NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 389 produtos de "NF-κB"
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MHY884
CAS:MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.Fórmula:C15H14ClNO3SPureza:98%Cor e Forma:SolidPeso molecular:323.79NF-κB-IN-11
CAS:NF-κB-IN-11 (Compound 3i) is an inhibitor of NF-κB, effectively blocking TNF-α-induced NF-κB pathway activation and the nuclear translocation of NF-κB.Fórmula:C19H18O5Pureza:98%Cor e Forma:SolidPeso molecular:326.34APC-0576
CAS:APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.Fórmula:C23H27N3O3Cor e Forma:SolidPeso molecular:393.48Xanthine oxidase-IN-6
Xanthine oxidase-IN-6: potent oral mixed-type XOD inhibitor, IC50 1.37 µM, anti-hyperuricemia, renal protection.Fórmula:C29H34N2O15Cor e Forma:SolidPeso molecular:650.58IMD-biphenylB
CAS:IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.Fórmula:C35H33N5O3Pureza:98%Cor e Forma:SolidPeso molecular:571.67Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Fórmula:C23H17N3OS3Pureza:98.02% - 98.04%Cor e Forma:SolidPeso molecular:447.6IKKβ-IN-1
CAS:IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).Fórmula:C31H30N4O4SCor e Forma:SolidPeso molecular:554.66Bay 65-1942 hydrochloride
CAS:Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.Fórmula:C22H26ClN3O4Cor e Forma:SolidPeso molecular:431.91TRAF-STOP inhibitor 6877002
CAS:TRAF-STOP 6877002 inhibits CD40-TRAF6, curbing leukocyte recruitment and macrophage activation/proliferation in plaques.Fórmula:C17H17NOPureza:99.76%Cor e Forma:SolidPeso molecular:251.32Avenanthramide-C methyl ester
CAS:Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).Fórmula:C17H15NO6Cor e Forma:SolidPeso molecular:329.3Edasalonexent
CAS:Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.Fórmula:C31H42N2O3Pureza:99.13% - >99.99%Cor e Forma:SolidPeso molecular:490.68Ref: TM-T15198
1mg94,00€2mg137,00€5mg222,00€10mg356,00€25mg640,00€50mg1.009,00€1mL*10mM (DMSO)240,00€IMD-ferulic
IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.Fórmula:C36H41N7O4Cor e Forma:SolidPeso molecular:635.76Ro 106-9920
CAS:Inhibitor of NF-κB activationFórmula:C10H7N5OSPureza:98%Cor e Forma:SolidPeso molecular:245.26NF-κB/PON1-IN-1
CAS:NF-κB/PON1-IN-1 (Compound 16) is an NF-κB/PON1 pathway inhibitor with antioxidant activity (IC50: 45.76 μM) and hepatoprotective activity.Fórmula:C20H16N6O4S2Cor e Forma:SolidPeso molecular:468.51BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Fórmula:C10H7NO3Pureza:96.48% - 97%Cor e Forma:Yellow Crystalline PowderPeso molecular:189.17IT-901
CAS:IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.Fórmula:C17H14N2O4SPureza:98.06%Cor e Forma:SolidPeso molecular:342.37NF-κB-IN-3
CAS:NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.Fórmula:C24H18ClF3N2O2Cor e Forma:SolidPeso molecular:458.86DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Fórmula:C13H11NO5Pureza:98%Cor e Forma:SolidPeso molecular:261.23NF-κB-IN-2
CAS:NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.Fórmula:C15H18O3Cor e Forma:SolidPeso molecular:246.3HE 3286
CAS:Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis.Fórmula:C21H30O3Cor e Forma:SolidPeso molecular:330.46
