Receptor de Androgénio
O receptor de andrógenos (AR) é um receptor hormonal nuclear que é ativado pela ligação a andrógenos, como a testosterona e a diidrotestosterona. Este receptor desempenha um papel crucial no desenvolvimento e na manutenção das características masculinas, bem como na regulação de vários processos fisiológicos, incluindo o crescimento muscular, a libido e a densidade óssea. Inibidores do receptor de andrógenos são amplamente estudados no contexto do câncer de próstata, onde a sinalização do AR é frequentemente aumentada. Na CymitQuimica, oferecemos uma gama de moduladores do receptor de andrógenos de alta qualidade para apoiar sua pesquisa em endocrinologia, biologia do câncer e regulação hormonal.
Foram encontrados 235 produtos para "Receptor de Androgénio".
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ERβ agonist-1
CAS:ERβagonist-1 (Compound 8) functions as a dual-active selective ERβ agonist (EC50: 46.8 nM) and an AR antagonist (IC50: 1555 nM). By binding to ERβ, it activates its signaling pathways while simultaneously inhibiting AR activity. Retaining selective ERβ agonist activity in mouse models, ERβagonist-1 is applicable in prostate cancer research.Fórmula:C25H36O2Cor e Forma:SolidPeso molecular:368.55TLB 150 Benzoate
CAS:TLB 150 Benzoate (RAD150) is a modulator of the androgen receptor with an IC50 value of 0.13 μM.Fórmula:C27H20ClN5O3Cor e Forma:SolidPeso molecular:497.932-Ethylhexyl(E)-3-(4-(methoxy-D3) phenyl)acrylate
CAS:2-Ethylhexyl(E)-3-(4-(methoxy-D3) phenyl)acrylate is the deuterated form of Octinoxate. Octinoxate (Octyl methoxycinnamate) acts as an agonist of thyroid hormone receptors, leading to a reduction in triiodothyronine (T3) and thyroxine (T4) levels, as well as the transcription levels of type II deiodinase (deio2) related genes in Japanese Medaka. Commonly used as a safe ultraviolet (UV) filter in aquatic environments, Octinoxate inhibits CYP1A1 and CYP1B1, and influences hyaluronic acid (HA) metabolism in human keratinocytes through a PI3K pathway-dependent manner. It also exhibits both anti-estrogenic and anti-androgenic effects in vitro and in vivo.Fórmula:C18H26O3Peso molecular:293.42KF-19418
CAS:KF-19418 is a follicle stimulant that directly activates follicles in vitro and promotes hair growth in vivo.Fórmula:C21H14N4OCor e Forma:SolidPeso molecular:338.36PROTAC Androgen receptor degrader-1
CAS:PROTAC Androgen receptor degrader-1 is a PROTAC degrader targeting the androgen receptor (DC50 = 6 nM), prostate cancer.Fórmula:C43H48ClN9O2Pureza:99.49%Cor e Forma:Pink SolidPeso molecular:758.35ID11916
CAS:ID11916 is an orally active compound functioning as both an androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. It disrupts androgen binding to AR, impedes nuclear translocation, and blocks androgen-dependent transcriptional activity of AR, while simultaneously elevating intracellular cGMP levels by inhibiting PKG activation. Moreover, ID11916 exhibits potent anticancer effects in prostate cancer cell lines VCaP and 22Rv1, as well as in AR-positive breast cancer cell line SK-BR-3.Fórmula:C29H27F3N8O3SCor e Forma:SolidPeso molecular:624.637AR antagonist 4
AR antagonist 4 (Compound 67-b) is an orally active androgen receptor (AR) antagonist that acts on wild-type AR (IC50: 246.6 nM).Fórmula:C29H36N4OCor e Forma:SolidPeso molecular:456.62AR ligand-44
CAS:AR ligand-44 is an androgen receptor (androgen receptor) ligand that can be utilized in the synthesis of PROTACs such as [ARD-2051].Fórmula:C23H24ClN3O2Cor e Forma:SolidPeso molecular:409.91A4B17
A4B17 is an inhibitor of androgen receptor N-terminal with potential for androgen-responsive prostate cancer treatment.Fórmula:C14H7F4NSCor e Forma:SolidPeso molecular:297.27JNJ-1250132
CAS:JNJ-1250132 is a steroidal progesterone receptor modulator that inhibits binding of the receptor to DNA in vitro.Fórmula:C33H41NO4Cor e Forma:SolidPeso molecular:515.68Androgen receptor degrader-5
CAS:Androgen receptor degrader-5 (compound 14k) demonstrates superior capabilities, specifically in androgen receptor degradation and antiproliferative activity, showcasing its promising properties.Fórmula:C29H25F4N5O2Cor e Forma:SolidPeso molecular:551.53ZNU-IMB-Z15
CAS:Compound Z15 (ZNU-IMB-Z15) acts as an antagonist and degrader of the androgen receptor (AR). It inhibits the proliferation of castration-resistant prostate cancer (CRPC) cell lines that are AR-positive and induces apoptosis. Compound Z15 exhibits anticancer activity both in vivo and in vitro.Fórmula:C20H17N3O3S2Cor e Forma:SolidPeso molecular:411.5(Rac)-Idroxioleic acid sodium
CAS:(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) sodium is a synthetic derivative of oleic acid (OA) that binds to the plasma membrane, altering lipid composition. This compound exhibits antitumor properties.Fórmula:C18H33NaO3Cor e Forma:SolidPeso molecular:320.44Anti-Androgen receptor Antibody (8H883)
Anti-Androgen receptor Antibody (8H883) is an antibody targeting Androgen receptor. Anti-Androgen receptor Antibody (8H883) can be used in ELISA, IHC.Cor e Forma:Odour LiquidLGD-3303
CAS:LGD-3303 is an orally available and selective androgen receptor modulator.Fórmula:C16H14ClF3N2OPeso molecular:342.74
