NF-κB

DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed …

Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.

Emlenoflast sodium (MCC7840 sodium), a sulfonylurea, is a selective NLRP3 inflammasome inhibitor with an IC50 …

Emlenoflast (MCC7840) is a selective inhibitor of NLRP3 inflammasome.

NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and …

IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties …

RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting …

IMD-catechol is an innovative dimer compound combining an imidazoquinolinone structure with NF-κB immunomodulatory activity, which …

Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) …

SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant …

Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ.

Biricodar dicitrate (VX-710) is a potent MDR inhibitor with no anticancer activity and can be …

TBK1-IN-1 is a specific and potent TANK-binding kinase 1 (TBK1) inhibitor (IC50: 22.4 nM) with …

IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.

IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.

RIPK2-IN-3 (FCG806791773) is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with an IC50 value of …

IMD-biphenylC is a novel imidazoquinolinone dimer functioning as an NF-κB immunomodulator. It effectively inhibits tumor …

Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside …

IRAK4-IN-28 (compound 42), an orally-active IRAK4 inhibitor (IC50=8.9 nM), exhibits strong binding affinity with a …

IKK-IN-1 is an inhibitor of IKK.

RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 …

WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents …

(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.

BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.

Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays …

TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).

Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK …