NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 389 produtos de "NF-κB"
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NFATc1-IN-1
CAS:NFATc1-IN-1 (A04) inhibits RANKL-induced osteoclast formation with 1.57 μM IC50, blocking NFATc1 translocation.Fórmula:C13H8F2INO2Pureza:99.98%Cor e Forma:SolidPeso molecular:375.11B022
CAS:B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Fórmula:C19H16ClN5OSPureza:99.74%Cor e Forma:SolidPeso molecular:397.88IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Fórmula:C22H25F3N4O3Pureza:98.09%Cor e Forma:SolidPeso molecular:450.45Zabedosertib
CAS:Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential.
Fórmula:C20H21F3N4O4SPureza:98.54%Cor e Forma:SolidPeso molecular:470.47PF-184
PF-184: potent IKK-2 inhibitor, selective over 30+ kinases; useful for asthma & COPD research. IC50: 37 nM.Fórmula:C32H32ClFN6O4Cor e Forma:SolidPeso molecular:619.09CGA-JK3
CAS:CGA-JK3 is an IkappaB kinase inhibitor in innate immune process.Fórmula:C15H19NO3Pureza:98%Cor e Forma:SolidPeso molecular:261.32TBK1-IN-1
CAS:TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Fórmula:C27H37N7O2Pureza:99.81% - >99.99%Cor e Forma:SolidPeso molecular:491.63IMD-biphenylC
CAS:IMD-biphenylC: New, dual-action imidazoquinolinone dimer; inhibits tumor growth, low inflammation/toxicity.Fórmula:C35H33N5O3Pureza:98%Cor e Forma:SolidPeso molecular:571.67Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:98.46% - 99.13%Cor e Forma:SolidPeso molecular:767.00Glabrescone C
CAS:Glabrescone C exhibits strong anti-inflammatory properties through direct binding to IKKα/β.
Fórmula:C19H22O7Cor e Forma:SolidPeso molecular:362.37ACHP Hydrochloride
CAS:ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.Fórmula:C21H25ClN4O2Pureza:99.83%Cor e Forma:SolidPeso molecular:400.9Ref: TM-T10237
1mg66,00€5mg144,00€10mg227,00€25mg375,00€50mg540,00€100mg777,00€500mg1.549,00€1mL*10mM (DMSO)159,00€(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Fórmula:C27H30F3N9OPureza:98%Cor e Forma:SolidPeso molecular:553.58IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Fórmula:C22H26ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:431.91PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Fórmula:C22H24N4O3SPureza:98.09% - 99.64%Cor e Forma:SolidPeso molecular:424.52Ref: TM-T12493
1mg81,00€5mg170,00€10mg274,00€25mg518,00€50mg747,00€100mg938,00€1mL*10mM (DMSO)188,00€IR-Crizotinib
CAS:IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranialFórmula:C53H57Cl2FIN7OPureza:98%Cor e Forma:SolidPeso molecular:1024.88NF-κB-IN-13
CAS:NF-κB-IN-13 (compound 12) markedly suppresses LPS-induced NF-κB activation and NO synthesis in RAW264.7 macrophages, exhibiting anti-inflammatory properties [1Fórmula:C20H20O5Pureza:98%Cor e Forma:SolidPeso molecular:340.37Dimethoxycurcumin
CAS:Dimethoxycurcumin is a stable curcumin analog causing epigenetic shifts in leukemia cells, affecting gene expression.Fórmula:C23H24O6Pureza:99.87%Cor e Forma:SolidPeso molecular:396.43Ref: TM-T19853
5mg52,00€10mg77,00€25mg133,00€50mg225,00€100mg330,00€200mg470,00€1mL*10mM (DMSO)52,00€Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.46GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Fórmula:C28H30N4O3Pureza:98.24%Cor e Forma:SolidPeso molecular:470.56
