NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 389 produtos de "NF-κB"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
XT2
CAS:XT2 is a potent, oral NF-κB-inducing kinase (NIK) inhibitor with an IC50 of 9.1 nM, reduces ALT levels, and curbs immune cell liver infiltration.Fórmula:C19H14FN5OSCor e Forma:SolidPeso molecular:379.41CID-2858522
CAS:CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).Fórmula:C28H39N3O3Pureza:96.12%Cor e Forma:SolidPeso molecular:465.63DMX-129
CAS:DMX-129 is a chemical compound acting as an inhibitor for both ΙΚΚε and TBK-1, demonstrating efficacy with IC50 values of below 30 nM for each [1].Fórmula:C19H17FN8Cor e Forma:SolidPeso molecular:376.39TBK1/IKKε-IN-4
CAS:TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nMFórmula:C28H35N7O4Cor e Forma:SolidPeso molecular:533.62HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Fórmula:C19H16ClN3O3SPureza:98.07% - 98.17%Cor e Forma:SolidPeso molecular:401.87Ref: TM-T11573
2mg137,00€5mg222,00€10mg356,00€25mg708,00€50mg1.063,00€100mg1.603,00€200mg2.187,00€1mL*10mM (DMSO)245,00€TNF-α-IN-18
CAS:TNF-α-IN-18 is a small molecule TNF-α inhibitor that blocks NF-κB translocation, alleviates sepsis in models, and protects against rheumatoid arthritis in mice.Fórmula:C16H7ClF2O4Pureza:99.77%Cor e Forma:SolidPeso molecular:336.67Anti-inflammatory agent 21
CAS:Compound 9o: orally active, low-toxicity anti-inflammatory; inhibits NO (IC50: 0.76 μM), blocks NF-κB/MAPK, reduces arthritis symptoms.Fórmula:C24H21FO6Cor e Forma:SolidPeso molecular:424.42Sul-121 HCl
CAS:Sul-121 HCl combats COPD by reducing inflammation and AHR via oxidative stress inhibition.Fórmula:C18H27ClN2O3Pureza:98%Cor e Forma:SolidPeso molecular:354.87Asperbisabolane L
Asperbisabolane L, a sesquiterpenoid, combats inflammation by blocking NF-κB signaling and NO in BV-2 cells.Fórmula:C12H14O3Cor e Forma:SolidPeso molecular:206.24HSR1304
CAS:HSR1304 (5d) inhibits NFκB, key in diseases like cancer, offering research potential.Fórmula:C24H21ClN2O3Cor e Forma:SolidPeso molecular:420.89GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Fórmula:C22H19N3O5S2Pureza:98.42%Cor e Forma:SolidPeso molecular:469.53PHA-408
CAS:PHA-408 is a novel potent, highly selective and ATP-competitive inhibitor of IKB kinase-2.Fórmula:C29H27ClFN7O2Pureza:98%Cor e Forma:SolidPeso molecular:560.021-Dehydro-[10]-gingerdione
CAS:1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.Fórmula:C21H30O4Cor e Forma:SolidPeso molecular:346.46IMD-catechol
CAS:IMD-catechol: an imidazoquinolinone-based dimer with NF-κB activity; improves CT26 cancer treatment, low toxicity.Fórmula:C31H34N6O3Pureza:98%Cor e Forma:SolidPeso molecular:538.64NF-κB-IN-8
CAS:NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2.Fórmula:C24H21N3O3Pureza:98%Cor e Forma:SolidPeso molecular:399.44CAY10575
CAS:CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.Fórmula:C22H21N3O6S2Cor e Forma:SolidPeso molecular:487.55IMD-biphenylA
CAS:IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFórmula:C35H33N5O2Pureza:98%Cor e Forma:SolidPeso molecular:555.67RIPK1-IN-9
CAS:RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Fórmula:C26H25FN6O2Pureza:99.74%Cor e Forma:SolidPeso molecular:472.51Ref: TM-T63055
1mg148,00€5mg344,00€10mg474,00€25mg705,00€50mg944,00€100mg1.283,00€200mg1.710,00€1mL*10mM (DMSO)399,00€Zharp2-1
CAS:Zharp2-1 is a RIPK2 inhibitor that alleviates MDP-induced peritonitis symptoms in mice and can be used to study inflammatory bowel disease (IBD).
Fórmula:C19H18N3O2PSPureza:99.41%Cor e Forma:SolidPeso molecular:383.4SP-100030
CAS:SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.Fórmula:C14H5ClF9N3OPureza:99.79%Cor e Forma:SolidPeso molecular:437.65Ref: TM-T24816
1mg34,00€5mg70,00€10mg99,00€25mg230,00€50mg358,00€100mg513,00€500mgA consultar1mL*10mM (DMSO)78,00€
![1-Dehydro-[10]-gingerdione](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT72208.webp&w=3840&q=75)
