NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 445 produtos de "NF-κB"
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Neferine
CAS:<p>Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.</p>Fórmula:C38H44N2O6Pureza:98.81% - 99.65%Cor e Forma:SolidPeso molecular:624.77Gossypin
CAS:<p>Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.</p>Fórmula:C21H20O13Pureza:97.57% - 98.97%Cor e Forma:SolidPeso molecular:480.38Aconine
CAS:<p>1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.</p>Fórmula:C25H41NO9Pureza:99.61% - 99.93%Cor e Forma:SolidPeso molecular:499.59Madecassic acid
CAS:<p>Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.</p>Fórmula:C30H48O6Pureza:98.80% - 99.69%Cor e Forma:SolidPeso molecular:504.7Delanzomib
CAS:<p>Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.</p>Fórmula:C21H28BN3O5Pureza:95.52% - 99.46%Cor e Forma:SolidPeso molecular:413.28Deoxyelephantopin
CAS:<p>Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.</p>Fórmula:C19H20O6Pureza:99.6% - 99.71%Cor e Forma:SolidPeso molecular:344.36JH-X-119-01
CAS:<p>JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.</p>Fórmula:C25H20N6O3Pureza:98.42%Cor e Forma:SolidPeso molecular:452.46Aristolochic acid A
CAS:<p>Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort family of plants.</p>Fórmula:C17H11NO7Pureza:99.85% - 99.97%Cor e Forma:Yellow PowderPeso molecular:341.27Indole-3-carbinol
CAS:<p>Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase</p>Fórmula:C9H9NOPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:147.17GSK-872
CAS:<p>GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.</p>Fórmula:C19H17N3O2S2Pureza:99.87% - 99.94%Cor e Forma:SolidPeso molecular:383.493'-Sialyllactose sodium
CAS:<p>3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.</p>Fórmula:C23H38NNaO19Pureza:>99.99%Cor e Forma:SolidPeso molecular:655.53(S)-(+)-Ibuprofen
CAS:<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Fórmula:C13H18O2Pureza:99.51% - 99.86%Cor e Forma:Colourless Crystalline SolidPeso molecular:206.281,3-Dibenzyl-5-fluorouracil
CAS:<p>1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.</p>Fórmula:C18H15FN2O2Cor e Forma:SolidPeso molecular:310.32Gatralimab
CAS:<p>Gatralimab (anti-CD52 mAb) shows successful lymphocyte depletion & repopulation in Phase 1, supporting its study for relapsing MS.</p>Pureza:95%Cor e Forma:LiquidKamebakaurin
CAS:<p>Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.</p>Fórmula:C20H30O5Pureza:98.05%Cor e Forma:SolidPeso molecular:350.45E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Cor e Forma:SolidPeso molecular:378.46BAY32-5915
CAS:<p>BAY32-5915 is a selective inhibitor of IKKalpha.</p>Fórmula:C10H7NO3Pureza:96.48% - 97%Cor e Forma:Yellow Crystalline PowderPeso molecular:189.17IMD-biphenylB
CAS:<p>IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.</p>Fórmula:C35H33N5O3Pureza:98%Cor e Forma:SolidPeso molecular:571.67SZM679
<p>SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.</p>Fórmula:C27H18F5N3O5SPureza:98%Cor e Forma:SolidPeso molecular:591.51NF-κB-IN-3
CAS:<p>NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.</p>Fórmula:C24H18ClF3N2O2Cor e Forma:SolidPeso molecular:458.86
