Hidroxilase
As hidroxilases são uma classe de enzimas que catalisam a hidroxilação de substratos, frequentemente adicionando grupos hidroxila (-OH) a posições específicas dentro das moléculas. Estas enzimas estão envolvidas em uma ampla variedade de vias bioquímicas, incluindo a síntese de hormônios, processos de desintoxicação e o metabolismo de drogas. Inibidores e ativadores de hidroxilases são ferramentas valiosas na pesquisa sobre distúrbios metabólicos, metabolismo de drogas e regulação hormonal. Na CymitQuimica, oferecemos uma seleção de reagentes de hidroxilases de alta qualidade para apoiar sua pesquisa em bioquímica, farmacologia e regulação metabólica.
Foram encontrados 37 produtos para "Hidroxilase".
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Fenclonine
CAS:Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.Fórmula:C9H10ClNO2Pureza:98.81% - >99.99%Cor e Forma:Crystals From Methanol White SolidPeso molecular:199.634p-Ethynylphenylalanine hydrochloride
CAS:p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1].Fórmula:C11H12ClNO2Pureza:98.02% - 99.83%Cor e Forma:SolidPeso molecular:225.671ACT-678689
CAS:ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].Fórmula:C23H22ClFN6O4S2Pureza:99.46%Cor e Forma:SolidPeso molecular:565.04Telotristat ethyl
CAS:Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.Fórmula:C27H26ClF3N6O3Pureza:98% - 99.89%Cor e Forma:White SolidPeso molecular:574.982TPH1-IN-1
TPH1-IN-1 (compound 40) is a xanthine derivative that serves as an inhibitor of tryptophan hydroxylase TPH1, with an IC50 of 110.1 nM.Fórmula:C21H18N6O4SCor e Forma:SolidPeso molecular:450.47TPH2 agonist-1
TPH2 agonist-1 (compound 20e) is an orally active TPH2 agonist that can penetrate the blood-brain barrier and is derived from 1,3,4-oxadiazol-2(3H)-one. In models with SCN1A defects, TPH2 agonist-1 enhances TPH2 expression and increases levels of 5-HT and GABA, demonstrating anticonvulsant activity. It stabilizes neuronal network electrophysiological activity and suppresses abnormal spike and burst activities. TPH2 agonist-1 shows no significant hERG inhibition or cytotoxicity and is suitable for studies related to severe myoclonic epilepsy in infancy (Dravet syndrome).TPT-004
TPT-004, a TPH inhibitor, exhibits superior pharmacokinetic and pharmacodynamic properties, and demonstrates efficacy in preclinical models for attenuatingCor e Forma:Odour SolidGSK180
CAS:GSK180 is a potent KMO inhibitor (IC50 ~6 nM) that modulates kynurenine metabolism for metabolic, neurological, and inflammatory research.Fórmula:C10H7Cl2NO4Cor e Forma:White SolidPeso molecular:276.0732-Mercaptobenzothiazole (Standard)
CAS:2-Mercaptobenzothiazole (Standard) exhibits cell type-dependent cytotoxicity, induces cardiovascular developmental abnormalities in zebrafish, and can inhibit dopamine β-hydroxylase.Fórmula:C7H5NS2Peso molecular:167.25Cuprizone
CAS:Cuprizone is a copper chelator.Cuprizone is used to induce schizophrenia in mice.Cuprizone induces oligodendrocyte death and induces a demyelination response.Fórmula:C14H22N4O2Pureza:99.88% - 99.94%Cor e Forma:Yellow SolidPeso molecular:278.3501FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Fórmula:C12H9ClN2O4Pureza:97.13% - >99.99%Cor e Forma:SolidPeso molecular:280.664Nepicastat
CAS:Nepicastat (SYN117) is a potent, BBB-permeable, selective DBH inhibitor with IC50s of 8.5/9 nM in bovine/human.Fórmula:C14H15F2N3SCor e Forma:SolidPeso molecular:295.35Ro 61-8048
CAS:Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.Fórmula:C17H15N3O6S2Pureza:98% - >99.99%Cor e Forma:Yellow SolidPeso molecular:421.45p-Fluoro-L-phenylalanine
CAS:p-Fluoro-L-phenylalanine: TH substrate, studies enzyme regulation, binds E. coli L-leucine receptor, KD 0.26μM.Fórmula:C9H10FNO2Pureza:99.63%Cor e Forma:White SolidPeso molecular:183.1796Telotristat Etiprate
CAS:Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.Fórmula:C36H35ClF3N7O6Pureza:99.21% - 99.83%Cor e Forma:White SolidPeso molecular:754.155Mildronate
CAS:Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitineFórmula:C6H14N2O2Pureza:99.94%Cor e Forma:White SolidPeso molecular:146.1876TETRAHYDROPIPERINE
CAS:Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.Fórmula:C17H23NO3Pureza:98.04% - 99.61%Cor e Forma:SolidPeso molecular:289.3694Guanoclor
CAS:Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.Fórmula:C9H12Cl2N4OPureza:98.79%Cor e Forma:SolidPeso molecular:263.124Telotristat
CAS:Telotristat, active metabolite of LX1606, is an oral tryptophan hydroxylase inhibitor with potential antiserotonergic effects.Fórmula:C25H22ClF3N6O3Pureza:99.70%Cor e Forma:SolidPeso molecular:546.929Fenclonine hydrochloride
CAS:Fenclonine hydrochloride is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.Fórmula:C9H11Cl2NO2Cor e Forma:SolidPeso molecular:236.095
