NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 445 produtos de "NF-κB"
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IRAK4-IN-10
CAS:<p>IRAK4-IN-10, a potent IRAK4 blocker with IC50 of 1.5 nM, may treat inflammation, autoimmunity, and cancer.</p>Fórmula:C22H24N8Pureza:98.55%Cor e Forma:SolidPeso molecular:400.48Hesperidin methylchalcone
CAS:<p>Hesperidin methylchalcone, from Citrus, is a potent antioxidant that inhibits NF-κB to alleviate gout arthritis in mice.</p>Fórmula:C29H36O15Pureza:99.53%Cor e Forma:Yellow PowderPeso molecular:624.59IRAK inhibitor 2
CAS:<p>IRAK inhibitor 2 (IRAK-IN-2) is a potent inhibitor of interleukin 1 receptor-associated kinase 4 (IRAK-4) for the study of inflammation-related diseases.</p>Fórmula:C17H14N4O2Pureza:97.90% - 99.58%Cor e Forma:SolidPeso molecular:306.32RS 09
CAS:<p>TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.</p>Fórmula:C31H49N9O9Pureza:98%Cor e Forma:SolidPeso molecular:691.78Edecesertib
CAS:<p>Edecesertib (GS 5718) is an IRAK-4 inhibitor with anti-inflammatory activity for the study of rheumatoid arthritis.</p>Fórmula:C22H22FN7O2Pureza:98.84% - 99.94%Cor e Forma:SolidPeso molecular:435.45BIZ 114
CAS:<p>BIZ 114 potently inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and/or treat ophthalmic disorders.</p>Fórmula:C24H40O3Cor e Forma:SolidPeso molecular:376.57DTP3
CAS:<p>DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.</p>Fórmula:C26H35N7O5Cor e Forma:SolidPeso molecular:525.6TOMATIDINE HYDROCHLORIDE
CAS:<p>Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.</p>Fórmula:C27H46ClNO2Pureza:99.75% - ≥95%Cor e Forma:SolidPeso molecular:452.11QNZ
CAS:<p>QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.</p>Fórmula:C22H20N4OPureza:99.17% - 99.18%Cor e Forma:White SolidPeso molecular:356.42BEC hydrochloride
CAS:<p>BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.</p>Fórmula:C5H12BNO4S·ClHPureza:98.65% - 99.28%Cor e Forma:SolidPeso molecular:229.49CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Fórmula:C20H28O3Pureza:97.06% - 99.08%Cor e Forma:SolidPeso molecular:316.43Demethyleneberberine
CAS:<p>Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either</p>Fórmula:C19H18NO4Pureza:98.08% - 99.18%Cor e Forma:SolidPeso molecular:324.35Morusin
CAS:<p>Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.</p>Fórmula:C25H24O6Pureza:98.68% - 99.8%Cor e Forma:SolidPeso molecular:420.45EUK-134
CAS:<p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>Fórmula:C18H18ClMnN2O4Pureza:98.39%Cor e Forma:SolidPeso molecular:416.74Flavanomarein
CAS:<p>Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.</p>Fórmula:C21H22O11Pureza:98.63% - 99.54%Cor e Forma:SolidPeso molecular:450.39Berbamine
CAS:<p>Berbamine is a natural product extracted from Phellodendron amurense.</p>Fórmula:C37H40N2O6Pureza:98.92% - 99.67%Cor e Forma:White Crystal PowderPeso molecular:608.723'-Sialyllactose
CAS:<p>3'-Sialyllactose (3'-SL), a prebiotic, supports immunity, reduces inflammation and arthritis, and is low-toxicity for research.</p>Fórmula:C23H39NO19Cor e Forma:SolidPeso molecular:633.55OPHIOPOGONIN D
CAS:<p>Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.</p>Fórmula:C44H70O16Pureza:99.46% - ≥95%Cor e Forma:SolidPeso molecular:855.02BI-69A11
CAS:<p>BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.</p>Fórmula:C25H16ClN3O2Pureza:96.97%Cor e Forma:SolidPeso molecular:425.87Sulindac sodium
CAS:<p>Sulindac (sodium) (MK-231) is an NSAID used for arthritis pain, swelling, gout, and as an immunomodulator in CRC therapy.</p>Fórmula:C20H16FNaO3SCor e Forma:SolidPeso molecular:378.39
