Hidroxilase
As hidroxilases são uma classe de enzimas que catalisam a hidroxilação de substratos, frequentemente adicionando grupos hidroxila (-OH) a posições específicas dentro das moléculas. Estas enzimas estão envolvidas em uma ampla variedade de vias bioquímicas, incluindo a síntese de hormônios, processos de desintoxicação e o metabolismo de drogas. Inibidores e ativadores de hidroxilases são ferramentas valiosas na pesquisa sobre distúrbios metabólicos, metabolismo de drogas e regulação hormonal. Na CymitQuimica, oferecemos uma seleção de reagentes de hidroxilases de alta qualidade para apoiar sua pesquisa em bioquímica, farmacologia e regulação metabólica.
Foram encontrados 36 produtos de "Hidroxilase"
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Fenclonine
CAS:Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.Fórmula:C9H10ClNO2Pureza:98.81% - >99.99%Cor e Forma:Crystals From Methanol White SolidPeso molecular:199.63ACT-678689
CAS:ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].Fórmula:C23H22ClFN6O4S2Pureza:99.46%Cor e Forma:SolidPeso molecular:565.04Ref: TM-T14119
1mg113,00€5mg259,00€10mg393,00€25mg655,00€50mg905,00€100mg1.216,00€200mg1.634,00€1mL*10mM (DMSO)324,00€Telotristat ethyl
CAS:Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.Fórmula:C27H26ClF3N6O3Pureza:98% - 99.89%Cor e Forma:White SolidPeso molecular:574.98p-Ethynylphenylalanine hydrochloride
CAS:p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1].Fórmula:C11H12ClNO2Pureza:99.03%Cor e Forma:SolidPeso molecular:225.67Butobendine
CAS:Butobendine is a compound derived from gallic acid and exhibits significant antiarrhythmic activity.Fórmula:C32H48N2O10Cor e Forma:SolidPeso molecular:620.73IOX2-NH2-1
CAS:IOX2-NH2-1 inhibits E. coli EGLN-3 (prolyl hydroxylase) with an IC50 of 0.02–1 μM.
Fórmula:C19H17N3O5Pureza:98.77% - 99.91%Cor e Forma:SoildPeso molecular:367.36TPH1-IN-1
TPH1-IN-1 (compound 40) is a xanthine derivative that serves as an inhibitor of tryptophan hydroxylase TPH1, with an IC50 of 110.1 nM.Fórmula:C21H18N6O4SCor e Forma:SolidPeso molecular:450.47TPT-004
TPT-004, a TPH inhibitor, exhibits superior pharmacokinetic and pharmacodynamic properties, and demonstrates efficacy in preclinical models for attenuatingCor e Forma:Odour SolidGSK180
CAS:GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.Fórmula:C10H7Cl2NO4Cor e Forma:SolidPeso molecular:276.07Cuprizone
CAS:Cuprizone is a copper chelator.Cuprizone is used to induce schizophrenia in mice.Cuprizone induces oligodendrocyte death and induces a demyelination response.Fórmula:C14H22N4O2Pureza:≥98%Cor e Forma:SolidPeso molecular:278.35FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Fórmula:C12H9ClN2O4Pureza:97.1% - >99.99%Cor e Forma:SolidPeso molecular:280.66Ro 61-8048
CAS:Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.Fórmula:C17H15N3O6S2Pureza:98% - >99.99%Cor e Forma:SolidPeso molecular:421.45Ref: TM-T1896
2mg37,00€5mg54,00€10mg73,00€25mg114,00€50mg178,00€100mg284,00€200mg512,00€500mg822,00€1mL*10mM (DMSO)60,00€Telotristat
CAS:Telotristat, active metabolite of LX1606, is an oral tryptophan hydroxylase inhibitor with potential antiserotonergic effects.Fórmula:C25H22ClF3N6O3Pureza:99.70%Cor e Forma:SolidPeso molecular:546.93Ref: TM-T21506
5mg46,00€10mg62,00€25mg119,00€50mg187,00€100mg304,00€200mg424,00€1mL*10mM (DMSO)52,00€p-Fluoro-L-phenylalanine
CAS:p-Fluoro-L-phenylalanine: TH substrate, studies enzyme regulation, binds E. coli L-leucine receptor, KD 0.26μM.Fórmula:C9H10FNO2Pureza:99.63%Cor e Forma:White To Off-White PowderPeso molecular:183.18Fenclonine hydrochloride
CAS:Fenclonine hydrochloride is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.Fórmula:C9H11Cl2NO2Cor e Forma:SolidPeso molecular:236.095Telotristat Etiprate
CAS:Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.Fórmula:C27H26ClF3N6O3·C9H9NO3Pureza:99.21% - 99.83%Cor e Forma:White SolidPeso molecular:754.15Ref: TM-T6044
2mg46,00€5mg66,00€10mg92,00€25mg150,00€50mg183,00€100mg325,00€500mg780,00€1mL*10mM (DMSO)85,00€Tetrahydropapaverine hydrochloride
CAS:Tetrahydropapaverine hydrochloride (Norlaudanosine HCl) , an analogue of salsolinol and tetrahydropapaveroline, has neurotoxicity on dopamine neurons.Fórmula:C20H26ClNO4Pureza:99.08%Cor e Forma:White Crystal PowderPeso molecular:379.878Mildronate
CAS:Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitineFórmula:C6H14N2O2Pureza:99.94%Cor e Forma:White Crystalline PowderPeso molecular:146.19TETRAHYDROPIPERINE
CAS:Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.Fórmula:C17H23NO3Pureza:98.04% - 99.61%Cor e Forma:Off-White Low Melting Solid With Characteristic OdourPeso molecular:289.37Nepicastat
CAS:Nepicastat (SYN117) is a potent, BBB-permeable, selective DBH inhibitor with IC50s of 8.5/9 nM in bovine/human.Fórmula:C14H15F2N3SCor e Forma:SolidPeso molecular:295.35Guanoclor
CAS:Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes.
Fórmula:C9H12Cl2N4OPureza:98.79%Cor e Forma:SolidPeso molecular:263.12Nepicastat hydrochloride
CAS:Nepicastat hydrochloride (RS-25560-197 hydrochloride) is a selective, orally active, dopamine-beta-hydroxylase inhibitor that crosses the blood-brain barrier.Fórmula:C14H15F2N3S·HClPureza:98.35% - 99.74%Cor e Forma:SolidPeso molecular:331.81LP-533401
CAS:LP-533401 is an inhibitor of Tryptophan hydroxylase 1. It is used for regulates serotonin production in the gut.Fórmula:C27H22F4N4O3Pureza:98%Cor e Forma:SolidPeso molecular:526.48Phenylthiazolylthiourea
CAS:Phenylthiazolylthiourea ia a dopamine-beta-hydroxylase inhibitor.Fórmula:C10H9N3S2Cor e Forma:SolidPeso molecular:235.33Telotristat besilate
CAS:Telotristat besilate is an inhibitor of tryptophan hydroxylase.Fórmula:C31H28ClF3N6O6SPureza:98%Cor e Forma:SolidPeso molecular:705.11(R)-Nepicastat HCl
CAS:(R)-Nepicastat HCl (RS-25560-198 HCl), R-enantiomer, inhibits bovine/human dopamine-β-hydroxylase (IC50: 25.1/18.3 nM); not affecting other enzymes/receptors.Fórmula:C14H15F2N3S·HClPureza:98%Cor e Forma:SolidPeso molecular:331.81Fenprinast
CAS:Fenprinast is a tryptophan-like bronchodilator utilized in the study of allergic and exercise-induced asthma. It exhibits oral activity.Fórmula:C16H16ClN5OCor e Forma:SolidPeso molecular:329.783-Allylphenol
CAS:3-Allylphenol is an inhibitor of dopamine β-hydroxylase (DBH; Ki = 12 mM).Fórmula:C9H10OCor e Forma:SolidPeso molecular:134.18JM6
CAS:JM6 is a weak kynurenine 3-monooxygenase (KMO) inhibitor that acts on mouse KMO (IC50: 19.85 μM). JM6 can be used to study Alzheimer's disease.Fórmula:C23H26N4O6S2Cor e Forma:SolidPeso molecular:518.61SU 10603
CAS:SU 10603 is a specific inhibitor of 17α-hydroxylase (also known as CYP17A1 and P450c17) used to study steroid hormone synthesis.Fórmula:C15H12ClNOPureza:99.93% - 99.96%Cor e Forma:SolidPeso molecular:257.72EWP 815
CAS:EWP 815, a disulfiram analog, inhibits Ins(1,4)P2, Ins(1,4,5)P3 phosphatases, and dopamine β-hydroxylase.Fórmula:C12H22N4S4Pureza:98%Cor e Forma:SolidPeso molecular:350.59Bupicomide
CAS:Bupicomide is a dopamine β-hydroxylase inhibitor with antihypertensive and vasodilatory activity and may be used in the study of hypertension.Fórmula:C10H14N2OPureza:99.84% - >99.99%Cor e Forma:SolidPeso molecular:178.23LX-1031
CAS:LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.Fórmula:C28H25F3N4O4Pureza:97.123% - 98.97%Cor e Forma:SolidPeso molecular:538.52Ref: TM-T15796
1mg55,00€5mg120,00€10mg187,00€25mg376,00€50mg597,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)143,00€Diethyl-pythiDC
CAS:Diethyl-pythiDC is an collagen prolyl 4-hydroxylase inhibitor.Fórmula:C14H14N2O4SPureza:99.98%Cor e Forma:SolidPeso molecular:306.34p-Ethynylphenylalanine
CAS:p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a tryptophan hydroxylase (TPH) inhibitor, is competitive, effective, selective, and reversible, with a Ki ofFórmula:C11H11NO2Pureza:99.44%Cor e Forma:SolidPeso molecular:189.21GSK 366
CAS:GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).Fórmula:C17H16ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:361.78
