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NF-κB

NF-κB

O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.

Foram encontrados 445 produtos de "NF-κB"

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  • 1-Dehydro-[10]-gingerdione
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    1-Dehydro-[10]-gingerdione

    CAS:
    <p>1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.</p>
    Fórmula:C21H30O4
    Cor e Forma:Solid
    Peso molecular:346.46

    Ref: TM-T72208

  • ABD-350
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    ABD-350

    CAS:
    <p>ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.</p>
    Fórmula:C19H22F2O2
    Cor e Forma:Solid
    Peso molecular:320.37

    Ref: TM-T26513

  • MHY884
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    MHY884

    CAS:
    <p>MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.</p>
    Fórmula:C15H14ClNO3S
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:323.79

    Ref: TM-T25807

  • IT-901
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    IT-901

    CAS:
    <p>IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.</p>
    Fórmula:C17H14N2O4S
    Pureza:98.06%
    Cor e Forma:Solid
    Peso molecular:342.37

    Ref: TM-T15601

  • IKK2-IN-4
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    IKK2-IN-4

    CAS:
    <p>IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.</p>
    Fórmula:C12H11N3O2S
    Pureza:>99.99%
    Cor e Forma:Solid
    Peso molecular:261.3

    Ref: TM-T36524

  • CID-2858522
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    CID-2858522

    CAS:
    <p>CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).</p>
    Fórmula:C28H39N3O3
    Pureza:96.12%
    Cor e Forma:Solid
    Peso molecular:465.63

    Ref: TM-TQ0305

  • DHMEQ racemate
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    DHMEQ racemate

    CAS:
    <p>DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.</p>
    Fórmula:C13H11NO5
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:261.23

    Ref: TM-T11018

  • AP-1/NF-κB activation inhibitor 1
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    AP-1/NF-κB activation inhibitor 1

    CAS:
    <p>AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal</p>
    Fórmula:C13H11F3N4O4
    Pureza:99.52% - 99.91%
    Cor e Forma:Solid
    Peso molecular:344.25

    Ref: TM-T9656

  • APC-0576
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    APC-0576

    CAS:
    <p>APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.</p>
    Fórmula:C23H27N3O3
    Cor e Forma:Solid
    Peso molecular:393.48

    Ref: TM-T69453

  • Avenanthramide-C methyl ester
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    Avenanthramide-C methyl ester

    CAS:
    <p>Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).</p>
    Fórmula:C17H15NO6
    Cor e Forma:Solid
    Peso molecular:329.3

    Ref: TM-T36198

  • Edasalonexent
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    Edasalonexent

    CAS:
    <p>Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor for the improvement of Duchenne muscular dystrophy.</p>
    Fórmula:C31H42N2O3
    Pureza:99.13% - >99.99%
    Cor e Forma:Solid
    Peso molecular:490.68

    Ref: TM-T15198

  • IMD-ferulic
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    IMD-ferulic

    <p>IMD-ferulic, a compound that forms covalent bonds, acts as an NF-κB modulator, enhancing the adjuvanticity of small molecule immune potentiators.</p>
    Fórmula:C36H41N7O4
    Cor e Forma:Solid
    Peso molecular:635.76

    Ref: TM-T72986

  • Ro 106-9920
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    Ro 106-9920

    CAS:
    <p>Inhibitor of NF-κB activation</p>
    Fórmula:C10H7N5OS
    Pureza:98%
    Cor e Forma:Solid
    Peso molecular:245.26

    Ref: TM-T23242

  • Bay 65-1942 hydrochloride
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    Bay 65-1942 hydrochloride

    CAS:
    <p>Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ.</p>
    Fórmula:C22H26ClN3O4
    Cor e Forma:Solid
    Peso molecular:431.91

    Ref: TM-T14508

  • HPN-01
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    HPN-01

    CAS:
    <p>HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.</p>
    Fórmula:C19H16ClN3O3S
    Pureza:98.07% - 98.17%
    Cor e Forma:Solid
    Peso molecular:401.87

    Ref: TM-T11573

  • RIP2 Kinase Inhibitor 3
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    RIP2 Kinase Inhibitor 3

    CAS:
    <p>RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.</p>
    Fórmula:C19H24N4O3S
    Pureza:99.32% - 99.52%
    Cor e Forma:Solid
    Peso molecular:388.48

    Ref: TM-T12728

  • NF-κB-IN-2
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    NF-κB-IN-2

    CAS:
    <p>NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells.</p>
    Fórmula:C15H18O3
    Cor e Forma:Solid
    Peso molecular:246.3

    Ref: TM-T60357

  • Gue1654
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    Gue1654

    CAS:
    <p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>
    Fórmula:C23H17N3OS3
    Pureza:98.02% - 98.04%
    Cor e Forma:Solid
    Peso molecular:447.6

    Ref: TM-T27502

  • GSK319347A
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    GSK319347A

    CAS:
    <p>GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.</p>
    Fórmula:C22H19N3O5S2
    Pureza:98.42%
    Cor e Forma:Solid
    Peso molecular:469.53

    Ref: TM-T15558

  • IKKβ-IN-1
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    IKKβ-IN-1

    CAS:
    <p>IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM).</p>
    Fórmula:C31H30N4O4S
    Cor e Forma:Solid
    Peso molecular:554.66

    Ref: TM-T63919