:C21H16F4N4O2SCor e Forma:SolidPeso molecular:467.45Anti-Androgen receptor Antibody (8R912)
<p>Anti-Androgen receptor Antibody (8R912) is a Mouse antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (8R912) can be used in ICC/IF.</p>Cor e Forma:Odour LiquidAnti-Androgen receptor Antibody (7Q574)
<p>Anti-Androgen receptor Antibody (7Q574) is an antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (7Q574) can be used in ELISA, WB, IHC.</p>Cor e Forma:Odour Liquid(Rac)-PF-998425
CAS:<p>(Rac)-PF-998425: nonsteroidal AR antagonist, potent & selective, IC50: 26 nM (binding), 90 nM (cellular), potential for androgenetic alopecia study.</p>Fórmula:C14H14F3NOCor e Forma:SolidPeso molecular:269.267Anti-Androgen receptor Antibody (8H883)
<p>Anti-Androgen receptor Antibody (8H883) is an antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (8H883) can be used in ELISA, IHC.</p>Cor e Forma:Odour LiquidD4-abiraterone
CAS:<p>D4-abiraterone is the active metabolite of abiraterone.Δ4-Abiraterone is a inhibitor of CYP17A1, 3β-HSD and SRD5A, and an antagonist of the androgen receptor.</p>Fórmula:C24H29NOPureza:99.75% - 99.8%Cor e Forma:SolidPeso molecular:347.49
