NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Foram encontrados 445 produtos de "NF-κB"
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Vamorolone
CAS:<p>Vamorolone (VBP15) is a steroid-like drug that treats muscular dystrophy with fewer side effects and inhibits NF-κB.</p>Fórmula:C22H28O4Pureza:99.54%Cor e Forma:SolidPeso molecular:356.46Robinin
CAS:<p>Robinin: a kaempferol-derived flavone glycoside with antibacterial, diuretic traits; minimal effect on Colo 320 MDR1/LRP resistance; detected in MCF-7 cells.</p>Fórmula:C33H40O19Pureza:98.78% - 99.13%Cor e Forma:SolidPeso molecular:740.66Polygalasaponin F
CAS:<p>Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.</p>Fórmula:C53H86O23Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:1091.24Embelin
CAS:<p>Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).</p>Fórmula:C17H26O4Pureza:97.07% - 99.88%Cor e Forma:SolidPeso molecular:294.39Triptolide
CAS:<p>Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.</p>Fórmula:C20H24O6Pureza:97.19% - 99.97%Cor e Forma:White To Off-White SolidPeso molecular:360.4Barlerin
CAS:<p>Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and protective effect on oxygen-glucose deprivation-induced injury</p>Fórmula:C19H28O12Pureza:99.83% - ≥95%Cor e Forma:SolidPeso molecular:448.42TBK1/IKKε-IN-5
CAS:<p>TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).</p>Fórmula:C28H31N7O3Pureza:98.77%Cor e Forma:SolidPeso molecular:513.59Mollugin
CAS:<p>Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.</p>Fórmula:C17H16O4Pureza:99.87% - ≥95%Cor e Forma:SolidPeso molecular:284.31Tyrosol
CAS:<p>Tyrosol (2-(4-Hydroxyphenyl)ethanol) is a phenolic antioxidant that is naturally present in several foods such as wines and green tea and is present most</p>Fórmula:C8H10O2Pureza:99.24% - 99.86%Cor e Forma:SolidPeso molecular:138.16PI-1840
CAS:<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Fórmula:C22H26N4O3Pureza:98.82%Cor e Forma:SolidPeso molecular:394.47SM-7368
CAS:<p>The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.</p>Fórmula:C10H5ClN4O5SPureza:99.64%Cor e Forma:SolidPeso molecular:328.69IRAK-1-4 Inhibitor I
CAS:<p>IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.</p>Fórmula:C20H21N5O4Pureza:98% - 99.89%Cor e Forma:SolidPeso molecular:395.41Tomatidine
CAS:<p>Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.</p>Fórmula:C27H45NO2Pureza:99.94% - 99.98%Cor e Forma:SolidPeso molecular:415.6511-Keto-β-boswellic acid
CAS:<p>11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.</p>Fórmula:C30H46O4Pureza:99.68%Cor e Forma:SolidPeso molecular:470.68RIPA-56
CAS:<p>RIPA-56 is an inhibitor of RIP1</p>Fórmula:C13H19NO2Pureza:99.53% - 99.93%Cor e Forma:SolidPeso molecular:221.3Zimlovisertib
CAS:<p>Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4).</p>Fórmula:C18H20FN3O4Pureza:98.21%Cor e Forma:SolidPeso molecular:361.37Malachite green oxalate
CAS:<p>Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.</p>Fórmula:C23H25N2·C2HO4C2H2O4Cor e Forma:Dark Green Crystals With A Metallic LusterPeso molecular:463.51Sarsasapogenin
CAS:<p>Sarsasapogenin (Parigenin) is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.</p>Fórmula:C27H44O3Pureza:90% - 99.73%Cor e Forma:White Or Off-Withe PowderPeso molecular:416.64Obtusifolin
CAS:<p>Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.</p>Fórmula:C16H12O5Pureza:99.78% - 99.99%Cor e Forma:SolidPeso molecular:284.26Neferine
CAS:<p>Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.</p>Fórmula:C38H44N2O6Pureza:98.81% - 99.65%Cor e Forma:SolidPeso molecular:624.77Gossypin
CAS:<p>Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.</p>Fórmula:C21H20O13Pureza:97.57% - 98.97%Cor e Forma:SolidPeso molecular:480.38Aconine
CAS:<p>1. Aconine (Jesaconine) is the febrifuge. 2. Aconine possesses gastric anaesthetic props.</p>Fórmula:C25H41NO9Pureza:99.61% - 99.93%Cor e Forma:SolidPeso molecular:499.59Madecassic acid
CAS:<p>Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.</p>Fórmula:C30H48O6Pureza:98.80% - 99.69%Cor e Forma:SolidPeso molecular:504.7Delanzomib
CAS:<p>Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.</p>Fórmula:C21H28BN3O5Pureza:95.52% - 99.46%Cor e Forma:SolidPeso molecular:413.28Deoxyelephantopin
CAS:<p>Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.</p>Fórmula:C19H20O6Pureza:99.6% - 99.71%Cor e Forma:SolidPeso molecular:344.36JH-X-119-01
CAS:<p>JH-X-119-01 is a highly potent and selective covalent inhibitor of IRAK-1.</p>Fórmula:C25H20N6O3Pureza:98.42%Cor e Forma:SolidPeso molecular:452.46Aristolochic acid A
CAS:<p>Aristolochic acid A (TR 1736) is a compound of mutagenic, carcinogenic, and nephrotoxic compounds commonly found in the Birthwort family of plants.</p>Fórmula:C17H11NO7Pureza:99.85% - 99.97%Cor e Forma:Yellow PowderPeso molecular:341.27Indole-3-carbinol
CAS:<p>Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase</p>Fórmula:C9H9NOPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:147.17GSK-872
CAS:<p>GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.</p>Fórmula:C19H17N3O2S2Pureza:99.87% - 99.94%Cor e Forma:SolidPeso molecular:383.493'-Sialyllactose sodium
CAS:<p>3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis and can be used to study inflammation.</p>Fórmula:C23H38NNaO19Pureza:>99.99%Cor e Forma:SolidPeso molecular:655.53(S)-(+)-Ibuprofen
CAS:<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Fórmula:C13H18O2Pureza:99.51% - 99.86%Cor e Forma:Colourless Crystalline SolidPeso molecular:206.281,3-Dibenzyl-5-fluorouracil
CAS:<p>1,3-Dibenzyl-5-fluorouracil is a chemical inhibitor that suppresses the formation of osteoclasts, functioning by downregulating the signaling pathways of nuclear factor κB ligand receptor activator (Receptor activator of NF-κB ligand, RANKL) and macrophage colony-stimulating factor (M-CSF). This compound is used in the research of metabolic bone diseases.</p>Fórmula:C18H15FN2O2Cor e Forma:SolidPeso molecular:310.32Gatralimab
CAS:<p>Gatralimab (anti-CD52 mAb) shows successful lymphocyte depletion & repopulation in Phase 1, supporting its study for relapsing MS.</p>Pureza:95%Cor e Forma:LiquidKamebakaurin
CAS:<p>Kamebakaurin combats liver toxicity, cancer, inflammation, and neuroinflammation by blocking NF-κB, HIF-1α, and key signaling pathways.</p>Fórmula:C20H30O5Pureza:98.05%Cor e Forma:SolidPeso molecular:350.45E3330
CAS:<p>E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.</p>Fórmula:C21H30O6Pureza:99.52%Cor e Forma:SolidPeso molecular:378.46BAY32-5915
CAS:<p>BAY32-5915 is a selective inhibitor of IKKalpha.</p>Fórmula:C10H7NO3Pureza:96.48% - 97%Cor e Forma:Yellow Crystalline PowderPeso molecular:189.17IMD-biphenylB
CAS:<p>IMD-biphenylB: Potent NF-κB inhibitor, curbs tumor growth with low inflammation and toxicity.</p>Fórmula:C35H33N5O3Pureza:98%Cor e Forma:SolidPeso molecular:571.67SZM679
<p>SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.</p>Fórmula:C27H18F5N3O5SPureza:98%Cor e Forma:SolidPeso molecular:591.51NF-κB-IN-3
CAS:<p>NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.</p>Fórmula:C24H18ClF3N2O2Cor e Forma:SolidPeso molecular:458.861-Dehydro-[10]-gingerdione
CAS:<p>1-Dehydro-[10]-gingerdione blocks IKKβ, curbs IκBα phosphorylation, halts NF-κB activity, and aids inflammation research.</p>Fórmula:C21H30O4Cor e Forma:SolidPeso molecular:346.46ABD-350
CAS:<p>ABD-350 is ligand-induced inhibitor of nuclear factor kappaB phosphorylation.</p>Fórmula:C19H22F2O2Cor e Forma:SolidPeso molecular:320.37MHY884
CAS:<p>MHY884 inhibits tyrosinase and UVB-triggered NF-κB activation by reducing oxidative stress.</p>Fórmula:C15H14ClNO3SPureza:98%Cor e Forma:SolidPeso molecular:323.79IT-901
CAS:<p>IT-901: Oral NF-κB c-Rel inhibitor, IC50 0.1 µM. Blocks c-Rel/DNA binding, IC50 3 µM. Antitumor naphthalene derivative for lymphoma/myeloma therapy.</p>Fórmula:C17H14N2O4SPureza:98.06%Cor e Forma:SolidPeso molecular:342.37IKK2-IN-4
CAS:<p>IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.</p>Fórmula:C12H11N3O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:261.3CID-2858522
CAS:<p>CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).</p>Fórmula:C28H39N3O3Pureza:96.12%Cor e Forma:SolidPeso molecular:465.63DHMEQ racemate
CAS:<p>DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.</p>Fórmula:C13H11NO5Pureza:98%Cor e Forma:SolidPeso molecular:261.23AP-1/NF-κB activation inhibitor 1
CAS:<p>AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal</p>Fórmula:C13H11F3N4O4Pureza:99.52% - 99.91%Cor e Forma:SolidPeso molecular:344.25APC-0576
CAS:<p>APC-0576, an (S,S)-isomer, blocks NF-kappaB gene activation and may reduce inflammation in human cells.</p>Fórmula:C23H27N3O3Cor e Forma:SolidPeso molecular:393.48Avenanthramide-C methyl ester
CAS:<p>Avenanthramide-C methyl ester blocks IKK/IκB phosphorylation, inhibits NF-κB, and reduces IL-6, IL-8, MCP-1 in endothelial cells (IC50 ~40 μM).</p>Fórmula:C17H15NO6Cor e Forma:SolidPeso molecular:329.3
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